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| 1 | Analysis of Factors Associated with Death in Maintenance Hemodialysis Patients: A Multicenter Study in China显示文摘 | Kang-Kang Song De-Long Zhao Yuan-Da Wang Yong Wang Xue-Feng Sun Li-Ning Miao Zhao-Hui Ni Hong-Li Lin Fu-You Liu Ying Li Ya-Ni He Nian-Song Wang Cai-Li Wang Ai-Hua Zhang Meng-Hua Chen Xiao-Ping Yang Yue-Yi Deng Feng-Min Shao Shu-Xia Fu Jing-Ai Fang Guang-Yan Cai Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，8： | 39 |
| 2 | Prevalence and evolution of drug resistance HIV-1 variants in Henan, China显示文摘To understand the prevalence and evolution of drug resistant HIV strains in Henan China after the implementation of free antiretroviral therapy for AIDS patients. 45 drug nave AIDS patients, 118 AIDS patients who received three months antiretroviral therapy and 124 AIDS patients who received six months antiretroviral treatment were recruited in the southern part of Henan province. Information on general condition, antiretroviral medicines, adherence and clinical syndromes were collected by face to face interview. Meanwhile, 14ml EDTA anticoagulant blood was drawn. CD4/CD8 T cell count, viral load and genotypic drug resistance were tested. The rates of clinical improvement were 55.1% and 50.8% respectively three months and six months after antiretroviral therapy. The mean CD4 cell count after antiretroviral therapy was significantly higher than in drug nave patients. The prevalence rate of drug resistant HIV strains were 13. 9%, 45.4% and 62.7% in drug nave patients, three month treatment patients and six month treatment patients, respectively. The number of resistance mutation codons and the frequency of mutations increased significantly with continued antiretroviral therapy. The mutation sites were primarily at the 103, 106 and 215 codons in the three-month treatment group and they increased to 15 codon mutations in the six-month treatment group. From this result, the evolution of drug resistant strains was inferred to begin with the high level NNRTI resistant strain, and then develop low level resistant strains to NRTIs. The HIV strains with high level resistance to NVP and low level resistance to AZT and DDI were highly prevalent because of the AZT+DDI+NVP combination therapy. These HIV strains were also cross resistant to DLV, EFV, DDC and D4T. Poor adherence to therapy was believed to be the main reason for the emergence and prevalence of drug resistant HIV strains. The prevalence of drug resistant HIV strains was increased with the continu- ation of antiretroviral therapy in the southern part of Henan province. Measures, that could promote high level adherence, provide new drugs and change ART regimens in failing patients, should be implemented as soon as possible. | Jing Yun LI Han Ping LI Lin LI Hong LI Zhe WANG Kun YANG Zuo Yi BAO Dao Min ZHUANG Si Yang LIU Yong Jian LIU Hui XING Yi Ming SHAO | 2005 | Cell Research2005，15，11： | 34 |
