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| 1 | Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia显示文摘AIM: To identify the most common hepatitis B virus (HBV) genotype in Saudi Arabia, and correlate the prevailing genotypes with the clinical outcome of patients. METHODS: Patients were consecutively recruited from the hepatology clinics of two tertiary care referral cen- ters. Patients were categorized into 4 different groups: group 1, patients with hepatitis B and normal liver en- zymes; group 2, patients with hepatitis B and abnormal liver enzymes but without cirrhosis; group 3, patients with hepatitis B and liver cirrhosis; group 4, patients with hepatitis B and hepatocellular carcinoma. All patients had a positive hepatitis B surface antigen (HBsAg). Ge- notyping of HBV was performed by nested PCR-mediated amplification of the target sequence and hybridization with sequence-specific oligonucleotides. RESULTS: Seventy patients were enrolled in this study. They were predominantly male (72.9%) in their mid- forty’s (mean age 47 years). Forty-nine (70%) patients were hepatitis B envelope antigen (HBeAg) negative. The majority of patients (64%) acquired HBV through unknown risk factors. Hepatitis B genotyping revealed that 57 patients (81.4%) were genotype D, 1 patient (1.4%) had genotype A, 1 patient (1.4%) had geno- type C, and 4 patients (5.7%) had genotype E, while 7 patients (10%) had mixed genotype (4 patients ADG, 1 patient DE, 1 patient DF, and 1 patient ADFG). Based on univariate analysis of genotype D patients, significant predictors of advanced liver disease were age, gender, aspartate transaminase, alanine transaminase, albumin,bilirubin, and alkaline phosphatase (all P < 0.001). In multivariate analysis decreased hemoglobin (r = -0.05; 95% CI: -0.08 to -0.03; P = 0.001) and albumin levels (r = -0.004; 95% CI: -0.007 to -0.001; P = 0.002) were highly significant predictors of advanced liver disease. In patients with HBV genotype D, HBeAg negativity was found to increase across advancing stages of liver dis- ease (P = 0.024). CONCLUSION: This study highlights that the vast ma- jority of Saudi patients with chronic hepatitis B have genotype D. No correlation could be observed between the different genotypes and epidemiological or clinical factors. The relationship between genotype D and HBeAg status in terms of disease severity needs to be further elucidated in larger longitudinal studies. | Ayman A Abdo Badr M Al-Jarallah Faisal M Sanai Ahmad S Hersi Khalid Al-Swat Nahla A Azzam Manal Al-Dukhayil Amira Al-Maarik Faleh Z Al-Faleh | 2006 | World Journal of Gastroenterology2006，12，43： | 7 |
| 2 | Six Minute Walk Test to assess functional capacity in chronic liver disease patients显示文摘AIM: To examine the utility of Six Minute Walk Test (6MWT) in patients with chronic liver disease (CLD). METHODS: Two hundred and fifty subjects between the ages of 18 and 80 (mean 47) years performed 6MWT and the Six Minute Walk Distance (6MWD) was measured. RESULTS: The subjects were categorized into four groups. Group A (n = 45) healthy subjects (control); group B (n = 49) chronic hepatitis B patients; group C (n = 54) chronic hepatitis C patients; group D (n = 98) liver cirrhosis patients. The four groups differed in terms of 6MWDs (P < 0.001). The longest distance walked was 421 ± 47 m by group A, then group B (390 ± 53 m), group C (357 ± 72 m) and group D (306 ± 111 m). The 6MWD correlated with age (r = -0.482, P < 0.01), hemoglobin (r = +0.373, P < 0.001) and albumin (r = +0.311, P < 0.001) levels. The Child-Pugh classification was negatively correlated with the 6MWD in cirrhosis (group D) patients (r = -0.328, P < 