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| 1 | Functional roles and clinical values of insulin-like growth factor-binding protein-5 in different types of cancers显示文摘Insulin-like growth factor-bindin g proteins (IGFBPs) are critical regulators of the mitogenic activity of insulin-like growth factors (IGFs). IGFBP5, one of these IGFBPs, has special structural features, including a nuclear transport domain, heparin-binding motif, and IGF/extracellular matrix/acid-labile subunit-binding sites. Furthermore, IGFBP5 has several functional effects on carcinogenesis and even normal cell processes, such as cell growth, death, motility, and tissue remodeling. These biological effects are sometimes related with IGF (IGF-dependent effects) and sometimes not (IGF-independent effects). The functional role of IGFBP5 is most likely determined in a cell-type and tissue-type specific manner but also depends on cell context, especially in terms of the diversity of interacting proteins and the potential for nuclear localization. Clinical findings show that IGFBP5 has the potential to be a useful clinical biomarker for predicting response to therapy and clinical outcome of cancer patients. In this review, we summarize the functional diversity and clinical importance of IGFBP5 in different types of cancers. | Gökçe Güllü Sevgi Karabulut Mustafa Akkiprik | 2012 | Chinese Journal of Cancer2012，31，6： | 8 |
| 2 | An unusual cause of cholecystitis:Heterotopic pancreatic tissue in the gallbladder显示文摘Gallbladder localization of heterotopic pancreas (HP) is uncommon and very rarely gives rise to symptoms. Herein we report a case of HP found in the gallbladder neck presented with signs and symptoms of cholecystitis. The patient was a 40-year old male, suffering from epigastric pain, abdominal fullness and fever. On physical examination, the right upper abdomen was tender with a positive Murphy’s sign. Ultrasonographic examination showed a hydropic gallbladder without stones and he underwent a cholecystectomy. Pathological examination revealed an intramural nodule (9 mm) in the neck region which is consisted of acini, ducts and islet cells of an aberrant pancreatic tissue. Although HP is encountered rarely in the gallbladder and is found incidentally during pathological studies, this case emphasizes that HP might cause symptoms and present clinically as cholecystitis. For this reason, in patients presenting with symptomatic gallbladder diseases, including cholecystitis without any other pathology, HP should be taken into consideration before it is diagnosed as 'idiopathic’’. | Glsm zlem Elpek Sevgi Bozova Gkben Y■d■r■m Kpesiz Mehmet ■■ | 2007 | World Journal of Gastroenterology2007，13，2： | 2 |
| 3 | e-Government adoption model based on the theory of planned behavior:Empirical val- idation显示文摘 | Sevgi O Irfan E K | 2011 | Government Information Quarterly2011，16，8： | 1 |
| 4 | Biological activities and chemical composition of three honeys of different typea from Anatolia显示文摘 | Murat K Sevgi K Sengul K | 2007 | Food Chemistry2007，100，： | 1 |
| 5 | Does caffeine bind to metal ions显示文摘 | SEVGI K MIRAC O MURAT K | 2004 | Food Chemistry2004，84，3： | 1 |
| 6 | Adsorption of Cd( lI ), Cr(1111) and Mn( II ) on natural sepiolite 显示文摘 | Sevgi K | 2009 | Desalination2009，244，13： | 1 |
| 7 | Dimensions of mental health: Life satisfaction, anxiety and depression: A preventive mental health study in Ankara University students population显示文摘 | Sevgi G Temel K Murat B | 2010 | Procedia So- cial and Behavioral Sciences2010，2，： | 1 |
| 8 | Effects of G-CSF 'eatment on neutrophil mobilization and neurological outcome after transient foc- al ischemia显示文摘 | Jan K S Sevgi S Matthias S | 2010 | Experimental Neurology2010，222，： | 1 |
| 9 | Dimensions of mental health: Life satisfaction, anxiety and depression: A preventive mental health study in Ankara University students population 显示文摘 | Sevgi G Temel K Murat B | 2010 | Procedia Social and Behavioral Sciences2010，11，2： | 1 |
| 10 | 电子记录管理系统可用性评价:以哈西德佩大学为例显示文摘以管理分类、归档、访问等过程为目的,基于权限和跟踪访问而建立电子记录管理系统(Electronic Document Management Systems,EDMS)。土耳其TSE 13298标准规定了EDMS软件应具有的特性和功能,但不容忽视的是,这些系统是由人管理和使用的,而人与计算机交互的定性和定量结果能够告诉我们一个系统是否可用。本研究的目的是通过对EDMS提供启发式分析(Heuristic Analysis)和服务器日志分析(Server Log Analysis),找出影响EDMS可用性的因素,并提出建议来纠正非正常的接口设计元素。本研究梳理了最常用的启发性评估原则,以此来对30台电脑的可用性进行评价,同时对Apache服务器中的1600万行错误记录和访问日志记录进行了加工和分析,以处理系统的使用信息。 | Sevgi Koyuncu Tun? ?zgür Külcü 李思艺 张晨旭 | 2017 | 浙江档案2017，，8： | 0 |
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