| 3 | A comprehensive review of Energy Internet: basic concept,operation and planning methods, and research prospects显示文摘With the intensifying energy crisis and environmental pollution, the Energy Internet and corresponding patterns of energy use have been attracting more and more attention. In this paper, the basic concept and characteristics of the Energy Internet are summarized, and its basic structural framework is analyzed in detail. On this basis,couplings between the electric power system and other systems such as the cooling and heating system, the natural gas system, and the traffic system are analyzed, and the operation and planning of integrated energy systems in both deterministic and uncertain environments are comprehensively reviewed. Finally, the research prospects and main technical challenges of the Energy Internet are discussed. | Yijia CAO Qiang LI Yi TAN Yong LI Yuanyang CHEN Xia SHAO Yao ZOU | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，3： | 25 |
| 4 | Distribution characteristic and geological signiflcance of rare earth elements in Lopingian mudstone of Permian,Panxian county,Guizhou province显示文摘In order to discuss the geochemical characteristic of REEs(rare earth elements) and their geological application,we measured the contents of rare earth elements,trace elements and minerals of 29 Lopingian(Late Permian) mudstone samples in Panxian county,carrying out ICP-MS and XRD analysis.The results show that the amount of REEs(185.56-729.46 10à6) is high.The ratios of w(LREE)/w(HREE)(6.84-13.86) and w(La)N/w(Yb)N(1.01-3.02) show clear differentiation of LREEs and HREEs.RREE has a significantly or critically positive correlation with lithophile elements Th,Nb,Ta,Ti,Ga,Sc,Cs,Zr,Hf,Sr,Be and chalcophile element Zn,a critically negative correlation with siderophile element Fe and a slightly positive correlation with illite,illite smectite mixed layers and siderite.REEs originate mainly from terrigenous minerals,in an inorganic phase.Source rocks of our samples consist of Emeishan basalt and a small part of sedimentary rocks,as suggested by the distribution patterns of REEs and w(PREE)-w(La)/w(Yb) diagram.Moreover,abnormal surfaces near the sequence boundaries(SB2,SB3,SB4) are related with the boundaries,identifled by geochemical characteristics of the REEs,such as PREE,w(LREE)/w(HREE),Eu/Eu and Ceanom. | Shao Yubao Guo Yinghai Qin Yong Shen Yulin Tian Li | 2011 | Mining Science and Technology2011，21，4： | 23 |
| 5 | Breast non-mass-like lesions on contrast-enhanced ultrasonography: Feature analysis, breast image reporting and data system classification assessment显示文摘BACKGROUND Breast non-mass-like lesions(NMLs)account for 9.2%of all breast lesions.The specificity of the ultrasound diagnosis of NMLs is low,and it cannot be objectively classified according to the 5th Edition of the Breast Imaging Reporting and Data System(BI-RADS).Contrast-enhanced ultrasound(CEUS)can help to differentiate and classify breast lesions but there are few studies on NMLs alone.AIM To analyze the features of benign and malignant breast NMLs in grayscale ultrasonography(US),color Doppler flow imaging(CDFI)and CEUS,and to explore the efficacy of the combined diagnosis of NMLs and the effect of CEUS on the BI-RADS classification of NMLs.METHODS A total of 51 breast NMLs verified by pathology were analyzed in our hospital from January 2017 to April 2019.All lesions were examined by US,CDFI and CEUS,and their features from those examinations were analyzed.With pathology as the gold standard,binary logic regression was used to analyze the independent risk factors for malignant breast NMLs,and a regression equation was established to calculate the efficiency of combined diagnosis.Based on the regression equation,the combined diagnostic efficiency of US combined with CEUS(US+CEUS)was determined.The initial BI-RADS-US classification