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| 1 | Miniature gastrointestinal endoscopy: Now and the future显示文摘Since its original application,gastrointestinal(GI)endoscopy has undergone many innovative transformations aimed at expanding the scope,safety,accuracy,acceptability and cost-effectiveness of this area of clinical practice.One method of achieving this has been to reduce the caliber of endoscopic devices.We propose the collective term“Miniature GI Endoscopy”.In this Opinion Review,the innovations in this field are explored and discussed.The progress and clinical use of the three main areas of miniature GI endoscopy(ultrathin endoscopy,wireless endoscopy and scanning fiber endoscopy)are described.The opportunities presented by these technologies are set out in a clinical context,as are their current limitations.Many of the positive aspects of miniature endoscopy are clear,in that smaller devices provide access to potentially all of the alimentary canal,while conferring high patient acceptability.This must be balanced with the costs of new technologies and recognition of device specific challenges.Perspectives on future application are also considered and the efforts being made to bring new innovations to a clinical platform are outlined.Current devices demonstrate that miniature GI endoscopy has a valuable place in investigation of symptoms,therapeutic intervention and screening.Newer technologies give promise that the potential for enhancing the investigation and management of GI complaints is significant. | John J McGoran Mark E McAlindon Prasad G Iyer Eric J Seibel Rehan Haidry Laurence B Lovat Sarmed S Sami | 2019 | World Journal of Gastroenterology2019，25，30： | 4 |
| 2 | Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling显示文摘Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D,1,25-dihydroxy-vitamin D [1,25(OH)2 D] are mediated through binding to the vitamin D receptor(VDR). Here,we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad(MDA-MB-231),subcutaneously(PC3) or intra-tibially(both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls.These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/β-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1,interleukin-6(IL-6), and IL-8. Stabilization of β-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer. | Yu Zheng Trupti Trivedi Ruby CY Lin Colette Fong-Yee Rick Nolte Jeline Manibo Yunzhao Chen Musharraf Hossain Konstantin Horas Colin Dunstan Hong Zhou Markus J Seibel | 2017 | Bone Research2017，5，3： | 4 |
| 3 | InterlabOratory variation of bio-chemical markers of bone turnover显示文摘 | Seibel M J Lang M Geilenkenser W J | | 0，，： | 1 |
| 4 | Impacts of ocean acidification on marine fauna and ecosystem processes 显示文摘 | Fabry V J Seibel B A Feely R A | 2008 | ICES Journal of Marine Sci ence2008，65，3： | 1 |
| 5 | Femtosecond laser capsulotomy显示文摘 | FRIEDMAN N J PALANKER DV SCHUELE G ANDERSEN D MARCELLINO G SEIBEL BS | 2011 | J Cataract Refract Surg2011，37，7： | 1 |
| 6 | Insights intopolymer versus oligosaccharide synthesis: mutagenesis and mechanisticstudies of a novel levansucrase from Bacillus megaterium 显示文摘 | Homann A Biedendieck R Gotze S Jahn D Seibel J | 2007 | Biochem J2007，407，： | 1 |
| 7 | A new flux and stator resistance identifier for AC drive systems 显示文摘 | KERKMAN R J SEIBEL B J ROWAN T M | 1996 | IEEE Transactions on Industry Applications1996，32，3： | 1 |
| 8 | Impacts of ocean acidifi- cation on marine fauna and ecosystem processes 显示文摘 | Fabry V J Seibel B A Feely R A | 2008 | ICES Journal of Marine Science2008，65，： | 1 |
| 9 | Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNA(Lys) mutation显示文摘 | Shoffner J M M T Lott A M Lezza P Seibel S W Bollinger D C Wallace | 1990 | Cell1990，，6： | 1 |
| 10 | Chronic progressive external ophthalmoplegia is associated with a novel mutation in the mitochondrial tRNA(Asn) gene显示文摘 | Seibel P Lauber J Klopstock T et a1 | 1994 | Biochem Biophys Res Commun1994，204，2： | 1 |
| 11 | Therapy insight: the risks and benefits of bisphosphonates for the treatment of tumor: induced bone disease显示文摘 | Dunstan C R Felsenberg D Seibel M J | 2007 | Nat Clin Pract Oncol2007，4，1： | 1 |
| 12 | Impacts of ocean acidification on marine fauna and ecosystem processes显示文摘 | Fabry V J Seibel B A Feely R A | 2008 | ICES Journal of Marine Science:Journal du Conseil2008，65，3： | 1 |
| 13 | The rate of metabolism in marine animals: environmental constraints, ecological demands and energetic opportunities 显示文摘 | Seibel B A Drazen J C | 2007 | Philosophical Transactions of the Royal Society B2007，362，1487： | 1 |
| 14 | Synthesis of sucrose analogues and the mechanism of action of Bacillus subtilis fructosyltransferase (lcvansucrase) 显示文摘 | SEIBEL J MORARU R G TZE S | 2006 | Carbohydrate Research2006，341，： | 1 |
| 15 | The bone-protective effect of the phytoestrogen genistein is mediated via ER α-dependent mechanisms and strongly enhanced by physical activity显示文摘 | Hertrampf T Gruca M J Seibel J | 2007 | Bone2007，40，6： | 1 |
| 16 | Serum uric acid plays a protective role for bone loss in peri- and postmenopausal women: a longitudinal study显示文摘 | Makovey J Macara M Chen J S Hayward C S March L Seibel M J | 2013 | Bone2013，52，： | 1 |
| 17 | Anti-crosslinking properties of carnosine: Significance of histidine 显示文摘 | Laura J H Ines Seibel George S | 2004 | Life science2004，75，13： | 1 |
| 18 | Serum bone sialoprotein in patients with primary breast cancer is a prognostic marker for subsequent bone metastasis显示文摘 | Diel I J Solomayer E F Seibel M J | 1999 | Clin Cancer Res1999，5，12： | 1 |
| 19 | The Effect of Intranasal Salmon Calcitonin on Postmenopausal Bone Turnover as Assessed by Biochemical Markers:Evidenee of Maximal Effect after 8 Weeks of Continuous Treatment 显示文摘 | Kraenzlin M E Seibel M J Trechsel U | 1996 | CalcifTissue Int1996，，58： | 1 |
| 20 | A simplified inverter model for on-line control and simulation 显示文摘 | Kerkman R J Seibel B J Bord D ~ | 1991 | IEEE Transactions on Industry Applications1991，27，3： | 1 |
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