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| 1 | Clostridium difficile infections in China显示文摘Clostridium difficile (C. difficile) infection has become one of the major hospital-associated infections in West-ern countries in the last two decades. However, there is limited information on the status of C. difficile infection inChinese healthcare settings. Given the large and increasing elderly population and the well-recognized problem ofover-prescribing of broad spectrum antibiotics in China, it is critical to understand the epidemiology and potentialrisk factors that may contribute to C. difficile infection in China. A literature review of available published studies,including those in Chinese language-based journals, was conducted. A review of the currently available literaturesuggested the presence of C. difficile infections in China, but also suggested that these infections were not particu-larly endemic. This finding should lead to better designed and greatly expanded studies to provide a more reliableepidemiologically-based conclusion on the actual status of C. difficile infection in China, including the identifica-tion of any associated risk factors. Such information is ultimately valuable to develop appropriate strategies to pre-vent C. difficile infection and the vast negative impact of such infections in China and other developing countries. | Ke Jin a,b,c,Shixia Wang c,d,Zuhu Huang a,b,c,Shan Lu b,c,daDepartment of Infectious Diseases,bJiangsu Province Key Laboratory in Infectious Diseases,cChina-US Vaccine ResearchCenter,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China d Department of Medicine,University of Massachusetts Medical School,Worcester,MA 01655,USA. | 2010 | The Journal of Biomedical Research2010，24，6： | 14 |
| 2 | A potential red-emitting phosphor Ca_(2)YTaO_(6):Eu^(3+):Luminescence properties,thermal stability and applications for white LEDs显示文摘A novel red-emitting phosphor tantalate Ca_(2)YTaO_(6):Eu^(3+)was synthesized by a solid-state reaction.The purity and surface morphology of the phosphors were characterized.The Ca_(2)YTaO_(6):Eu^(3+)phosphors show a sharp emission peak at 612 nm under near-ultraviolet(n-UV) at 395 nm because of the ^(5)D0→^(7)F_(2) transition of Eu^(3+).The optimal Eu^(3+)doping concentration in Ca_(2)YTaO_(6) is 40 mol% and the critical energy-transfer distance of Eu^(3+)ions was calculated to be 0.9 nm.The emission spectra of Ca_(2)YTaO_(6):Eu_(3+)from 300 to 480 K were investigated.The thermal-quenching temperature(T_(0.5)) of Ca_(2)YTaO_(6):Eu^(3+)is above 480 K.The color purity of Ca_(2)YTaO_(6):40 mol%Eu^(3+)is as high as 99.8%.The luminescence lifetime of Ca_(2)YTaO_(6):40 mol%Eu^(3+)was also discussed.The high color purity and high thermal stability of Eu^(3+)-doped Ca_(2)YTaO_(6) phosphors contribute to its application value in white lightemitting diodes(w-LEDs). | Ka Ding Siru A Shuo Pang Leyan Shan Yaqi Zhang Pengfei Sun Bin Deng Ruijin Yu | 2021 | Journal of Rare Earths2021，39，7： | 4 |
| 3 | 聚烯烃的创新及其在包装胶行业中的应用显示文摘聚烯烃胶粘剂在过去10年中已得到行业和市场认可,茂金属催化的聚烯烃(包括新一代后茂金属催化的聚烯烃)以其独特的性能优势和成本优势已成功应用于胶粘剂的诸多领域。通过与原料供应商和热熔胶生产商的合作,这项技术正为热熔胶应用和最终用户提供前所未有的更新更好的机会。陶氏化学作为聚烯烃行业的先驱和领导者,通过不断的技术创新推动产品开发,其产品系列(如AFFINITYTMGA聚烯烃弹性体、ENGAGETM聚烯烃弹性体、VERSIFYTM聚烯烃弹性体和INFUSETM聚烯烃嵌段聚合物等)可为热熔胶行业提供更有竞争力的解决方案。 | 陈理文 黄旭东 陈全 Yalvac S McLennaghan A Li Pi Shan C | 2012 | 中国胶粘剂2012，21，5： | 3 |