of NMLs was adjusted according to the independent risk factors identified by CEUS,and the diagnostic efficiency of CEUS combined with BI-RADS(CEUS+BI-RADS)was calculated based on the results.ROC curves were drawn to compare the diagnostic values of the three methods,including US,US+CEUS,and CEUS+BI-RADS,for benign and malignant NMLs.RESULTS Microcalcification,enhancement time,enhancement intensity,lesion scope,and peripheral blood vessels were significantly different between benign and malignant NMLs.Among these features,microcalcification,higher enhancement,and lesion scope were identified as independent risk factors for malignant breast NMLs.When US,US+CEUS,and CEUS+BI-RADS were used to identify the benign and malignant breast NMLs,their sensitivity rates were 82.6%,91.3%,and 87.0%,respectively;their specificity rates were 71.4%,89.2%,and 92.9%,respectively;their positive predictive values were 70.4%,87.5%,and 90.9%,respectively;their negative predictive values were 83.3%,92.6%,and 89.7%,respectively;their accuracy rates were 76.5%,90.2%,and 90.2%,respectively;and their corresponding areas under ROC curves were 0.752,0.877 and 0.903,respectively.Z tests showed that the area under the ROC curve of US was statistically smaller than that of US+CEUS and CEUS+BI-RADS,and there was no statistical difference between US+CEUS and CEUS+BI-RADS.CONCLUSION US combined with CEUS can improve diagnostic efficiency for NMLs.The adjustment of the BI-RADS classification according to the features of contrastenhanced US of NMLs enables the diagnostic results to be simple and intuitive,facilitates the management of NMLs,and effectively reduces the incidence of unnecessary biopsy. | Ping Xu Min Yang Yong Liu Yan-Ping Li Hong Zhang Guang-Rui Shao | 2020 | World Journal of Clinical Cases2020，8，4： | 18 |
| 6 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 7 | Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China显示文摘This prospective study was designed to examine the combined influence of insulin resistance(IR)and inflammatory biomarker levels on type 2 diabetes mellitus(T2DM)among 1,903Inner Mongolians.During follow-up,205(10.77%)participants developed T2DM,and the incidence | QIU Qiao Yan ZHANG Bei Lei ZHANG Ming Zhi WU Jia Hui ZHOU Jing Wen LIANG Zhu ZHANG Yong Hong ZHANG Shao Yan | 2018 | Biomedical and Environmental Sciences2018，31，4： | 15 |
| 8 | Immunotherapy using IL-2 and GM-CSF is a potential treatment for multidrug-resistant Mycobacterium tuberculosis显示文摘This study investigated the therapeutic effects of interleukin (IL)-2 and granulocyte-macrophage colony-stimulating factor (GM-CSF) coadministrated with antibacterial agents isoniazid (INH) and rifampin (RIF) to treat a mouse model of tuberculosis (TB) infection. A drug-susceptible TB strain, H37Rv was used to infect mice and the effectiveness of IL-2 and GM-CSF was initially evaluated based on survival rate, bacterial counts in lungs and spleens and the pathological condition of the lungs. Next, the therapeutic effect of the immunotherapy regimen was assessed in multidrug-resistant strain OB35-infected mice. In the H37Rv infection model, IL-2 and GM-CSF monotherapies reduced bacterial numbers in the lungs by 0.82 (P<0.01) and 0.58 (P<0.05) lg colony-forming units (CFU), respectively, and in the spleens by 1.42 (P<0.01) and 1.22 (P<0.01) lg CFU, respectively, compared with the untreated group. Mice receiving immunotherapy