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| 1 | Therapeutic Effect of Dimethyl Dimethoxy Biphenyl Dicarboxylate on Collagen-Induced Arthritis in Rats显示文摘Objective:To study the effect of oral administration of dimethyl dimethoxy biphenyl dicarboxylate(DDB) on adjusting angiogeneic/inflammatory mediators and ameliorating the pathology of bones in rats with collagen-induced arthritis(CIA).Methods:Wistar rat model of CIA was set up using bovine collagen type Ⅱ.Fifty rats were divided into five groups randomly:normal,CIA model,DDB treatment,methotrexate(MTX) treatment,and combined DDB+MTX treatment.Ankle joints of rats were imaged with digital X-ray machine to show the destruction of joints.Fore and hind paw and knee joints were removed above the ankle joint then processed for haematoxylin and eosin staining.Plasma levels of vascular endothelial growth factor(VEGF),platelet derived growth factor,interleukin-8(IL-8),IL-4,tumor necrosis factor α(TNF-α),and cyclooxygenase-2(COX-2) were quantified by enzyme-linked immunosorbent assay.Nitric oxide levels were detected by Griess reagent.Results:Compared with the CIA model group,a remarkable reduction in various angiogenic(VEGF and IL-8) and inflammatory mediators(TNF-α,IL-4 and COX-2) after treatment with DDB either alone or combined with MTX(P<0.05 or P<0.01).Histopathological and X-ray findings were confirmatory to the observed DDB anti-arthritic effect.The DDB-treated group showed amelioration in signs of arthritis which appeared essentially similar to normal.Conclusion:Our data shed light on the therapeutic efficacy of DDB in experimental rheumatoid arthritis(RA) compared with a choice drug(MTX) and it may be offered as a second-line drug in the treatment of RA. | Roba M Talaat Amira S Abo-EI-Atta Sabah M Farou Karima I EI-Dosoky | 2015 | Chinese Journal of Integrative Medicine2015，21，11： | 1 |
| 2 | Splashing in oxygen steelmaking 显示文摘 | Sabah S Brooks G | 2014 | ISIJ International2014，54，4： | 1 |
| 3 | Enantioseparation of aspartyl dipeptides by CE: Comparison between 18-crown-6-tetracarboxylic acid and carboxymethyl-beta -cyclodextrin as chiralselector显示文摘 | Verleysen K Sabah S Scriba G | 1999 | Chromatographia1999，49，34： | 1 |
| 4 | Jassim image-quality-based adaptive face recognition显示文摘 | Harin S Sabah A | 2010 | IEEE Transactions on Instrumenation and Measurement2010，59，4： | 1 |
| 5 | Flocculation of fine particles in ceramic wastewater using new types of polymeric flocculants显示文摘 | Cengiz I Sabah E Ozgen S | | 0，，3： | 1 |
| 6 | Principal component and multiple regression analysis in modelling of ground-level ozone and factors affecting its concentrations显示文摘 | Abdul-Wahab Sabah A Bakheit Charles S Al-Alawi Saleh M | 2005 | Environmental Modelling & Software2005，20，10： | 1 |
| 7 | Modeling and optimization of hydrocyclone processing oflow grade bentonites 显示文摘 | 6ZGEN S YILDIZ A t AW' KAN A SABAH E | 2009 | Application Clay Sci2009，46，： | 1 |
| 8 | Haploid Plant Production from Pollen Grains of Sturt's Desert Pea via Somatic Embryogenesis 显示文摘 | Sudhersan C Jibi Manuel S Al- Sabah L | 2008 | American-Eurasian Journal of Scientific Research2008，3，1： | 1 |
| 9 | Particle swarm optimization for task assignment problem 显示文摘 | Ayed S Imtiaz S Sabah A M | 2002 | Microprocessors and Microsystems2002，26，： | 1 |
| 10 | Fibrin sealant associated with increased body temperature and leukocytosis after laparoscopic gastric bypass 显示文摘 | Efthimiou E Al -Sabah S Sampalis J S | 2010 | Surg Obes Relat Dis2010，6，1： | 1 |
| 11 | Sepiolite: an effective bleaching adsorbent for the physical refining of degummed rapeseed oil 显示文摘 | SABAH E CELIK M S | 2005 | JAmOilChemSoc2005，82，12： | 1 |
| 12 | Cost - effectiveness of proton- pump inhibition before endoscopy in upper gastrointestinal bleeding 显示文摘 | A1 - Sabah S Barkun AN Herba K | 2008 | Clin Gastroenterol Hepatol2008，6，4： | 1 |
| 13 | Current Imaging of Prenatally Diagnosed Congenital Lung Lesions显示文摘 | Monica E Portia AK Sabah S | 2010 | Semin Ultrasound CT MRI2010，2，31： | 1 |
| 14 | An enhanced-gravity method to recover ultra-fine coal from tailings:Falcon concentrator显示文摘 | ORUF ZGEN S SABAH E | 2010 | Fuel2010，89，9： | 1 |
| 15 | 查看详情显示文摘 | Sabah E Turan M Celik M S | | 0，，16： | 1 |
| 16 | Determination of aspartame and its degradation and epimerization products by capillary electrophoresis显示文摘 | SABAH S SCRIBA G K E | 1998 | Journal of Pharmaceutical and Biomedical Analysis1998，6，： | 1 |
| 17 | Adsorption mechanism of cationic surfactants onto acid-and heat-activated sepiohtes显示文摘 | Sabah E Turan M Celik M S | 2002 | Water Research2002，36，： | 1 |
| 18 | The painful metal-on-metal hip resurfacing显示文摘 | Hart AJ Sabah S Henckel J | | 0，，06： | 1 |
| 19 | S100B as a glial cell marker in diabetic peripheral neuropathy显示文摘 | Celikbilek A Akyol L Sabah S | 2014 | Neurosci Lett2014，558，： | 1 |
| 20 | Interaction of pyridine derivatives with sepiolite 显示文摘 | Sabah E Celik M S | 2002 | Journal of Colloid and Interface Sciences2002，251，1： | 1 |
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