| 4 | Medical student depression and its correlates across three international medical schools显示文摘BACKGROUND Medical students have high rates of depression, anxiety, and burnout that have been found to affect their empathy, professional behaviors, and performance as a physician. While studies have examined predictors for burnout and depression in the United States (US), no study, to our knowledge, has compared depression in medical students cross-culturally, or has attempted to examine the effect of factors influencing rates including burnout, exercise, stress, unmet mental health needs, and region. AIM To examine rates of depression in three international cohorts of medical students, and determine variables that may explain these differences. METHODS Convenience samples of medical students from three countries (US, China, and a Middle Eastern country whose name remains anonymous per request from the school) were surveyed in this observational study. Using the Patient Health Questionnaire-2 (PHQ-2) and a modified Maslach Burnout Inventory, depression and burnout were examined among medical students from the three cohorts (n = 473). Chi-square test and analysis of variance were used to examine differences in demographics, behavioral, and psychological variables across these three schools to identify potentially confounding descriptive characteristics. Analysis of covariance compared depression and the emotional exhaustion component of burnout identified through Principal Component Analysis across countries. Multiple linear regression was used to analyze the impact of demographic, behavioral, and psychological variables on screening positive for depression. RESULTS Medical students from the Middle Eastern country had the highest rates of positive depression screens (41.1%), defined as a PHQ-2 score of ≥ 3, followed by China (14.1 %), and then the US (3.8%). More students in the Middle Eastern school had unmet mental health needs (50.8%) than at the medical school in China (34.8%) or the school in the US (32.8%)(Pearson chi-square significance < 0.05). Thus, PHQ-2 scores were adjusted for unmet mental health needs;however, the Middle Eastern country continued to have the highest depression. Adjusting for PHQ-2 score, medical students from the US scored the highest on emotional exhaustion (a measure of burnout). Demographic variables did not significantly predict medical student depression;however, lack of exercise, unmet mental health needs, stress, and emotional exhaustion predicted nearly half of depression in these cohorts. In comparison to the US, coming from the Middle Eastern country and China predicted higher levels of depression. CONCLUSION Depression rates differ in three international cohorts of medical students. Measured factors contributed to some observed differences. Identifying sitespecific prevention and intervention strategies in medical student mental health is warranted. | Jessica A Gold Xinran Hu Gan Huang Wan-Zhen Li Yi-Fan Wu Shan Gao Zhe-Ning Liu Mickey Trockel Wan-Zhen Li Yi-Fan Wu Shan Gao Zhe-Ning Liu Robert M Rohrbaugh Kirsten M Wilkins | 2019 | World Journal of Psychiatry2019，9，4： | 2 |
| 5 | Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric ligation-induced gastroduodenal ulcer in rats显示文摘BACKGROUND Sulongga-4(SL-4)is a herbal formula used in traditional Mongolian medical clinics for the treatment of peptic ulcers and gastroenteritis,even though its pharmacological mechanism has not been well characterized.AIM To evaluate the protective effect and identify the mechanisms of action of SL-4 on gastroduodenal ulcer induced by pyloric ligation(PL)in rats.METHODS PL was performed to induce gastric and duodenal ulcers in rats,which were then treated with oral SL-4(1.3,2.6,or 3.9 g/kg per day)for 15 d.PL-induced gastroduodenal ulceration.Therapeutic effects were characterized by pathological and histological evaluations and inflammatory indicators were analyzed by enzyme-linked immunosorbent assay.Microarray analyses were conducted to identify gene expression profiles of gastroduodenal tissue in PL rats with or without SL-4 treatment.The candidate target genes were selected and verified by quantitative reverse transcription polymerase chain reaction(qRT-PCR).RESULTS SL-4 decreased histopathological features in the PL-induced