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| 1 | B7 homologue 3 as a prognostic biomarker and potential therapeutic target in gastrointestinal tumors显示文摘The most common digestive system(DS)cancers,including tumors of the gastrointestinal tract(GIT)such as colorectal cancer(CRC),gastric cancer(GC)and esophageal cancer(EC)as well as tumors of DS accessory organs such as pancreatic and liver cancer,are responsible for more than one-third of all cancerrelated deaths worldwide,despite the progress that has been achieved in anticancer therapy.Due to these limitations in treatment strategies,oncological research has taken outstanding steps towards a better understanding of cancer cell biological complexity and heterogeneity.These studies led to new molecular target-driven therapeutic approaches.Different in vivo and in vitro studies have revealed significant expression of B7 homologue 3(B7-H3)among the most common cancers of the GIT,including CRC,GC,and EC,whereas B7-H3 expression in normal healthy tissue of these organs was shown to be absent or minimal.This molecule is able to influence the biological behavior of GIT tumors through the various immunological and nonimmunological molecular mechanisms,and some of them are shown to be the result of B7-H3-related induction of signal transduction pathways,such as Janus kinase 2/signal transducer and activator of transcription 3,phosphatidylinositol 3-kinase/protein kinase B,extracellular signal-regulated kinase,and nuclear factor-κB.B7-H3 exerts an important role in progression,metastasis and resistance to anticancer therapy in these tumors.In addition,the results of many studies suggest that B7-H3 stimulates immune evasion in GIT tumors by suppressing antitumor immune response.Accordingly,it was observed that experimental depletion or inhibition of B7-H3 in gastrointestinal cancers improved antitumor immune response,impaired tumor progression,invasion,angiogenesis,and metastasis and decreased resistance to anticancer therapy.Finally,the high expression of B7-H3 in most common cancers of the GIT was shown to be associated with poor prognosis.In this review,we summarize the established data from different GIT cancer-related studies and suggest that the B7-H3 molecule could be a promising prognostic biomarker and therapeutic target for anticancer immunotherapy in these tumors. | Petar Rasic Maja Jovanovic-Tucovic Marija Jeremic Slavisa M Djuricic Zorica V Vasiljevic Maja Milickovic Djordje Savic | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 2 |
| 2 | Single nucleotide polymorphisms in multiple sclerosis: disease susceptibility and treatment response biomarkers显示文摘 | Pravica V Popadic D Savic E | 2012 | Immunol Res2012，52，12： | 1 |
| 3 | A study of HAp/ PLLA composite as a substitute for bone powder using FTIR spectroscopy显示文摘 | Ignjatovic N Savic V Najman S | 2001 | Biomaterials2001，22，： | 1 |
| 4 | p H control and the production of extracellular dextransucrase by Leuconostoc mesenteroides显示文摘 | LAZIC M VELJKOVIC V SAVIC D | 1991 | World Journal of Microbiology and Biotechnology1991，7，1： | 1 |
| 5 | Nephroprotective effects of pentoxifylline in experimental myoglobinuric acute renal failure显示文摘 | Savic V Vlahovic P Djordjevic V | 2002 | Pathol Biol (Paris)2002，50，10： | 1 |
| 6 | Intergenerational changes of CTG repeat depending on the sex of the transmitting parent in myotonic dystrophy type 1显示文摘 | Rakocevic-Stojanovic V Savic D Pavlovic S | 2005 | Eur J Neurol2005，12，： | 1 |
| 7 | Characterization of plasma magnesium concentration and oxidative stress following graded traumatic brain injury in humans 显示文摘 | Cernak I Savic V J Kotur J | 2000 | Journal of neurotrauma2000，17，1： | 1 |
| 8 | Biological evaluation of hydroxyapatite/poly-L-lactide composite biomaterials with poly-L-lactide of different molecular weights intraperitonealy implanted into mice显示文摘 | Najman S Dordevic L J Savic V | 2004 | Biomed Mater Eng2004，14，： | 1 |
| 9 | Neuroendocrine responses following graded traumatic brain injury in male adults 显示文摘 | Cernak I Savic V J Lazarov A | 1999 | Brain Inj1999，13，12： | 1 |
| 10 | TRIP12and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes显示文摘 | GUDJONSSON T ALTMEYER M SAVIC V | 2012 | Cell2012，150，4： | 1 |
| 11 | Neuroendocrine responses following graded traumatic brain injury in male adults显示文摘 | CERNAK I SAVIC V J LAZAROV A | 1999 | Brain Inj1999，13，12： | 1 |
| 12 | The role of partial cystectomy in treatment of muscle invasive bladder cancer显示文摘 | Vukotic V Lazic M Savic S | 2007 | Acta Chir Iugosl2007，54，4： | 1 |
| 13 | Structural Evaluation of an Experimental Aluminum/Magnesium Decklid显示文摘 | Carter J T Melo A R Savic V | | 0，，01： | 1 |
| 14 | Myelodysplastic syndromes in adults aged less than 50 years: incidence and clinicopathological data显示文摘 | Marisavljevic D Savic A Zeremski V | 2014 | J BUON2014，19，4： | 1 |
| 15 | A Study of Hap/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy显示文摘 | Ignjatovic N Savic V Najman S | 2001 | Biomaterials2001，22，： | 1 |
| 16 | A Study of HAp/PLLA composite as a substitute for bone powder, using FT-IR spectroscopy显示文摘 | Ignjatovic N Savic V Najman S | 2001 | Biomaterials2001，22，： | 1 |
| 17 | Uniformly reweighted belief propagation for estimation and detection in wireless networks显示文摘 | Wymeersch H Penna F and Savic V | 2012 | IEEE Transactions on Wireless Communications2012，11，4： | 1 |
| 18 | Enteritis assiated with Clo- stridium peCringens type A in 9 month old calves 显示文摘 | Savic B Prodanovie R Ivetic V | 2012 | The Canadian Veterinary Journal2012，53，2： | 1 |
| 19 | The role of partial cystectomy in treatment of muscle invasive bladder cancer显示文摘 | Vukotic V Lazic M Savic S | 2007 | Acta Chir Iugosl2007，54，4： | 1 |
| 20 | Genetic diversity of My- coplasma hyopneumoniae isolates from conventional farrow-to- finish pig farms in Serbia显示文摘 | Savic B Ivetic V Milicevic V | 2010 | Acta Vet Hung2010，58，3： | 1 |
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