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| 1 | 亚太地区胃食管反流病的处理共识:更新版显示文摘背景与目的:自从2004年亚太地区胃食管反流病(GERD)共识发表以来,更多关于GERD流行病学和处理的文献资料相继出现。有必要对这些资料进行循证综述,对共识作出更新。方法:由多学科专家组应用德尔菲(Delphi)法制定共识条文,提呈相关资料,并对证据质量、推荐力度和共识水平进行分级。结果:亚洲GERD发生率日益增加。其危险因素包括老年、男性、种族、家族史、社会经济地位高、体重指数增加和吸烟。对于有典型症状而无报警症状的患者,对质子泵抑制剂(PPI)试验有症状应答具有诊断意义。如PPI试验失败,停止治疗后pH监测结果阴性可排除GERD。窄带成像、胶囊内镜检查和无线pH监测的作用尚未明确。亚洲诊断策略的制定须考虑到并存的胃癌和消化性溃疡。减轻体质量和抬高床头可改善反流症状。PPIs是最有效的内科治疗手段。对于非糜烂性反流病(NERD)患者,按需治疗较为适宜。有慢性咳嗽、喉炎和典型GERD症状的患者在排除非GERD病因后,应予PPI每天两次治疗。如有经验丰富的外科医师,GERD患者可行胃底折叠术。除临床试验外,GERD不应采用内镜治疗。结论:新的诊断方法和内镜治疗的作用有待进一步研究阐明。亚洲GERD诊断策略的制定须考虑到并存的胃癌和消化性溃疡。PPIs仍为治疗的基石。 | Kwong Ming Fock Nicholas J Talley Ronnie Fass Khean Lee Goh Peter Katelaris Richard Hunt Michio Hongo Tiing Leong Ang Gerald Holtmann Sanjay Nandurkar San Ren Lin Benjamin CY Wong Francis KL Chan Abdul Aziz Rani Young-Tae Bak Jose Sollano Khek Yu Ho Sathoporn Manatsathit 钱本余 | 2008 | 胃肠病学2008，13，7： | 21 |
| 2 | Perfusion magnetic resonance imaging of the liver显示文摘Perfusion magnetic resonance imaging (MRI) studies quantify the microcirculatory status of liver parenchyma and liver lesions, and can be used for the detection of liver metastases, assessing the effectiveness of antiangiogenic therapy, evaluating tumor viability after anticancer therapy or ablation, and diagnosis of liver cirrhosis and its severity. In this review, we discuss the basic concepts of perfusion MRI using tracer kinetic modeling, the common kinetic models applied for analyses, the MR scanning techniques, methods of data processing, and evidence that supports its use from published clinical and research studies. Technical standardization and further studies will help to establish and validate perfusion MRI as a clinical imaging modality. | Choon Hua Thng Tong San Koh David J Collins Dow Mu Koh | 2010 | World Journal of Gastroenterology2010，16，13： | 15 |
| 3 | Challenges and prospects for consumer acceptance of cultured meat显示文摘Consumer acceptance of cultured meat is expected to depend on a wide diversity of determinants ranging from technologyrelated perceptions to product-specific expectations, and including wider contextual factors like media coverage, public involvement, and trust in science, policy and society. This paper discusses the case of cultured meat against this multitude of possible determinants shaping future consumer acceptance or rejection. The paper also presents insights from a primary exploratory study performed in April 2013 with consumers from Flanders(Belgium)(n=180). The concept of cultured meat was only known(unaided) by 13% of the study participants. After receiving basic information about what cultured meat is, participants expressed favorable expectations about the concept. Only 9% rejected the idea of trying cultured meat, while two thirds hesitated and about quarter indicated to be willing to try it. The provision of additional information about the environmental benefits of cultured meat compared to traditional meat resulted in 43% of the participants indicating to be willing to try this novel food, while another 51% indicated to be ‘maybe' willing to do so. Price and sensory expectations emerged as major obstacles. Consumers eating mostly vegetarian meals were less convinced that cultured meat might be healthy, suggesting that vegetarians may not be the ideal primary target group for this novel meat substitute. Although exploratory rather than conclusive, the findings generally underscore doubts among consumers about trying this product when it would become available, and therefore also the challenge for cultured meat to mimic traditional meat in terms of sensory quality at an affordable price in order to become acceptable for future consumers. | Wim Verbeke Pierre Sans Ellen J Van Loo | 2015 | Journal of Integrative Agriculture2015，14，2： | 10 |
