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| 1 | 中草药对良性前列腺增生的疗效及安个性:随机对照试验的系统回顾显示文摘中草药经常被用于治疗良性前列腺增生,但其疗效及安全性仍有待证实。为了比较单用中草药和中药与西药联合治疗良性前列腺增生的疗效及副作用,两位独立的评审员在主要的电子数据库中检索了单用中草药或中草药与西药联用与安慰剂或单用西药之间比较的随机对照试验,于动检索了相关期刊和灰色文献。评估的结果包括泌尿系统症状、尿动力学检测、小草药的效果优于西药。中草药的副作用发生需要有大型的质量更高的随机对照试验。 | Chun Ho Ma Wai Ling Lin Sing Leung Lui Xun-Yuan Cai Vivian Taam Wong Kun-Yuan Cai Eric Zie Zhang-Jin Zhang | 2013 | Asian Journal of Andrology2013，15，4： | 6 |
| 2 | Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients显示文摘 | Bertrand Baujat Hélène Audry Jean Bourhis Anthony T.C. Chan Haluk Onat Daniel T.T. Chua Dora L.W. Kwong Muhyi al-Sarraf Kwan-Hwa Chi Masato Hareyama Sing F. Leung Kullathorn Thephamongkhol Jean-Pierre Pignon | 2006 | International Journal of Radiation Oncology, Biology, Physics2006，，1： | 2 |
| 3 | Inhibition of intestinal and renal Na + -glucose cotransporter by naringenin显示文摘 | Jian Mei Li Chun Tao Che Clara B.S. Lau Po Sing Leung Christopher H.K. Cheng | 2005 | International Journal of Biochemistry and Cell Biology2005，，5： | 2 |
| 4 | Erastin-induced ferroptosis is a regulator forthe growth and function of humanpancreatic islet-like cell clusters显示文摘Ferroptosis is a newly identified and novel form of cell death, which is characterized by an iron- and reactiveoxygen species (ROS)-dependent manner. Potential utility of ferroptotic cell death has been recently proposed forcancer treatment. Meanwhile, ROS generation and apoptosis are inherently consequent to cell apoptosis anddysfunction during islet cell preparation and transplantation. Whether ferroptosis induction is a regulator for cellviability and function in human pancreatic islet-cell clusters (ICCs) derived from pancreatic progenitor cells (PPCs)remains elusive. We thus sought to induce ferroptosis in our established cell culture system of human PPCs/ICCs,examine the effects of ferroptosis on ICCs, and explore the potential regulatory pathways involved. Our resultsshowed that ICCs were prone to the use of ferroptosis-inducing and inhibiting agents under our culture conditions.Erastin, a ferroptosis inducer, was found to trigger ferroptosis in ICCs, without the apparent detection of other typesof cell death involved, such as apoptosis and autophagy. In corroboration, the use of ferroptosis inhibitor,ferrostatin-1 (Fer-1), was found to enhance the cell viability of ICCs and prevent them from ferroptosis as well asimprove its function. Mechanistically, the erastin-induced ferroptosis in ICCs was probably mediated via activation ofJNK/P38/MAPK pathways and upregulation of NOX4 expression. Together, our findings may provide a scientificbasis of ferroptosis inhibition as a potential for the amelioration of ICC survival and functionality during islettransplantation in diabetic patients. | Xing Yu Li Po Sing Leung | 2020 | Cell Regeneration2020，9，1： | 2 |
| 5 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 6 | Wavelet transform-based stress-time history editing of horizontal axis wind tur bine blades显示文摘 | PANU PRATUMNOPHARAT PAK SING LEUNG RICHARD S COURT | | 0，，： | 1 |
| 7 | Progression of Middle Cerebral Artery Occlusive Disease and Its Relationship With Further Vascular Events After Stroke显示文摘 | Ka Sing Wong Huan Li Wynnie W.M. Lam Yu Leung Chan Richard Kay | 2002 | Stroke: Journal of the American Heart Association2002，，2： | 1 |
