|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 4 | Multimodality therapy for stage Ⅲ non-small-cell lung cancer显示文摘 | Daniel F Nena M Kathy SA | 2005 | J Clin Oncol2005，23，14： | 1 |
| 5 | Incremental effects of serum uric acid levels,autonomic dysfunction,and low-grade inflammation on nocturhal blood pressure in untreated hypertensive patients and normotensive individuals显示文摘 | Erden M Kocaman SA Poyraz F | | 0，，07： | 1 |
| 6 | Intraabdom inal hyperten- sion is anindependent cause of postoperative renalimpairment 显示文摘 | Sugrue M Jones F Deane SA | 1999 | Arch Surg1999，134，： | 1 |
| 7 | IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease显示文摘 | Tremelling M Cummings F Fisher SA | 2007 | Gastroenterology2007，132，5： | 1 |
| 8 | Treatment of infertility in women with polycystic ovary syndrome 显示文摘 | Santana L F Ferriani R A Sa M F | 2008 | Rev Bras Ginecol Obstet2008，30，4： | 1 |
| 9 | GC-ECD evaluation of dicofol toxicity to tropical Astyanax bimaculatus 显示文摘 | LANCAS F M SA O R RISSATO S R | 1996 | Schubarti Chromatographia1996，43，1112： | 1 |
| 10 | Intra-abdominal hypertension is an independent cause of postoperative renal impairment显示文摘 | Sugrue M Jones F Deane SA | 1999 | Arch Surg1999，134，10： | 1 |
| 11 | Incremental effects of serum uric acid levels,autonomic dysfunction,and low-grade inflammation on nocturnal blood pressure in untreated hypertensive patients and normotensive individuals显示文摘 | ERDEN M KOCAMAN SA POYRAZ F | 2011 | Turk Kardiyol Dern Ars2011，39，7： | 1 |
| 12 | Techniques for cryopreservation of individual or small numbers of human spermatozoa:a systematic review显示文摘 | Abdel Hafez F Bedaiwy M El-Nashar SA | 2009 | Hum Reprod Update2009，15，2： | 1 |
| 13 | Mechanism of Action ff a New Component ff the Ca2 + - Dependent Proteolytic System in Rat Brain : The Calpain Avtivator 显示文摘 | Melloni E Michetti M Sa]amino F and Sparatpm B | 1998 | Biochemical and Biophysical Communications1998，，249： | 1 |
| 14 | Acyl - CoA - binding Protein Is a m - calpain Activator 显示文摘 | Melloni E Averna M Sa]amlno F Sparatore B and Minafra R | 2000 | The Journal of Biological Chemistry2000，，275： | 1 |
| 15 | Clinical characteristics and evolution of syphilis in 24 HIV+ individuals in Rio de Janeiro,Brazil显示文摘 | Gutierrez-Galhardo M C do Valle G F Sa F C | 2005 | Rev Inst Med Trop Sao Paulo2005，47，： | 1 |
| 16 | Regulation of angiopoietin and Tie-2 receptor expression in nonreproductive tissues by estrogen显示文摘 | Ye F Florian M Magder SA | 2002 | Steroids2002，67，34： | 1 |
| 17 | Interaction and effect of annealing temperature on primers used in differentially expressed display RT-PCR 显示文摘 | Khusbbeer L Sa F Walter C M | 1998 | Nucleic Acid Res1998，26，3： | 1 |
| 18 | Microglial response to amyloid plaques in APPsw transgenic mice 显示文摘 | Frautschy SA Yang F Irrizarry M -t al | 1998 | Am J Pathol1998，152，1： | 1 |
| 19 | Intra- abdominal hypertension is an independent cause of postoperative renal impairment显示文摘 | Sugrue M Jones F Deane SA | 1999 | Arch Surg1999，134，10： | 1 |
| 20 | Introduction of digestive a-amylase in larvae of Zabrotes subfasciatus (Coleoptera: Bruchidae) in response to ingestion of common bean a-amylase inhibitor 显示文摘 | Silva C P Terra W R de Sa M F G Samuels R I | 2001 | Journal of Insect Physiology2001，47，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员