ulcerated rats.SL-4 significantly (P < 0.05) decreased expression of tumor necrosis factor-α,interleukin (IL)-1β, IL-6, endotoxin, platelet-activating factor, and increasedprostaglandin E2 and epidermal growth factor in ulcer tissue. Microarray analysiswas used to identify a panel of candidate target genes for SL-4 acting on PLinducedulceration. Genes included some complement and coagulation cascadeand retinol metabolism pathways that are closely associated with inflammatoryresponses and gastric mucosal protective mechanisms. qRT-PCR showed thataltered expression of the selected genes, such as CYP2b2, UGT2b1, A2m, andMASP1 was consistent with the microarray results.CONCLUSIONSL-4 exerts protective effects against PL-induced gastroduodenal ulcers viareducing inflammatory cytokines and elevating expression of gastric acidinhibitory factors. Downregulation of CYP2b2 and UGT2b1 genes in retinolmetabolism and upregulation of A2m and MASP1 genes in the complement andcoagulation cascades pathways are possibly involved in SL-4-mediated protectionagainst gastroduodenal ulcer. | Shan Tong Huan Wang Li-Sha A Ta-Na Bai Ju-Hua Gong Wen-Jie Jin Li-Li Dai Gen-Na Ba Sung-Bo Cho Ming-Hai Fu | 2021 | World Journal of Gastroenterology2021，27，16： | 2 |
| 6 | Discovering rules for water demand prediction:an enhanced rough _ set approach显示文摘 | Shan N Chan C | 1996 | Engineering applications in artificial intelligence1996，9，6： | 1 |
| 7 | Enhancement of doxorubicin and vinblasrine sensitivity in anthracycline resistant p388 cells 显示文摘 | Ramu A Shan T Glanbiger D | 1983 | Cancer Treat Rep1983，67，： | 1 |
| 8 | Ultrahigh stress and strain in hierarchically structured hollow nanoparticles显示文摘 | SHAN Z ADESSO G CABOT A etal | 2008 | Nature Materials2008，7，18： | 1 |
| 9 | Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding proteinlc (SREBP-lc) gene by antagonizing ligand-dependent activation of the LXR显示文摘 | Ou J Tu H Shan B Luk A DeBose-Boyd RA Bashmakov Y Goldstein JL Brown MS | | 0，，11： | 1 |
| 10 | Membrane interaction of bound ligands contributes to the negative binding cooperativity of the EGF receptor显示文摘 | Arkhipov A Shan Y Kim ET | 2014 | PLoS Comput Biol2014，10，10： | 1 |
| 11 | Anthracycline-induced cardiotoxicity显示文摘 | SHAN K LINCOFF A YOUNG J | 1996 | Ann Int Med1996，125，： | 1 |
| 12 | Fusion expression of bovine lactoferricin in Escherichia coli 显示文摘 | Feng X Wang J Shan A | 2006 | Protein Expression and Purification2006，47，1： | 1 |
| 13 | Discovering rules for water demand prediction: An enhanced rough-set approach显示文摘 | An A Shan N Chan C | 1996 | Engineering Application and Artificial Intelligence1996，9，6： | 1 |
| 14 | Effect of dietary phytate on growth andselenium status of chicks fed selenite or selenomethionine 显示文摘 | Shan Davis A S R H | 1994 | British Poultry Science1994，35，： | 1 |
| 15 | High-quality motion deblurringfrom a single image显示文摘 | Shan Q Jia J Agarwala A | 2008 | ACM Transactions on Graph2008，27，3： | 1 |
| 16 | Novel design of short antimicrobial peptides derived from the bacteri- cidal domain of avian β-defensin-4 显示文摘 | DONG N MA Q Q SHAN A S | 2012 | Protein and Peptide Letters2012，19，11： | 1 |
| 17 | Expression in Pichia pastoris and biological activity of avian beta defensin 6 and its mutant peptide without cysteines显示文摘 | CAO Y MA Q SHAN A | 2012 | Protein Peptide Lett2012，19，10： | 1 |
| 18 | 显示文摘 | Shan A Y Ghazi T I M Rashid S A | 2010 | Appl Catal a Gen2010，389，12： | 1 |
| 19 | Direct observation of shear deformation during equal channel angular pressing of pure aluminum显示文摘 | Shan A Moon I Park J | 1999 | Scripta Materialia1999，41，： | 1 |
| 20 | Contact mechanics and lubrication hydrodynamics of chemical mechanical polishing显示文摘 | J Tichy J A Levert L Shan | 1999 | J of the Electrochemical Society1999，146，4： | 1 |
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