developed fewer lesions in the lungs compared with mice receiving antibacterial therapy alone. In the OB35 infection model, immunotherapy with either cytokine resulted in a significant reduction of bacterial load in the lungs and spleens and less severe lesions in the lungs compared with the untreated or antibacterial therapy treated mice. Notably, mice receiving immunotherapy with both cytokines had a 30% survival rate which was higher than that in other treated groups, and had significantly less CFUs in the lungs and spleens (1.02 and 1.34 lg CFU) compared with antibacterial therapy alone (P<0.01). This study demonstrated that immunotherapy with both IL-2 and GM-CSF may be useful to treat multidrug resistant tuberculosis (MDR-TB). | ZHANG YongRong LIU Jian WANG Yong XIAN Qiaoyang SHAO LingYun YANG Zhong WANG XiaoNing | 2012 | Science China(Life Sciences)2012，55，9： | 15 |
| 9 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 10 | Function and regulation of cholecystokinin-octapeptide, β-endorphin and gastrin in anorexic infantile rats treated with ErBao Granules显示文摘AIM To study the role of cholecystokinin octapeptide ( CCK-8), β-endorphin ( β-EP), and gastrin in an anorexic infantile rat model and no subsequent regulation of nose peptides by the Yunpi complex prescription ErBao Granule.METHODS We fed infantile rats with special prepared forage. A liquid extract of ErBao Granule was administered to the rats daily for 3weeks, CCK-8, β-EP, and gastrin concentrations in hypothalamus, gastric antrum, and plasma of the rats were measured by radioimmunoassay,and were compared with controls.RESULTS Treatment of rats with ErBao Granule inhibited CCK-8 secretion and increased β-EP and gastrin secretion. CCK-8 concentration in hypothalamus and plasma of model control group increased significantly and correlated negatively with food intake of models.respectively. β-EP concentration in gastric antrum and plasma of model control group decreased significantly and showed a positive correlation with food intake of models,respectively. Hypothalamus concentration of β-EP was similar in models and controls. Gastrin concentration in gastric antrum of models was lower than in the blank control group, and correlated positively to food intake of models.Finally, CCK-8 concentrations in plasma of rats showed a positive correlation with plasma β-EP(r- 0.68, P<0.05).CONCLUSION The increased plasma and hypothalamus concentration of CCK-8,decreased gastric antrum and plasma level of β-EP. and decreased gastric antrum concentration of gastrin are associated significantly with the anorexia of infantile anorexic rat models produced by special forage. ErBao Granule can reverse these changes, which may be the major mechanisms of ErBao Granule simulating feeding. | Yong Ping Du1 Yue Ping Zhang2 Shou Chuan Wang3 Jian Shi1 Shao Hua Wu1,1.Department of Traditional Chinese Medicine. Xijing Hospital, theFourth Military Medical University. Xi an 7101132, Shaanxi Province,China 2.Department of Pediatrics. Xijing Hospital, the Fourth Military MedicalUniversity. Xi’an 710032. Shaanxi Province. China 3.Department of Pediatrics. Nanjing University of Traditional ChineseMedicine, Nanjing71011?l, Jiangsu Province. China | 2001 | World Journal of Gastroenterology2001，7，2： | 14 |
