|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 具有低动脉粥样硬化风险特征的专业耐力运动员的亚临床冠状动脉疾病发病率显示文摘研究表明,具有冠状动脉疾病(coronary artery disease,CAD)危险因素的中老年(健将)运动员比久坐个体冠状动脉钙化(coronary artery calcium,CAC)评分更高。尚没有研究评估具有低动脉粥样硬化风险特征的专业运动员的CAD患病率。 | 刘莉 叶鹏 Merghani A Maestrini V Rosmini S Cox AT Dhutia H Bastiaenen R David S Yeo TJ Narain R Malhotra A Papadakis M Wilson MG Tome M AlFakih K Moon JC Sharma S | 2017 | 中华高血压杂志2017，25，6： | 8 |
| 2 | Role of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in cryoballoon ablation outcomes for paroxysmal atrial fibrillation显示文摘BACKGROUND Cryoballoon ablation(CBA)is recommended for patients with paroxysmal atrial fibrillation(AF)refractory to antiarrhythmic drugs.However,only 80%of patients benefit from initial CBA.There is growing evidence that pretreatment with angiotensin-converting enzyme inhibitors(ACEIs)and angiotensin receptor blockers(ARBs)decreases the recurrence of AF postablation,particularly in nonparoxysmal AF undergoing radiofrequency ablation.The role of ACEIs and ARBs in patients with paroxysmal AF in CBA remains unknown.We decided to investigate the role of ACEIs and ARBs in preventing the recurrence of atrial arrhythmia(AA)following CBA for paroxysmal AF.AIM To investigate the role of ACEIs and ARBs in preventing recurrence of AA following CBA for paroxysmal AF.METHODS We followed 103 patients(age 60.6±9.1 years,29%women)with paroxysmal AF undergoing CBA 1-year post procedure.Recurrence was assessed by documented AA on electrocardiogram or any form of long-term cardiac rhythm monitoring.A multivariable Cox proportional hazard model was used to assess if ACEI or ARB treatment predicted the risk of AA recurrence.RESULTS After a 1-year follow-up,19(18.4%)participants developed recurrence of AA.Use of ACEI or ARB therapy was noted in the study population.Patients on ACEI/ARB had a greater prevalence of hypertension and coronary artery disease.On a multivariate model adjusted for baseline demographics and risk factors for AF,ACEI or ARB therapy did not prevent recurrence of AA following CBA(P=0.72).Similarly,on Kaplan–Meier analysis pretreatment with ACEI/ARB did not predict the time to first recurrence of AA(P=0.2173).CONCLUSION In our study population,preablation treatment with an ACEI or ARB had no influence on the recurrence of AA following CBA for paroxysmal AF. | Ibragim Al-Seykal Abhishek Bose Parag A Chevli Zeba Hashmath Nitish Sharma Ajay K Mishra Douglas Laidlaw | 2022 | World Journal of Cardiology2022，14，10： | 2 |
| 3 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 4 | Perils of Rib Fractures显示文摘 | Sharma Om P Oswanski Michael F Jolly Shashank Lauer Sherry K Dressel Rhonda Stombaugh Heather A | 2008 | The American Surgeon2008，，4： | 2 |
| 5 | A study of optimal model lag and spatial inputs to artificial neural network for rainfall forecasting显示文摘 | K C Luk J E Ball A sharma | 2000 | Journal of Hydrology2000，227，： | 1 |
| 6 | Clinical relevance of oxidative stress in male factor infertility:an update显示文摘 | Aqarwal A Makker K Sharma R | 2008 | Am J Repord Immunol2008，59，1： | 1 |
| 7 | Interactions of climatic factors affecting milk yield and composition显示文摘 | Sharma A K | 1988 | Dairy Science1988，，71： | 1 |
| 8 | Studies on anodization of magnesium alloy for thermal control applications显示文摘 | Sharma A K Rani R U Giri K | 1997 | Met Finish1997，95，3： | 1 |
| 9 | A preliminary study of pulsed streamer corona discharge for the degradation of phenol in aqueous solutions显示文摘 | Sharma A K Locke B R Arcc P | 1993 | Hazard Waste Hazard Mater1993，10，5： | 1 |
| 10 | Effect of dietary and abomasally infused choline on milk production responses of lactating dairy cows显示文摘 | Sharma B K R A Erdman | 1989 | J Nutri1989，119，： | 1 |
| 11 | Comparative cardiopulmonary effects of xylazine and detomidine in goats显示文摘 | Dilipkumar D Sharma A K Gupta O P | 1998 | Indian Veterinary Journal1998，75，10： | 1 |
| 12 | Simultaneous visual detection of pulse chirp and temporal asymmetry in ultrashort laser pulses using analysis of unbalanced interferometrie correlation envelope (ICE) functions 显示文摘 | SHARMA A K NAIK P A GUPTA P D | 2007 | Applied Physics B2007，87，4： | 1 |
| 13 | Voltammetric sensor for barbituric acid based on a solgel derivated molecularly imprinted polymer brush grafted to graphite electrode显示文摘 | PATEL A K SHARMA P S PRASAD B B | 2009 | International Journal of Pharmaceutics2009，371，1： | 1 |
| 14 | Effect of ceramic material on heat dissipation from multi-stage depressed collector used in high frequency travelling-wave tubes 显示文摘 | GAHLAUT v SHARMA R K SRIVASTAVA v ALVI P A GHOSH S K | 2013 | Indian Journal of Pure & Applied Physics2013，51，： | 1 |
| 15 | A study of optimal model lag and spatial inputs to artificial neural net-work for rainfall forecasting显示文摘 | Luk K C Ball J E Sharma A | | 0，，： | 1 |
| 16 | Cognitive workload o{ air tra{{ic controllers in area control center of mumbai enroute airspace 显示文摘 | Pant R Taukari A Sharma K | 2012 | Journal of Psychosocial Research2012，7，2： | 1 |
| 17 | Solvent free aldol condensation of propanal to 2-methylpentenal using solid base catalysts 显示文摘 | SHARMA S K PARIKH P A JASRA R V | 2007 | Journal of Molecular Catalysis A: Chemical2007，278，12： | 1 |
| 18 | Mutation in OsLMS, a gene encoding a protein with two double-stranded RNA binding motifs, causes lesion mimic phenotype and early senescence in rice ( Oryza sativa )显示文摘 | Undan J Tamiru M Abe A Yoshida K Kosugi S Takagi H Yoshida K Kanzaki H Saitoh H Fekih R Sharma S Undan J Yano M Terauchi R | 2012 | Genes Genetic System2012，87，3： | 1 |
| 19 | Influence of properties of bituminous binders on the strength of formed coke显示文摘 | SHARMA A K DAS B P TRIPATHI P S M | 2002 | Fuel Processing Technology2002，75，3： | 1 |
| 20 | Anti-anxiety studies on extracts of Passiflora incamata Linneaus 显示文摘 | Dhawan K Kumar S Sharma A | 2001 | J Ethnopharmacol2001，78，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员