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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | The dependences of osteocyte network on bone compartment, age, and disease显示文摘Osteocytes, the most abundant bone cells, form an interconnected network in the lacunar-canalicular pore system(LCS) buried within the mineralized matrix, which allows osteocytes to obtain nutrients from the blood supply, sense external mechanical signals, and communicate among themselves and with other cells on bone surfaces. In this study, we examined key features of the LCS network including the topological parameter and the detailed structure of individual connections and their variations in cortical and cancellous compartments, at different ages, and in two disease conditions with altered mechanosensing(perlecan deficiency and diabetes).LCS network showed both topological stability, in terms of conservation of connectivity among osteocyte lacunae(similar to the ‘‘nodes' ' in a computer network), and considerable variability the pericellular annular fluid gap surrounding lacunae and canaliculi(similar to the ‘‘bandwidth'' of individual links in a computer network). Age, in the range of our study(15–32 weeks), affected only the pericellular fluid annulus in cortical bone but not in cancellous bone. Diabetes impacted the spacing of the lacunae, while the perlecan deficiency had a profound influence on the pericellular fluid annulus. The LCS network features play important roles in osteocyte signaling and regulation of bone growth and adaptation. | Xiaohan Lai Christopher Price Shannon Modla William R Thompson Jeffrey Caplan Catherine B Kirn-Safran Liyun Wang | 2015 | Bone Research2015，3，2： | 6 |
| 3 | Acute liver failure due to natural killer-like T-cell leukemia/ lymphoma: A case report and review of the Literature显示文摘尖锐的肝失败(ALF ) 是为肝移植要求立即的评估的一种医药紧急情况。我们描述与腹水,黄疸,和脑病介绍了并且被发现由于象 T 房间白血病 / 淋巴瘤一样的生来的杀手(NK ) 有 ALF 的一个病人的一个不平常的盒子。关键免疫显型是 CD2+ , CD3+ , CD7+ , CD56+ 。这诊断,在外部血和腹水基于调查结果,与肝活体检视被证实,并且是到肝移植的禁止徵候。hematologic 恶意是暴发性的肝的失败的一个不平常的原因的文学表演的评论,和那个象 NK 一样 T 房间白血病 / 淋巴瘤是一最近相对表示特性地认出了是的实体 CD3+ 和 CD56+ 。这个盒子证明那肝活体检视在与淋巴瘤 / 白血病能引起尖锐的肝失败的象 NK 一样 T 房间诊断肝的尖锐的肝失败,和那渗入的不平常的原因是必要的。 | Evan S Dellon Shannon R Morris Wozhan Tang Cherie H Dunphy Mark W Russo | 2006 | World Journal of Gastroenterology2006，12，25： | 5 |
| 4 | Reasons fornon randomization in the UK3 trial of surgical app roach in localizedWilms' tumour requiting a difficult day one randomization:a UKCCSGWilms' Tumour Group study显示文摘 | Pritchard-Jones K Mitchell C Shannon R | 2003 | Med Pediatr Oncol2003，41，： | 1 |
| 5 | 显示文摘 | Shannon R D | 1976 | Acta Crystallogr Sect A1976，32，： | 1 |
| 6 | Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides显示文摘 | Shannon R D | 1976 | Acta Cryst1976，32，： | 1 |
| 7 | Infant methaemoglobinaemia:The role of dietary nitrate显示文摘 | Greer F R Shannon M | 2005 | Pediatrics2005，116，3： | 1 |
| 8 | The treatment ofWilms'tumo-ur:the United Kingdom Children 's Cancer Study GroupthirdWilms' tumour study显示文摘 | Mitchell C Shannon R Vujanic | 2003 | Med Pediatr Oncol2003，41，： | 1 |
| 9 | 显示文摘 | Shannon R D | 1993 | J Appl Phys1993，73，： | 1 |
| 10 | Revised ejective ionic radii and systematic studies of interatomic distance in halides and chalcogenides 显示文摘 | SHANNON R D | 1976 | Actacrystallogr A1976，32，： | 1 |
| 11 | Revised ejective ionic radii and systematic studies of interatomic distance in halides and chalcogenides显示文摘 | SHANNON R D | 1976 | Acta Crystallogr A1976，32，1： | 1 |
| 12 | Regulation of milk protein gene expression显示文摘 | Jeffrey M R Shannon L W Darryl H | 1999 | Annu Rev Nutr1999，19，： | 1 |
| 13 | Ultra- sound velocity measurement to determine lipid content in salmon muscle :the effects of myosepta显示文摘 | SHANNON R A PROBERT - SMITH P J LINES J | 2004 | Food Research International2004，37，： | 1 |
| 14 | Revised effective ionic radii and systematic studies of interatomie distances in halides and chalcogenides 显示文摘 | SHANNON R | 1976 | Acta Crystallographica Section A1976，32，5： | 1 |
| 15 | Revised Effective Ionic Radii and Systematic Studies of Interatomic Distances in Ha/ides and Chaleogenides 显示文摘 | Shannon R D | 1976 | Acta Crystallographic Section A : Foundations1976，32，： | 1 |
| 16 | 查看详情显示文摘 | Shannon R D | | 0，，5： | 1 |
| 17 | Prenatal care in the Paso del Norte border region 显示文摘 | Fullerton JT Nelson C Shannon R Bader J | 2004 | Perinatol2004，24，2： | 1 |
| 18 | Regulation of Retinal Cone Bipolar Cell Differentiation and Photopic Vision by the CVC Homeobox Gene Vsx1显示文摘 | Akihira Ohtoshi Steven W Wang Hidetaka Maeda Shannon M Saszik Laura J Frishman William H Klein Richard R Behringer | 2004 | Current Biology2004，，6： | 1 |
| 19 | An innovative enterostomal thera py nurse model of community wound care delivery:a ret rospective cost-effectiveness analysis显示文摘 | Harris C Shannon R | 2008 | J Wound Osto my Continence Nuts2008，35，2： | 1 |
| 20 | Giant Aneurysms of Coronary Arteries and Saphenous Vein Grafts: Angiographic Findings and Histopathological Correlates显示文摘 | Topaz O Molly S R Shannon M B etal | 2005 | Cardiovascular Pathology2005，14，6： | 1 |
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