| 11 | Preliminary study on the production of transgenic mice harboring hepatitis B virus X gene显示文摘INTRODUCTIONDespiteoverwhelmingepidemiologicalevidencelinkingpersistentHepatitisBVirus(HBV)infectionandthedevelopmentofhepato... | ZHU Huan Zhang 1, CHENG Guo Xiang 2, CHEN Jian Qu 2, KUANG Shu Yuan 3, CHENG Yong 2, ZHANG Xin Li 1, Ll Hou Da 2, XU Shao Fu 2, SHI Jing Quan 1, QIAN Geng Sun 3 and GU Jian Ren 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 14 |
| 12 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 13 | Short-Impending Earthquake Anomaly Index Extraction of GNSS Continuous Observation Data in Yunnan,Southwestern China显示文摘This paper presents a comprehensive area expansion prediction index method to apply GNSS for short-impending prediction of earthquakes. Based on continuous GNSS observation data from Yunnan Province, a displacement field was detected after data cycle-slip repair using precision data processing software and geophysical field effect model correction. The Yunnan area was divided into 56 grid cells for displacement field interpolation to obtain a more uniform displacement field and a strain field variation time series. The pre-earthquake response of each grid-cell expansion time series was evaluated and synthesized to extract a short-impending earthquake anomaly identification index. The results show that this index indicated occurrence times and hypocenter for earthquakes of magnitude M≥5. Fourteen earthquakes were predicted accurately, and there were five false reports. This index can therefore be used for the short-impending prediction of earthquakes. | Min Hong Desheng Shao Tengfei Wu Shuangxi Zhang Yong Zhang Lingli Wang Xiaodong Qian | 2018 | Journal of Earth Science2018，29，1： | 13 |
| 14 | Antiinflammatory and immunoregulatory effects of total glucosides of Yupingfeng powder显示文摘背景 Yupingfeng,一张繁体中文建筑群药方,为与象过敏鼻炎和长期的支气管炎那样的免疫不全有关的煽动性的疾病的痊愈和预防在中国有效地被使用了。然而,这张药方的活跃部件仍然保持不清楚。现在的学习集中了于从 Yupingfeng 调查 glucosidic 摘录的 antiinflammatory 和 immunoregulatory 效果。我们为耳朵胀大测试了动物模型的方法在老鼠由 dimethylbenzene 导致了;手掌胀大由棉花小团在老鼠导致的 carregeenin 和 granuloma 导致了;在 immunosuppressed 老鼠的怒气的 haemolysin,由脾的房间的抗体产生,推迟的超敏性和 T 房间子集的水平。显著地禁止的老鼠胀大的耳朵由 dimethylbenzene 导致了的 24 mg/kg, 48 mg/kg 和 96 mg/kg 的结果 Glucosidic 摘录。同样,禁止的老鼠胀大的手掌由 carregeenin 和 grenuloma 导致了的 16 mg/kg, 32 mg/kg 和 64 mg/kg 的 glucosidic 摘录由棉花小团导致了。24 mg/kg, 48 mg/kg 和 96 mg/kg 的 Glucosidic 摘录由 cyclophosphamide 在老鼠 immunosuppressed 在 splenocytes 在 haemolysin 的浆液和水平改进了 IgM 水平。在 cyclophosphamide 压制的老鼠的推迟的超敏性被 24 mg/kg, 48 mg/kg 和 96 mg/kg 的 glucosidic 摘录提高。这些结果建议 Yupingfeng 能与免疫力的抑制在老鼠恢复体液、细胞的有免疫力的功能。48 mg/kg 和 96 mg/kg 的 Glucosidic 摘录显著地抵抗了胀大的抑制免疫力的老鼠耳朵并且在将近正常的水平维持了它。glucosidic 的提高的、推迟的超敏性行动提取,由 cyclophosphamide 压制了,可能被导致 TH 房间并且调整 T 淋巴细胞引起子集。从 Yupingfeng 的 glucosidic 摘录有 antiinflammatory 和 immunoregulation 行动的结论,建议这些配糖物是繁体中文药方 Yupingfeng 的主要活跃部件。 | GAO Jian LI Jun SHAO Xu JIN Yong LV Xiong-wen GE Jin-fang HUANG Yan ZHANG Lei CHEN Lin | 2009 | Chinese Medical Journal2009，，14： | 12 |
| 15 | Failed anterior cruciate ligament reconstruction: analysis of factors leading to instability after primary surgery显示文摘 | MA Yong AO Ying-fang YU Jia-kuo DAI Ling-hui SHAO Zhen-xing | 2013 | Chinese Medical Journal2013，，2： | 11 |