| 8 | Early detection of nasopharyngeal carcinoma by plasma Epstein‐Barr virus DNA analysis in a surveillance program显示文摘 | K. C. Allen Chan Emily C. W. Hung John K. S. Woo Paul K. S. Chan Sing‐Fai Leung Franco P. T. Lai Anita S. M. Cheng Sze Wan Yeung Yin Wah Chan Teresa K. C. Tsui Jeffrey S. S. Kwok Ann D. King Anthony T. C. Chan Andrew C. van Hasselt Y. M. Dennis Lo | 2013 | Cancer2013，，10： | 1 |
| 9 | Spousal renal donor transplantation in Chinese subjects:a ten year experience from a single centre显示文摘 | SYDNEY TANG SING LEUNG CHI YUEN L O | 2004 | Nephrol Dial Transplant2004，19，： | 1 |
| 10 | Randomized phase II trial of concurrent cidplatin - radiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyttgeal carcinoma显示文摘 | Edwin P Hui Brigette B Ma Sing F Leung | 2009 | J Clin Oncol2009，27，2： | 1 |
| 11 | Using investment portfolio return to combine foreasts: multiobjective approach显示文摘 | Leung M T Daouk H Chen an Sing | 2001 | European journal of Operational Research2001，134，： | 1 |
| 12 | Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients显示文摘 | Bertrand Baujat Hélène Audry Jean Bourhis Anthony T.C. Chan Haluk Onat Daniel T.T. Chua Dora L.W. Kwong Muhyi al-Sarraf Kwan-Hwa Chi Masato Hareyama Sing F. Leung Kullathorn Thephamongkhol Jean-Pierre Pignon | 2006 | International Journal of Radiation Oncology Biology Physics2006，，1： | 1 |
| 13 | On-line training and pruning for recursive least square algorithms显示文摘 | Chi Sing Leung Kwok Wo Wong | 1996 | Electronics Letters1996，32，23： | 1 |
| 14 | Use of Transcranial Doppler Ultrasound to Predict Outcome in Patients With Intracranial Large-Artery Occlusive Disease显示文摘 | Ka Sing Wong Huan Li Yu Leung Chan Anil Ahuja Wynnie W. M. Lam Agatha Wong Richard Kay | 2000 | Stroke: Journal of the American Heart Association2000，，11： | 1 |
| 15 | Treatment of pure membranous lupus nephropathy with prednisone and azathioprine: an open-label trial显示文摘 | Chi Chiu Mok King Yee Ying Chak Sing Lau Cheuk Wan Yim Woon Leung Ng Woon Sing Wong Tak Cheung Au | 2004 | American Journal of Kidney Diseases2004，，2： | 1 |
| 16 | On-line training and pruning for reeursive least square algorithms显示文摘 | Chi Sing Leung Kwok Wo Wong | 1996 | Electronics Letters1996，32，23： | 1 |
| 17 | An update on the islet renin–angiotensin system显示文摘 | Qianni Cheng Po Sing Leung | 2011 | Peptides2011，，5： | 1 |
| 18 | Use of transcranial dopple ultrasound to predict outcome in patients with intracranial large artery occlusive disease显示文摘 | Ka Sing Wong Huan Li Yu Leung Chan | 2000 | Stroke2000，31，12： | 1 |
| 19 | Mitogen-Activated Protein Kinases and Chemoresistance in Pancreatic Cancer Cells显示文摘 | Yupei Zhao Songjie Shen Junchao Guo Herbert Chen David Yu Greenblatt J?rg Kleeff Quan Liao Ge Chen Helmut Friess Po Sing Leung | 2006 | Journal of Surgical Research2006，，2： | 1 |
| 20 | High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines显示文摘 | Hong Zhu David Chi Leung Lam Kam Chu Han Vicky Pui Chi Tin Wai Sing Suen Elaine Wang Wah Kit Lam Wei Wen Cai Lap Ping Chung Maria Pik Wong | 2006 | Cancer Letters2006，，1： | 1 |
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