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| 1 | Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy显示文摘AIM: To examine DNA methylation profiles in a longitudinal comparison of pre-diabetes mellitus(Pre-DM) subjects who transitioned to type 2 diabetes mellitus(T2DM).METHODS: We performed DNA methylation study in bisulphite converted DNA from Pre-DM(n = 11) at baseline and at their transition to T2 DM using Illumina Infinium Human Methylation27 Bead Chip, that enables the query of 27578 individual cytosines at Cp G loci throughout the genome, which are focused on the promoter regions of 14495 genes.RESULTS: There were 694 Cp G sites hypomethylated and 174 Cp G sites hypermethylated in progression from Pre-DM to T2 DM, representing putative genes involved in glucose and fructose metabolism, inflammation, oxidative and mitochondrial stress, and fatty acid metabolism. These results suggest that this high throughput platform is able to identify hundreds of prospective Cp G sites associated with diverse genes that may reflect differences in Pre-DM compared with T2 DM. In addition, there were Cp G hypomethylation changes associated with a number of genes that may be associated with development of complications of diabetes, such as nephropathy. These hypomethylation changes were observed in all of the subjects.CONCLUSION: These data suggest that some epigenomic changes that may be involved in the progression of diabetes and/or the development of complications may be apparent at the Pre-DM state or during the transition to diabetes. Hypomethylation of a number of genes related to kidney function may be an early marker for developing diabetic nephropathy. | Thomas A Vander Jagt Monica H Neugebauer Marilee Morgan Donald W Bowden Vallabh O Shah | 2015 | World Journal of Diabetes2015，6，9： | 5 |
| 2 | Wave propagation in a mulitilayered laminated cross-ply composite plate 显示文摘 | Karunasena W Shah A H Datta S K | 1991 | ASME J Appl Mec1991，58，： | 2 |
| 3 | Determining strong-motion duration of earthquakes 显示文摘 | MeCann M W Shah H C | 1979 | Bulletin of the Seismological Society of America1979，69，4： | 1 |
| 4 | Biochemical changes in wheat during storage at three temperatures显示文摘 | Rehman Z U Shah W H | 1999 | Plant Foods Human Nutr1999，54，2： | 1 |
| 5 | A generalized approach for the determination of yield stress by slump and slump flow显示文摘 | SAAK A W JENNINGS H M SHAH S P | 2004 | Cement and Concrete Research2004，34，3： | 1 |
| 6 | A generalized ap-proach for the determination of yield stress by slump andslump flow显示文摘 | Saak A W Jennings H M Shah S P | 2004 | Cement Concrete Research2004，34，3： | 1 |
| 7 | Vertex method for computing functions of fuzzy variables显示文摘 | Dong W Shah H C | 1987 | Fuzzy Sets and Systems1987，24，： | 1 |
| 8 | Wave propagation in a multilayered laminated cross-ply composite plate显示文摘 | Karunasena W Shah A H Datta S K | 1991 | Journal of Applied Mechanics1991，58，10： | 1 |
| 9 | Storage of wheat with ears显示文摘 | SHAH W H KAUSAR T HUSSAIN A | 2002 | Pakistan Journal of Agricultural Research2002，17，3： | 1 |
| 10 | Percutaneous vertebroplasty a technique to treat refractory spinal pain in the setting of advanced metastatic cancer: a case series 显示文摘 | Burton A W Reddy S K Shah H N | 2005 | J Pain Symptom Manage2005，30，1： | 1 |
| 11 | Subcellular localization and oligomerization of the A rabidopsis thaliana somatic embryogenesis receptor kinase 1 protein显示文摘 | Shah K Gadella T W van Erp H | 2001 | J Mol Biol2001，309，： | 1 |
| 12 | Rhabdomyolysis显示文摘 | Bagley W H Yang H Shah K H | | 0，，： | 1 |
| 13 | Epidermoid cyst ofthe testis:areport of three cases and aanalysis of 141 cases from the world literature显示文摘 | Shah K H Maxted W C Chun B | | 0，，： | 1 |
| 14 | New methodology for designing self-compacting concrete显示文摘 | SAAK A W JENNINGS H M SHAH S P | 2001 | ACI Materials Journal2001，98，6： | 1 |
| 15 | Proteolytic enzymes mediators of glomerular injury显示文摘 | Shah S V | 1991 | Kidney Int1991，40，： | 1 |
| 16 | Vertex method for computing functions of fuzzy variables显示文摘 | Dong W M Shah H C | 1987 | Fuzzy Sets and Systems1987，24，1： | 1 |
| 17 | Efficacy of 3, 5- dibromo- L- phenylalanine in ratmodels of stroke, seizures and sensorimotor gating deficit 显示文摘 | CAO W SHAH H P GLUSHAKOV A V | 2009 | Br J Pharmacol2009，158，： | 1 |
| 18 | Citric acid as a solid-state plasticizer for Eudragit RS PO 显示文摘 | Schilling S U Shah N H Malick A W | 2007 | Journal ofPharmacy and Pharmacology2007，59，： | 1 |
| 19 | The influence of wall slip on yield stress and viscoelastic measurements of cement paste显示文摘 | Saak A W Jennings H M Shah S P | 2001 | Cement and Concrete Research2001，31，1： | 1 |
| 20 | Femtosecond charge transport in polar semiconductors显示文摘 | A Leitenstorfer S Hunsche J Shah M C Nuss W H Knox | 1999 | 82:51401999，82，： | 1 |
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