| 16 | Characteristics and sedimentary processes of lamina-controlled sand-particle imbricate structure in deposits on Lingshan Island, Qingdao, China显示文摘Imbricate structure is a common sedimentary structure and is well developed in sandy sediments.Here,we report a laminacontrolled fine-sand-particle imbricate structure in a set of very fine grained sedimentary rocks(fine sandstone,siltstone,and mudstone)at the Dockyard and Qianceng Cliff areas of Lingshan Island,Qingdao,Shandong,China.Sets of up to 300 laminae are found in stratigraphic profiles in these areas.The laminae are generally less than 1 mm thick,with most being 0.3–0.4 mm thick and the thinnest being<0.1 mm.The dip angle of the imbricate structure varies widely,between 0°and 90°,with an average dip angle of about 40°–50°,which is higher than that of imbricate riverbed gravels(about 34°).The dip angle is a function of the shape and sorting of the particles,as well as the hydrodynamic conditions under which these fine-grained sediments were deposited.Several profiles show well-developed multiscale,soft-sediment deformation structures.Flute casts,load casts,and groove casts are also common.Fragments of carbon remains occur widely and commonly constitute stringers several millimeters thick and up to 10 cm long,together with fine clasts.Vitrain lenticles are also common.Based on the imbricate structure of the Lingshan Island deposits,it is shown that in addition to paleocurrent analysis,the imbricate structure can be used to infer information about fluid properties,transport characteristics,and sedimentary processes of the depositional environment.A near-bottom underflow,either of authigenic origin or derived from cold river water in winter in a delta interdistributary bay or delta-front environment,is inferred to have provided the hydrodynamic setting in which this imbricate structure formed.The imbricate structure,together with other sedimentary structures and features,shows that the sedimentary rocks on Lingshan Island were deposited in an inland,shallow-water environment,such as a delta,and not in a deep-water or submarine continental-slope environment. | SHAO ZhuFu ZHONG JianHua LI Yong MAO Cui LIU ShengXin NI LiangTian TIAN Yuan CUI XinYing LIU YunTian WANG XiaoNan LI WeiHua LIN GangShan | 2014 | Science China Earth Sciences2014，57，5： | 11 |
| 17 | Adefovir Dipivoxil plus Chinese Medicine in HBeAg-Positive Chronic Hepatitis B Patients:A Randomized Controlled 48-Week Trial显示文摘Objective:To evaluate the effects of a 48-week course of adefovir dipivoxil(ADV)plus Chinese medicine(CM)therapy,namely Tiaogan Jianpi Hexue(调肝健脾和血)and Tiaogan Jiedu Huashi(调肝解毒化湿)fomulae,in hepatitis B e antigen(HBeAg)-positive Chinese patients.Methods:A total of 605 HBeAg-positive Chinese CHB patients were screened and 590 eligible participants were randomly assigned to 2 groups in 1:1 ratio including experimental group(EG,received ADV plus CM)and control group(CG,received ADV plus CM-placebo)for 48 weeks.The major study outcomes were the rates of HBeAg and HBV-DNA loss on week 12,24,36,48,respectively.Secondary endpoints including liver functions(enzymes and bilirubin readings)were evaluated every 4 weeks at the beginning of week 24,36,and 48.Routine blood,urine,and stool analyses in addition to electrocardiogram and abdominal B scan were monitored as safety evaluations.Adverse events(AEs)were documented.Results:The combination therapy demonstrated superior HBeAg loss at 48 weeks,without additional AEs.The full analysis population was 560 and 280 in each group.In the EG,population achieved HBeAg loss on week 12,24,36,and 48 were 25(8.90%),34(12.14%),52(18.57%),and 83(29.64%),respectively;the equivalent numbers in the CG were 20(7.14%),41(14.64%),54(19.29%),and 