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| 1 | 认知行为疗法与佐匹克隆治疗老年慢性原发性失眠患者的比较:一项随机对照试验显示文摘Context: Insomnia is a common condition in older adults and is associated with a number of adverse medical, social, and psychological consequences. Previous research has suggested beneficial outcomes of both psychological and pharmacological treatments, but blinded placebo-controlled trials comparing the effects of these treatments are lacking. Objective: To examine short-and long-term clinical efficacy of cognitive behavioral therapy (CBT) and pharmacological treatment in older adults experiencing chronic primary insomnia. Design, Setting, and Participants: A randomized, double-blinded, placebo-controlled trial of 46 adults (mean age, 60.8 y; 22 women) with chronic primary insomnia conducted between January 2004 and December 2005 in a single Norwegian university-based outpatient clinic for adults and elderly patients. Intervention: CBT (sleep hygiene, sleep restriction, stimulus control, cognitive therapy, and relaxation; n=18), sleep medication (7.5-mg zopiclone each night; n=16), or placebo medication (n=12). All treatment duration was 6 weeks, and the 2 active treatments were followed up at 6 months. Main Outcome Measures: Ambulant clinical polysomnographic data and sleep diaries were used to determine total wake time, total sleep time, sleep efficiency, and slow-wave sleep (only assessed using polysomnography) on all 3 assessment points. Results: CBT resulted in improved short-and long-term outcomes compared with zopiclone on 3 out of 4 outcome measures. For most outcomes, zopiclone did not differ from placebo. Participants receiving CBT improved their sleep efficiency from 81.4%at pretreatment to 90.1%at 6-month follow-up compared with a decrease from 82.3%to 81.9%in the zopiclone group. Participants in the CBT group spent much more time in slow-wave sleep (stages 3 and 4) compared with those in other groups, and spent less time awake during the night. Total sleep time was similar in all 3 groups; at 6 months, patients receiving CBT had better sleep efficiency using polysomnography than those taking zopiclone. Conclusion: These results suggest that interventions based on CBT are superior to zopiclone treatment both in short-and long-term management of insomnia in older adults. | Sivertsen B Omvik S Pallesen S. 谢琰臣 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，11： | 3 |
| 2 | Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial 显示文摘 | Sivertsen B Omvik S Pallesen S | 2006 | JAMA2006，295，24： | 1 |
| 3 | A 10-year trend of insomnia prevalence in the adult Norwegian population 显示文摘 | Pallesen S Sivertsen B Nordhus IH | 2014 | Sleep Med2014，15，2： | 1 |
| 4 | Small-scale experiments on stabilizing riser slug flow显示文摘 | Sivertsen H Storkaas E Skogestad S | 2010 | Chemical Engineering Research and Design2010，88，2： | 1 |
| 5 | Smallscale experiments on stabilizing riser slug flow 显示文摘 | SIVERTSEN H STORKAAS E SKOGESTAD S | 2010 | Chemical Engineering Research and Design2010，88，： | 1 |
| 6 | Origin and distribution of polycyelic aromatic hydrocarbons in surficial sediments from the Savannah River显示文摘 | SANDERS M SIVERTSEN S SCOTT G | 2002 | Archives of Environmental Contamination and Toxicology2002，43，： | 1 |
| 7 | Detection of nema- todes in Cod (Gadus morhua) fillets by imaging spectroscopy显示文摘 | HEIA K SIVERTSEN A H STORMO S K | 2007 | Journal of Food Science2007，72，1： | 1 |
| 8 | The effect of OSAS on sick leave and work disability 显示文摘 | Sivertsen B Overland S Glozier N | 2008 | Eur Respir J2008，32，6： | 1 |
| 9 | Detection of nematodes in Cod ( Gadus morhua) fillets by imaging spectroscopy 显示文摘 | Heia K Sivertsen A Stormo S | 2008 | Joumal of Food Science2008，1，： | 1 |
| 10 | Expression of Snail, Slug and Sip1 in malignant mesothelioma effusions is associat- ed with matrix metalloproteinase, but not with cadherin ex- pression 显示文摘 | Sivertsen S Hadar R Elloul S | 2006 | Lung Cancer2006，54，3： | 1 |
| 11 | Inhibition of the MAP kinase cascade blocks heregulin - induced cell cycle progression in T -47D human breast cancer cells 显示文摘 | F1DDES R J JANES P W SIVERTSEN S P | 1998 | Oncogene1998，16，21： | 1 |
| 12 | Relation of total homocysteine and lipid levels in children to premature cardiovascular death in male relatives显示文摘 | Tonstad S Refsum H Sivertsen M | 1996 | Pediatr Res1996，40，： | 1 |
| 13 | Origin and distribution of polycyclic aromatic hydrocarbons in surficial sediments from the Savannah River 显示文摘 | Sander M Sivertsen S Scott G | 2002 | Arch Environ Contam Toxicol2002，43，8： | 1 |
| 14 | Origin and distribution of polycyclic aromatic hydrocarbons in surficial sediments from the Savannah river显示文摘 | Sivertsen S Scott G | 2002 | Arch Environ Contam Toxicol2002，43，： | 1 |
| 15 | The epidemiology of insomnia: associations with physical and mental health : the HUNT-2 study 显示文摘 | Sivertsen B Krokstad S Overland S | 2009 | J Psychosomatic Res2009，67，2： | 1 |
| 16 | Cadherin expression inovarian carcinoma and malignant mesothelioma cell effusions显示文摘 | Sivertsen S Berner A Michael CW | 2006 | Acta Cytol2006，50，6： | 1 |
| 17 | Origin and distribution of polycyclic aromatic hydrocarbons in surficial sediments from the Savannah Rriver显示文摘 | SANDERS M SIVERTSEN S SCOTT G | 2002 | Archives of Environment Contamination and Toxicology2002，43，： | 1 |
| 18 | Origin and distribution of polycyclic aromatic hydrocarbons in surficial sediments from the Savannah River显示文摘 | Sivertsen S Scott G | 2002 | Arch Environ Contam Toxicol2002，43，8： | 1 |
| 19 | The epidemiology of insomnia: Associations with physical and mental health: The HUNT-2 study显示文摘 | Sivertsen B Krokstad S Overland S | 2009 | Journal of Psychosomatic Research2009，67，2： | 1 |
| 20 | Cadherin expression in ovarian carcinoma and malignant mesothelioma cell effusions显示文摘 | Sivertsen S Berner A Michael CW | | 0，，： | 1 |
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