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| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | A Suevey on Con- tent based Medical Image Retrieval for Mri Brain Images 显示文摘 | Sharmila G Saraswathi D Ramkumar R | 2014 | International Journal of Research in Engineering and Technology2014，3，19： | 1 |
| 3 | Thermo mechani- cal behavior of unsaturated polyester toughed epoxy-clay hybrid nan composites显示文摘 | Chozhan C K Alagar M Sharmila R J | 2007 | Journal of Polymer Research2007，4，14： | 1 |
| 4 | Multiple organ dysfunction syndrome following single wasp sting显示文摘 | Sharmila R R Chetan G Narayanan P | 2007 | Indian J Pediatr2007，74，： | 1 |
| 5 | Toughened polyester matrices for advanced composites显示文摘 | Sharmila R Josephine Premkumar S Alagar M | 2007 | Journal of Applied Polymer Science2007，103，1： | 1 |
| 6 | Statistical study on physicochemical characteristics of groundwater in and around Namakkal, Tarnilnadu, India显示文摘 | KARUNAKARAN K THAMILARASU P SHARMILA R | 2009 | E Journal of Chemistry2009，6，3： | 1 |
| 7 | A model for projectingflight delays during irregular operation conditions显示文摘 | Khaled A Sharmila S Sidhartha R | 2004 | Journal of Air TransportManagement2004，10，6： | 1 |
| 8 | Smart coating for corrosion protection by adopting nano particles显示文摘 | Selvakumar N Jeyasubramanian K Sharmila R | 2012 | Progress in Organic Coatings2012，74，3： | 1 |
| 9 | Chemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in in?vivo model显示文摘 | Sharmila G Bhat F A Arunkumar R | 2014 | Clin Nutr2014，33，4： | 1 |
| 10 | Multiple organ dysfunc- tion syndrome following single wasp sting 显示文摘 | Sharmila R R Chetan G Narayanan P | 2007 | Indian J Pediatr2007，74，12： | 1 |
| 11 | Statistical study on physicochemical characteristics of groundwater in and around Na- makkal, Tamilnadu, India显示文摘 | Kamnakaran K Thamilarasu P Sharmila R | 2009 | Journal of Chemistry2009，6，3： | 1 |
| 12 | Shot boundary detection algorithm based on color texture moments显示文摘 | Shekar B H Sharmila K M Holla R | 2011 | Communi-cations in Computer and Information Science2011，142，3： | 1 |
| 13 | Effect of diallyl di- sulfide on insulin-like growth factor signaling molecules involved in cell survival and proliferation of human prostate cancer cells in vitro and in silico approach through docking analysis 显示文摘 | Arunkumar R Sharmila G Elumalai P | 2012 | Phytomedi- cine2012，19，10： | 1 |
| 14 | Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer显示文摘 | SHARMILA P MARK R P | 2008 | Expert Opin Investig Drugs2008，17，12： | 1 |
| 15 | Anti-tumor activity of rosmarinic acidin7,12-dimethylbenz (a)anthracene (DMBA) induced skincarcinogenesis in Swiss albino mice 显示文摘 | Sharmila R Manoharan S | 2012 | Indian J Exp Biol2012，50，3： | 1 |
| 16 | Multiple organ dysfunction syndrome following single wasp sting显示文摘 | Sharmila R R Chetan G Narayanan P | 2007 | Indian J Pediatr2007，74，12： | 1 |
| 17 | Fractal analysis of bone X-Ray tomographic microscopy projections显示文摘 | JENNANE R OHLEY W J SHARMILA M | 2001 | IEEE Transactions on Medical Imaging2001，20，5： | 1 |
| 18 | Multiple organdysfunction syndrome following sin- gle wasp sting显示文摘 | SHARMILA R R CHETAN G NARAYANAN P | 2007 | Indian J PedPediatr2007，74，： | 1 |
| 19 | Effect of diallyl disul- fide on insulin - like growth factor signaling molecules involved in cell survival and proliferation of human prostate cancer cells in vitro and in silico approach through docking analysis 显示文摘 | Arunkumar R Sharmila G Elumalai P | 2012 | Phytomedicine2012，19，10： | 1 |
| 20 | Multiple organ dysfunction syndrome following single wasp sting显示文摘 | Sharmila R R Chetan G Narayanan P Srinivasan S | 2007 | In dian J Pediatr2007，74，： | 1 |
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