50(17.86%),respectively.There was a statistically significant difference between two groups on week 48(P<0.01).No additional AEs were found in EG.Subgroup analysis suggested different outcomes among treatment patterns.Conclusion:Combination of CM and ADV therapy demonstrated superior HBeAg clearance compared with ADV monotherapy.The finding indicates that this combination therapy may provide an improved therapeutic effect and safety profile(ChiCTR-TRC-11001263). | LI Xiao-ke ZHANG Ming-xiang SHAO Feng-zhen ZHOU Da-qiao XUE Jing-dong LIU Tie-jun CHI Xiao-ling LU Bing-jiu WANG Xian-bo LI Qin LI Jun MAO De-wen YANG Hua-sheng YANG Hong-zhi ZHAO Wen-xia LI Yong ZHANG Guo-liang ZHAO Yi-ming ZOU Jian-dong LIU Meng-yang ZHANG Ke-ke YANG Xian-zhao GAN Da-nan LI Ying ZHANG Peng LI Zhi-guo LI Shuo YE Yong-an | 2020 | Chinese Journal of Integrative Medicine2020，26，5： | 9 |
| 18 | Enhancement of DNA vaccine-induced immune responses by a 72-bp element from SV40 enhancer显示文摘背景尽管 DNA 疫苗被看作疫苗的下一代,尽管有管理的 plasmid DNA 的增加的剂量,大多数 DNA 疫苗的候选人仍然正在受不了相对弱的 immunogenicity。为了提高免疫者, 优化codon 的 HIV 得到的回答作呕表示一样的基因的有复制 Tiantan 牛痘( RTV )的 DNA 疫苗,修改 plasmid 向量 pDRVI1.0 和增强软件免疫紧张是 employed.Methods 向量 pDRVI1.0 通过从 SV40 enhancer 插入 72-bp 元素被构造,它被报导支持 plasmid DNA 的原子运输,到 plasmid 向量 pVR1012 的 cytomegalovirus enhancer/promoter 区域在上游。从表示 plasmids 的基因表示层次基于 pDRVI1.0 和 pVR1012 被测试。独自一个的 DNA 疫苗或 DNA prime-RTV 增加政体导致的体液、细胞的有免疫力的回答在 72-bp 元素显著地在 DNA 种痘导致的非划分的cells.gag特定的体液、细胞的有免疫力的回答提高了基因表示水平,这被显示出的 mice.Results 被决定两个显著地被改进,当 Th1/Th2 平衡没被 72-bp 元素显然影响时。进一步显著地增加的 RTV 提高了 DNA 在偏导 Th1 的 manner.Conclusions 的告知疫苗的抗体和 T 房间回答 72-bp SV40 enhancer 元素应该在 DNA 疫苗的向量被包括, RTV 紧张是为增加免疫的很有效的实时向量。 | LI Hai-shan LIU Yong LI Ding-feng ZHANG Ran-ran TANG Hai-li ZHANG Yu-wei HUANG Wei LIU Ying PENG Hong XU Jian-qing HONG Kun-xue SHAO Yi-ming | 2007 | Chinese Medical Journal2007，，6： | 9 |
| 19 | Change of the cell cycle after flutamide treatment in prostate cancer cells and its molecular mechanism显示文摘瞄准:在房间的表示上探索雄激素受体(AR ) 的效果周期相关的基因例如 CDKN1A 和 BTG1,在前列腺癌症房间衬里 LNCaP。方法:在 AR 对手 flutamide 治疗和它由阶段对比显微镜和流动血细胞计数的效果的证实以后,房间的微分表示周期相关的基因被 cDNA 分析微数组。对待的房间作为控制作为试验性的组和 LNCaP 房间被设置的 flutamide。分别地,我们通过反向的抄写用 Cy5 和 Cy3 染料标记试验性的组和控制组的 cDNA 探针。然后我们 cDNA 与 cDNA 探查的 hybridized 微数组,它包含了 8 126 个唯一的人的 cDNA 序列和芯片被扫描在每个点上得到 Cy5 和 Cy3 的荧光灯的值。在主要分析以后,反向的抄写聚合酶链反应(RT-PCR ) 测试被执行证实薄片的结果。结果:在 AR 对手 flutamide 治疗以后, 326 基因(3.93%) 表示了差别, 97 下面调整并且 219 起来调整。在他们之中,八起来调整的基因可能是房间周期相关,也就是 CDC10, NRAS, BTG1, Wee1, CLK3, DKFZP564A122, CDKN1A 和 BTG2。CDKN1A 和 BTG1 基因 mRNA 表示被证实在由 RT-PCR 的试验性的组更高,当 p53 mRNA 表示没有重要变化时。结论:在前列腺癌症房间的 Flutamide 治疗力量起来调整 CDKN1A 和 BTG1 表示。CDKN1A 和 BTG1 的蛋白质表情在禁止癌症房间的增长起一个重要作用。CDKN1A 让一个伟人影响前列腺癌症房间的房间周期并且可以在一条 p53 独立的小径在癌症房间起一个作用。前列腺癌症房间可能影响由激活 AR 和 thus 的周期相关的基因打破的房间房间周期控制。 | Yong Wang Chen Shao Chang-Hong Shi Lei Zhang Hong-Hong Yue Peng-Fei Wang Bo Yang Yun-Tao Zhang Fan Liu Wei-Jun Qin He Wang Guo-Xing Shao | 2005 | Asian Journal of Andrology2005，7，4： | 9 |
| 20 | Facile synthesis and characterization of novel pseudo-hypercrosslinked resin显示文摘一种 pseudo-hypercrosslinked 聚合物树脂第一经由连续 Friedel 被综合苯, diphenyl 和他们的 dichloromethyl 的手艺完化聚合衍生物。并且这些树脂的微形态学和吸附性质被调查。结果证明新奇树脂有高度特定的表面积(581.26 974.88 m2/g ) ,高毛孔的体积(0.56 1.65 mL/g ) ,小平均多孔的半径(1.93 3.67 nm ) 和为小非极的器官的分子的优秀吸附性质。 | Si Guo Yuan Shao Hui Zhang Wei Hua Zou Yong Hao Zhou Xiao Hui Zhou | 2008 | Chinese Chemical Letters2008，19，5： | 9 |
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