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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma显示文摘到真菌的促进感受性经常导致是特别地困难的临床上设法的气喘的一种严重形式,导致在这些病人的增加的病态和住院。尽管 B 淋巴细胞可能通过 IgE 的生产加重气喘症状,这些房间可能也在对吸入的真菌的保护的反应是重要的。通过 cytokine 版本和 T 房间相互作用,这些淋巴细胞可能也影响航线墙纤维变性的发展和维护。J H −/− 老鼠为抗体的重链部件缺乏 JH 基因,它为 B 房间功能和幸存是批评的。这些动物在很多有免疫力的回答便于 B 淋巴细胞的角色的说明;然而, J H −/− 老鼠没被用来学习真菌的过敏症。在这研究,我们用曲霉属菌 fumigatus 检验了 B 淋巴细胞的角色模仿被环境真菌的暴露触发的人的航线疾病的鼠科的真菌的高空过敏症模型。我们在敏化的野类型的 BALB/c 和 J 暴露于的 H −/− 老鼠重复了真菌的暴露并且没在大航线附近在航线 hyperresponsiveness,全面肺的发炎或骨胶原免职发现差别。然而, Th2 类型 cytokines IL-4 和 IL-13 的层次显著地在 J 相对 BALB/c 控制的 H −/− 鼠标。由对比,煽动性的 cytokines IL-17A 和 IL-6 的层次显著地在 J H −/− 动物,并且有显著地更柔韧的航线嗜曙红血球过多和 neutrophilia 比在控制动物。一起拿,这些调查结果表明淋巴细胞帮助在肺的分隔空间调整 granulocytic 回答到真菌的暴露的那 B。 | Sumit Ghosh Scott A Hoselton Scott V Asbach Breanne N Steffan Steve B Wanjara Glenn P Dorsam Jane M Schuh | 2015 | Cellular & Molecular Immunology2015，12，2： | 2 |
| 3 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders显示文摘 | E Joanna Baxter Linda M Scott Peter J Campbell Clare East Nasios Fourouclas Soheila Swanton George S Vassiliou Anthony J Bench Elaine M Boyd Natasha Curtin Mike A Scott Wendy N Erber Anthony R Green | 2005 | The Lancet . 2005 (9464)2005，，： | 2 |
| 4 | A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia显示文摘This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia.All cases at a single center between 2012 and 2016 were included.Operative approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm extraction.Blastocyst culture was exclusively utilized prior to transfer.The primary outcome was live birth rate.Secondary outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was performed.Seventy-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were analyzed.The live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no different.Pregnancy rates were no different through the first transfer cycle.However,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per patient.Thus,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort. | Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis Richard T Scott Jr James M Hotaling | 2020 | Asian Journal of Andrology2020，22，2： | 2 |
| 5 | Specific criteria for selection of alloy compositions for bulk metallic glasses显示文摘 | Senkov O N Scott J M | 2004 | Scripta Materialia2004，50，： | 1 |
| 6 | Reactions of arsenic (Ⅲ)and arsenic (Ⅴ) species with glutathione显示文摘 | Scott N Hatlelid K M MacKenzie N E | 1993 | Chem Res Toxicol1993，6，： | 1 |
| 7 | Low temperature mechanical properties of scandium-modified Al-Zn-Mg-Cu alloys显示文摘 | SENKOY O N MIRACLE D B MILMAN Y V SCOTT J M LOTSKO D V SIRKO A I | 2002 | Materials Science Forum2002，，： | 1 |
| 8 | Salt Splitting in a Three-compartment Membrane Electrolysis Cell显示文摘 | Tzanetakis N Taama W M Scott K | 2002 | Filtration and Separation2002，39，3： | 1 |
| 9 | Takotsubo cardiomyop-athy: a diagnostic challenge显示文摘 | Zeb M Sambu N Scott P | 2011 | Postgrad Med J2011，87，1023： | 1 |
| 10 | Stress-strain be- havior of concrete confined by overlapping hoops at low and high strain rates 显示文摘 | Scott B D Park R Priestley M J N | 1982 | ACI Journal1982，79，1： | 1 |
| 11 | Stress-Strain Behavior of Concrete Confine by Overlapping Hoops at Low and High Strain Rates显示文摘 | Scott B D Park R Priestley M J N | 1982 | ACI Journal1982，79，2： | 1 |
| 12 | The significance of metal hyeraccumalation for biotc interactions 显示文摘 | ROBERT S B SCOTT N M | 1998 | Chem Ecology1998，8，： | 1 |
| 13 | Sequence-tagged site markers for mic- rosatellite : simplified techniques for rapidly obtaining flanking sequences 显示文摘 | Thomas M R Scott N S | 1994 | Planr Mol Biol Rep1994，12，： | 1 |
| 14 | Stress-strain behavior of concrete confined by overlapping hoops at low and high strain rates显示文摘 | Scott B D Park R Priestley M J N | 1982 | ACI Journal1982，79，1： | 1 |
| 15 | Nerve growth factor mRNA and protain levels measured in the same tissue from normal and Alzheimer's disease parietal cortex prain显示文摘 | Scott SA Jette N | 1996 | Res Mol Brain Res1996，42，1： | 1 |
| 16 | Immunity and protection against Brucella abortus 显示文摘 | Golding B Scott DE Scharf 0 Huang LY Zaitseva M Lapham C Eller N Golding H | 2001 | Microbes Infect2001，3，1： | 1 |
| 17 | In vitro physiologically based extraction test (PBET) and bioaccessibility of arsenic and lead from various mine waste materials显示文摘 | Scott B Barry N Vitukawalu M | 2007 | J Toxicol Environ Health : Part A2007，70，： | 1 |
| 18 | Patterns of attentional deficits and emotional bias in bipolar and major depressive disorder显示文摘 | Kerr N Scott J Phillips M L | 2005 | British Journal of Clinical Psychology2005，44，3： | 1 |
| 19 | Displacement of mandibular fractures: Is there a correlation with sensory loss and recovery 显示文摘 | Scott RA Teo N Perry M | 2014 | International journal of oral and maxillofacial surgery2014，43，5： | 1 |
| 20 | Stress-strain Behavior of Concrete Confined by Overlapping Hoops at Low and High Strain Rates显示文摘 | Scott B D Park R Priestley M J N | 1982 | ACI Structure Journal1982，79，1： | 1 |
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