| 4 | 经皮经导管射频消融去肾交感神经术与螺内酯对难治性高血压昼夜节律和血压变异性的影响显示文摘经皮经导管射频消融去肾交感神经术(sympathetic renal denervation,SRD)可作为药物控制不佳的难治性高血压患者的一种替代治疗方法,SRD对减少短期血压变异性(blood pressure variability,BPV)有效。然而,这个作用尚未在随机对照试验中证实。本研究旨在比较螺内酯和SRD对昼夜血压和BPV的影响。方法:对一项随机试验进行析因分析, | de la Sierra A Pareja J Armario P Barrera Yun S Vázquez S Sans L Pascual J Oliveras A 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 5 | Genetic relationships among Spanish sheep using microsatellites显示文摘 | Arranz J J Bayon Y San Primitivo F | 1998 | Animal Genetics1998，29，6： | 2 |
| 6 | Aspects of reproduction in the alpace显示文摘 | Copaira M Zuniga J | 1968 | J Reprod Fertil1968，16，： | 1 |
| 7 | Performance of a serpentine heat exchanger: part Ⅱ second-law efficieney显示文摘 | SAN J Y PAI K L | 2009 | Applied Thermal Engineering2009，29，1415： | 1 |
| 8 | The role of expectations in the consumer satisfaction forma-tion process:Empirical evidence in the travel agency sector显示文摘 | IA Rodriguez del Bosque H San Martin J Collado | 2006 | Tourism Management2006，，27： | 1 |
| 9 | propranolol for severe in- fantile hemangiomas :follow-up report显示文摘 | Sans V dela Roque ED Berge J | 2009 | Pediatrics2009，124，3： | 1 |
| 10 | Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma(MM-003):a randomised,open-label,phase 3trial显示文摘 | San Miguel J Weisel K Moreau P | 2013 | Lancet Oncol2013，14，11： | 1 |
| 11 | Hydrogen storage of ZnO and Mg doped ZnO nanowires显示文摘 | Pan H Luo J San H | 2006 | Nanotechnology2006，17，： | 1 |
| 12 | International staging system for multiple myeloma显示文摘 | Greipp PR San Miguel J Durie BG | 2005 | J Clin Oneol2005，23，： | 1 |
| 13 | Epidemiology and cost of herpes zoster and postherpetic neu? ralgia among patients treated in primary care centres in the valen? cian community of Spain显示文摘 | Cebrian - Cuenca AM Diez - Domingo J San - Martin - Ro- driguez M | 2011 | BMC Intect Dis2011，11，5： | 1 |
| 14 | The spatial distribution of soils across Europe : A fractal approach 显示文摘 | Ibmez J J Prrez-G6mez R San Jos6 F | 2009 | Ecological Com- plexity2009，6，： | 1 |
| 15 | Propranolol for severe infantile hemangiomas: follow-up report显示文摘 | Sans V de la Roque ED Berge J | 2009 | Pediatrics2009，124，3： | 1 |
| 16 | Improving classification per-formance of Support Vector Machine by genetically optimizing ker-nel shape and hyper - parameters 显示文摘 | San L D Rogozan A Pecuchet J P | 2010 | Applied Intelligence2010，36，2： | 1 |
| 17 | Unilateral pulmonary arteryagenesis presentingwith hemoptysis:treatment by embolization of systemic collaterals显示文摘 | Rene M Sans J Dominguez J | 1995 | Cardiovasc Intervent Radio1995，18，4： | 1 |
| 18 | Modeling and testing of a silica gel packed-bed system显示文摘 | San J Y Jiang G D | 1994 | Int J of Heat and Mass Transfer1994，37，8： | 1 |
| 19 | Antimicrobial susceptibility and synergy studies of Stenotrophomonas maltophilia isolates from patients with cystic fibrosis显示文摘 | San Gabriel P Zhou J Tabibi S | 2004 | Antimicrob Agents Chemother2004，48，： | 1 |
| 20 | Modification of the number and phenotype of stfiatal dopaminergic cells by carotid body graft 显示文摘 | San Sebastian W Guillen J Manfigue M | 2007 | Brain2007，130，5： | 1 |
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