0.01). At the end of a 12 mo follow-up period, 15 of the 98 cirrhosis patients had died from disease complications. The 6MWD for the surviving cirrhotic patients was longer than for non-survivors (317 ± 101 vs 245 ± 145 m, P = 0.021; 95% CI 11-132). The 6MWD was found to be an independent predictor of survival (P = 0.024). CONCLUSION: 6MWT is a useful tool for assessing physical function in CLD patients. We suggest that 6MWD may serve as a prognostic indicator in patients with liver cirrhosis. | Hatem F Alameri Faisal M Sanai Manal Al Dukhayil Nahla A Azzam Khalid A Al-Swat Ahmad S Hersi Ayman A Abdo | 2007 | World Journal of Gastroenterology2007，13，29： | 5 |
| 3 | Neural stem cells and the origin of gliomas 显示文摘 | Sanai N Alvarez-Buylla A Berger MS | 2005 | N Engl J Med2005，353，8： | 1 |
| 4 | Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration显示文摘 | SANAI N TRAMONTIN A D QUINONES-HINOJOSA A | 2004 | Nature2004，427，6926： | 1 |
| 5 | Effects of bathymetry,friction,and rotation on estuary-ocean exchange显示文摘 | VALLE-LEVINSON A REYES C SANAY R | 2003 | Journal of Physical Oceanography2003，33，11： | 1 |
| 6 | Wind-induced circulation in semienclosed homogeneous,rotating basins显示文摘 | SANAY R VALLE-LEVINSON A | 2005 | Journal of Physical Oceanography2005，35，12： | 1 |
| 7 | Unique as trocyte ribbon in adult human brain contains neural stem cells but lacks chain migration显示文摘 | Sanai N Tramontin AD Quinones-Hinojosa A | 2004 | Nature2004，427，6976： | 1 |
| 8 | Extensive interstitial collagen deposition on the basement membrane zone in allergic nasal mucosa显示文摘 | Sanai A Nagata H Konno A | 1999 | Acta Otolaryngol1999，119，4： | 1 |
| 9 | Extensive in-terstitial collagen deposition on the basement mem-brane zone in allergic nasal mucosa显示文摘 | SANAI A NAGATA H KONNO A | 1999 | Acta Otolar-yngol1999，119，： | 1 |
| 10 | Combined microsurgical and endovascular management of complex intracranial aneurysms显示文摘 | Lawton MT Quinones-Hinojosa A Sanai N | 2003 | Neurosurgery2003，52，2： | 1 |
| 11 | Neural stem ceils and the origin of gliomas 显示文摘 | Sanai N Alvarez-Buylla A Berger MS | 2005 | N Engl J Med2005，353，： | 1 |
| 12 | ARhabdomyolysis andunilateral renal infarction after a motor vehicle crash显示文摘 | Sanai T Yokoyama M Murata A | 2007 | Angiology2007，58，4： | 1 |
| 13 | Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration显示文摘 | Sanai N Tramontin AD Quinones-Hinojosa A | 2004 | Nature2004，427，6976： | 1 |
| 14 | Techniques to as- sess the proliferative potential of brain tumors 显示文摘 | Quinones-Hinojosa A Sanai N Snfith J S | 2005 | J Neurooncol2005，74，1： | 1 |
| 15 | Pediatry, intracranial aneurysms: durability of treatment following microsurgical and endovascular management 显示文摘 | Sanai N Quinones-Hinojosa A Gupta NM et at | 2006 | J Neurosurg2006，104，2： | 1 |
| 16 | Combined micro- surgical and endovascular management of complex intracranial aneu- rysms 显示文摘 | Lawton M T Quinones-Hinojosa A Sanai N | 2008 | Neurosurgery2008，62，63： | 1 |
| 17 | Neural stem cells and the origin of gliomas显示文摘 | Sanai N Alvarez-BuyUa A Berger MS | | N EnglJ Med0，353，8： | 1 |
| 18 | Techniques to assess the proliferative potential of brain tumors显示文摘 | OUINONES-HINOJOSA A SANAI N SMITH J S | 2005 | J Neurooncol2005，74，1： | 1 |
| 19 | Cellular composition and cytoarchitecture of the adult human subventricular zone : a niche of neural stem cells显示文摘 | Quinones-Hinojosa A Sanai N Soriano-Navarro M | 2006 | J Comp Neurol2006，494，3： | 1 |
| 20 | Combined microsurgical and endovascular management of complex intracranial aneurysms 显示文摘 | Lawton MT Quinones-Hinojosa A Sanai N | 2003 | Neurosurgery2003，52，2： | 1 |
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