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| 1 | Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw显示文摘Bacterial biofilms have emerged as potential critical triggers in the pathogenesis of bisphosphonate(BP)-related osteonecrosis of the jaw(ONJ) or BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of these difficult to cultivate and presents many clinical challenges. The purpose of this study was to characterize the bacterial diversity in BRONJ lesions and to determine host immune response. We examined tissue specimens from three cohorts(n530); patients with periodontal disease without a history of BP therapy(Control, n510), patients with periodontal disease having history of BP therapy but without ONJ(BP, n55) and patients with BRONJ(BRONJ, n515). Denaturing gradient gel electrophoresis of polymerase chain reaction(PCR)-amplified 16 S r RNA gene fragments revealed less bacterial diversity in BRONJ than BP and Control cohorts. Sequence analysis detected six phyla with predominant affiliation to Firmicutes in BRONJ(71.6%), BP(70.3%) and Control(59.1%). Significant differences(P,0.05) in genera were observed, between Control/BP, Control/BRONJ and BP/BRONJ cohorts. Enzyme-linked immunosorbent assay(ELISA)results indicated that the levels of myeloperoxidase were significantly lower, whereas interleukin-6 and tumor necrosis factor-alpha levels were moderately elevated in BRONJ patients as compared to Controls. PCR array showed significant changes in BRONJ patients with downregulation of host genes, such as nucleotide-binding oligomerization domain containing protein 2, and cathepsin G, the key modulators for antibacterial response and upregulation of secretory leukocyte protease inhibitor, proteinase 3 and conserved helix–loop–helix ubiquitous kinase. The results suggest that colonization of unique bacterial communities coupled with deficient innate immune response is likely to impact the pathogenesis of ONJ. | Smruti Pushalkar Xin Li Zoya Kurago Lalitha V Ramanathapuram Satoko Matsumura Kenneth E Fleisher Robert Glickman Wenbo Yan Yihong Li Deepak Saxena | 2014 | International Journal of Oral Science2014，6，4： | 4 |
| 2 | Comparative evaluation of megadose methylprednisolone with dexamethasone for treatment of primary optic neuritis 显示文摘 | Menon V Mehrotra A Saxena R | 2007 | Indian J Opthalmol2007，55，5： | 1 |
| 3 | Synthesis and properties of polyether nitrile copolymers with pendant methyl groups显示文摘 | Saxena A Rao V L Ninan K N | 2003 | European Polymer Journal2003，39，： | 1 |
| 4 | Improved foreign gene expression in plants using a virus-encoded suppressor of RNA silencing modified to be developmentally harmless显示文摘 | Saxena P Hsieh Y C Alvarado V Y | 2011 | Plant BiotechnolJ2011，9，6： | 1 |
| 5 | Synthesis and properties of polyarylene ether nitrile copolymers 显示文摘 | Saxena A Sadhana R Rao V L | 2003 | Polym Bull2003，0，： | 1 |
| 6 | Pontine tuberculoma presenting with horizontal gaze palsy显示文摘 | Saxena R Menon V Sinha A | 2006 | J Neuroophthalmol2006，26，4： | 1 |
| 7 | Vscuum- assisted closure: microdeformations of wounds and cell proliferation显示文摘 | Saxena V Hwang CW Huang S | 2004 | Plast Reconstr Surg2004，114，5： | 1 |
| 8 | Isolation and study of the aurone glycoside leptosin from the leaves of Fiemingla strobilifera 显示文摘 | Nigam S S Saxena V K | 1975 | Planta Med1975，27，： | 1 |
| 9 | Lincomycin anewer antibiotic against resistant strains of Staphylococci显示文摘 | Pratap V K Kunwar M Saxena H | 1997 | Clinician1997，41，1： | 1 |
| 10 | Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels显示文摘 | Saxena R Voight BF Lyssenko V | | 0，，5829： | 1 |
| 11 | Effects of load ratio and temperature on the near-threshold fatigue crack propagation behavior in a CrMoV steel 显示文摘 | LIAW P K SAXENA A SWAMINATHAN V P | 1983 | Metallurgical Transaction A1983，，： | 1 |
| 12 | Synthesis and prop- erties of polyether nitrile copolymers with pendant methyl groups 显示文摘 | Saxena A Rao V L Ninan K N | 2003 | European Polymer Journal2003，39，： | 1 |
| 13 | Vacuum-assisted closure:microdeformations of wounds and cell proliferation显示文摘 | Saxena V Hwang CW Huang S | 2004 | Plast Reconstr Surg2004，114，5： | 1 |
| 14 | Synthesis and properties of poly ether nitrile copolymers with pendant methyl groups 显示文摘 | SAXENA A RAO V L NINAN K N | 2003 | Eur Polym J2003，39，： | 1 |
| 15 | Effect of squealer geometry on tip flow and heat transfer for a turbine blade in a low speed cascade显示文摘 | SAXENA V EKKAD S V | 2004 | ASME Journal of Turbomachinery2004，126，4： | 1 |
| 16 | Efficiency enhancement in dye sensitized solar cells through co-sensitization of TiO2 nanocrystalline electrodes显示文摘 | Saxena V Veerender P Chauhan A K | 2012 | Appl Phys Lett2012，100，13： | 1 |
| 17 | Prospects of conducting polymers in molecular electronics显示文摘 | V Saxena B D Malhotra | 2003 | Current Applied Physics2003，3，23： | 1 |
| 18 | Hierarchical key man-agement scheme using polynomial interpolation 显示文摘 | Das M L?Saxena A Gulati V P | 2005 | SIGOPSoper syst rev2005，39，1： | 1 |
| 19 | Post-natal paucity of regulatory T cells and control of NK cell activation in experimental biliary atresia显示文摘 | Miethke AG Saxena V Shivakumar P | | 0，，05： | 1 |
| 20 | Bilateral luxatio erecta with greater tuberosity fracture:a case report显示文摘 | Saxena V Pradhan P | 2013 | J Clin Orthop Tranma2013，4，4： | 1 |
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