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23篇 您的检索式:作者名="SACK KE"
    题名 作者 年代 出处 被引量
1LPS对BALB/C小鼠肾小管上皮细胞TLR4和TNFα、IL-6表达的影响显示文摘目的探讨TLR4在BALB/C小鼠肾小管上皮细胞(TEC)的表达和内毒素/脂多糖(LPS)刺激后TLR4的变化,以及对产生肿瘤坏死因子α(TNFα)、白细胞介素-6(IL-6)的影响。方法通过RT-PCR方法检测TLR4 mRNA、TNFαm RNA和IL-6 mRNA在TEC的表达;流式细胞术检测TEC的TLR4膜蛋白水平;ELISA检测培养的TEC上清中TNFα、IL-6的含量。结果正常TEC有TLR4 mRNA表达,但TNFα mRNA、IL-6 mRNA表达甚弱。经LPS刺激后,TEC中的TLR4 mRNA、TNFα mRNA和IL-6 mRNA表达均显著增强,TLR4膜蛋白以及培养上清中的TNFα、IL-6水平亦相应增加。结论TLR4在LPS激活的TEC中表达显著增强,同时TEC分泌的炎症因子TNFα、IL-6的水平也相应上调。朱晓玲 Li Ke 王永钧 杨亚珍 Wuding Zhou Steven Sacks 2008医学研究杂志2008,37,1:5
2Treatment of ankylos- ing spondylitis by inhibition of tumor necrosis factor al- pha 显示文摘Gorman JD Sack KE Davis JC Jr 2002The New England Journal of Medicine2002,346,18:1
3Treatment of ankylosing spondylitis byinhibition of tumor necrosis factor a 显示文摘Gorman JD Sack KE Davis JC 2002The New England Jourhal ofMedicine2002,346,:1
4Primary Sjogreng syndrome as a systemic disease : a study of participants enrolled in an intema-tional Sjogren~ syndrome registry 显示文摘Malladi AS Sack KE Shiboski SC 2012Arthritis Care Res (Hoboken)2012,64,6:1
5Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha显示文摘GORMAN JD SACK KE DAVIS JC 2002N Engl J Med2002,346,18:1
6Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha 显示文摘Gorman JD Sack KE Davis JC 2002NEngl J Med2002,346,18:1
7Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha显示文摘Gorman JD Sack KE Davis JC Jr 2002N Engl J Med2002,346,:1
8Primary Sjogren' s syndrome as a systemic disease: a study of participants enrolled in an international Sjogren' s syndrome registry 显示文摘Malladi AS Sack KE Shiboski SC 2012Arthritis Care Res (Hoboken)2012,64,6:1
9Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor 显示文摘Gorman JD Sack KE Davis JC Jr 2002N Engl J Med2002,346,18:1
10Treatment of ankylosiug spondyli- tis by inhibition of tumor necrosis factor c显示文摘Gorman JD Sack KE Davis JC 2002New Engl J Med2002,346,18:1
11Wegener's granulomatosis 显示文摘Sack KE 1989West J Med1989,150,3:1
12Etanercept in the treatment of ankylosing spondylitis:a randomiczed, double-blind, placebo-controlled study显示文摘Gorman JD Sack KE Davis JC 2000Arthritis Rheum2000,43,:1
13When to try COX-2-specific inhibitors:safer than standard NSAIDs in some situations显示文摘Rehman Q Sack KE 1999Postgrad Med1999,106,:1
14Treatment of ankylosing s pongdylitis by inhibition of tumor necrosis factor显示文摘Gorman JD Sack KE Davis JC 2002N Engl J Med2002,346,18:1
15Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha显示文摘Gorman JD Sack KE Davis JC Jr 2002N Engl J Med2002,346,:1
16Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha显示文摘Gorman JD Sack KE Davis JC Jr 0,,18:1
17Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha显示文摘Gorman JD Sack KE Davis JC Jr 2002N Engl J M ed2002,346,2:1
18Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha 显示文摘Gorman JD Sack KE Davis JC 2002N Engl J Med2002,346,18:1
19Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor ct 显示文摘Gorman JD Sack KE Davis JC 2002N EnglJ Med2002,346,12:1
20Treatment of ankylosing s pongdylitis by inhibition of tunor necrosis factor 显示文摘Gorman JD Sack KE Davis JG 2002N Engl J Med2002,346,18:1
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