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| 1 | Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic显示文摘Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines. | Shashi Kant Singh Saurabh K Sinha SK Prasad R Kumar Bhawani S Bithu S Sadish Kumar P Singh | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 4 |
| 2 | Comparison of eigensensitivity and ANN based methods in model updating of an eight-story building显示文摘Analytical models prepared from field drawings do not generally provide results that match with experimental results.The error may be due to uncertainties in the property of materials,size of members and errors in the modelling process.It is important to improve analytical models using experimentally obtained data.For the past several years,data obtained from ambient vibration testing have been successfully used in many cases to update and match dynamic behaviors of analytical models with real structures.This paper presents a comparison between artificial neural network(ANN) and eigensensitivity based model updating of an existing multi-story building.A simple spring-mass analytical model,developed from the structural drawings of the building,is considered and the corresponding spring stiffness and lumped mass of all floors are chosen as updating parameters.The advantages and disadvantages of these updating methods are discussed.The advantage is that both methods ensure a physically meaningful model which canbe further employed in determining structural response and health monitoring. | Prabakaran K Ashok Kumar Shashi Kant Thakkar | 2015 | Earthquake Engineering and Engineering Vibration2015，14，3： | 3 |
| 3 | Adsorption of resorcinol and catechol on granular activated carbon: Equilibriun and kinetics显示文摘 | Arinjay K Shashi K Surendra K 2003 | 2003 | Carbon2003，41，15： | 1 |
| 4 | Differential Pulse Adsorptive Stripping Voltammetric Determination of Bifenthrin in Formulations and Vegetables显示文摘 | KUMAR K N SHASHI THRIVENI | 2006 | Journal of the Electrochemical Society of India2006，55，1： | 1 |
| 5 | Triterpenoids 显示文摘 | Shashi B M Ashoke K N Gita R | 1992 | Phyto-chemistry1992，31，7： | 1 |
| 6 | An evolutionary game-theoretic approach to the strategies of community members under joint forest management regime 显示文摘 | Chander S Shashi K | 2007 | Forest Policy and Economics2007，9，7： | 1 |
| 7 | Myofibrillar protein degradation of carp (Labeorohita(Hamilton)) muscle after post-mortem unfrozen and frozen storage显示文摘 | SHASHI K J PARDEEP K J TALESARA C L | 2001 | J Science of Food and Agriculture2001，81，： | 1 |
| 8 | ^13 C-NMR spectra of pentacyclic tfiterpenoids a compilation and some salient features显示文摘 | Shashi B M Asish P K | 1994 | Phytochemistry1994，37，6： | 1 |
| 9 | ^13C - NMR spectra of pentacylic triterpenoids - a compilation and some salient features 显示文摘 | Shashi B M Asish P K | 1994 | Phytochemistry1994，37，6： | 1 |
| 10 | ^13C-NMR spectra of pentacyclic triterpenoids a compilation and some salient features显示文摘 | Shashi B M Asish P K | 1994 | Phytochemistry1994，37，6： | 1 |
| 11 | He global competitiveness of the Chinese wooden furniture industry显示文摘 | XIAO H YALI W SHASHI K | 2009 | Forest Policy and Economics2009，11，8： | 1 |
| 12 | ^13 C-NMR spectra of pentacyclic triterpenoids-A compilation and some salient features 显示文摘 | Shashi B M Asish P K | 1994 | Phytochemistry1994，37，6： | 1 |
| 13 | Enhanced apop- totic effect of curcumin loaded solid lipid nanoparticles显示文摘 | VANDITA K SHASHI B SANTOSH KG | 2012 | Mql Pharm2012，9，12： | 1 |
| 14 | An Evolutionary Game-theoretic Approach to the Strategies of Community Members under Joint Forest Management Regime 显示文摘 | Chander S Shashi K | 2007 | Forest Policy and Economics2007，9，7： | 1 |
| 15 | Plastid - expressed betaine alde- hyde dehydrogenase gene in carrot cultured cells, roots, and leaves confers enhanced salt tolerance 显示文摘 | Shashi K Amit D Henry D | 2004 | Plant Physiology2004，136，： | 1 |
| 16 | Determination of micropore volume and surface area of zeolite molecular sieves by D-R and D-A equations:a comparative study显示文摘 | VYAS R SHASHI K KUMAR S | | 0，，05： | 1 |
| 17 | Coliquefaction of coal and black liquor to environmentally acceptable liquid fuels显示文摘 | Jongwon K Shashi B | 1999 | Energy Sources1999，21，9： | 1 |
| 18 | 13C-NMR spectra of pentacyclie triterpenoids-A compilation and some salient features 显示文摘 | SHASHI B M ASISH P K | 1994 | Phytochemistry1994，37，6： | 1 |
| 19 | ^13C NMR spectra of pentacyclic triterpenoids A compilation and some calient features 显示文摘 | SHASHI B M ASISH P K | 1994 | Phytochemistry1994，37，： | 1 |
| 20 | Discrimination analysis of India tea varieties based upon color under optimum illumination 显示文摘 | Amit L Neelam R P Shashi S Amod K | 2013 | Journal of Food Measurement and Characterization2013，7，2： | 1 |
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