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| 1 | Association between thrombotic risk factors and extent of fibrosis in patients with non-alcoholic fatty liver diseases显示文摘AIM: To evaluate the prevalence of genetic and acquired prothrombotic risk factors and their association with the extent of fibrosis and fatty infiltration in patients with non-alcoholic fatty liver disease (NAFLD).METHODS: Forty-four patients with chronic hepatitis (28 men and 16 women, with mean age of 45±11 and 49±12 years, respectively) constituted the patient population of this study. The groups were divided as follows: 15 patients with fatty liver (FL); 15 with non-alcoholic steatohepatitis (NASH); 14 with chronic viral hepatitis (CH) diagnosed by histology and liver technetium scan or ultrasound; and 10 healthy individuals. Thrombophilic, coagulation factors and genetic mutations were diagnosed by standard hemostatic and molecular coagulation assays.RESULTS: Activated protein C (APC) resistance and protein S were the most prevalent thrombotic risk factors (6% and 10% in NAFLD vs 21% and 14% in CH; P<0.01 and P<0.05, respectively). One thrombotic risk factor was identified in 41% of patients (23% mild fibrosis, 18% severe fibrosis) and two thrombotic risk factors in 6% of patients with NAFLD and severe fibrosis. While no differences in APC ratio, lupus anticoagulant, fibrinogen, factor V Leiden,prothrombin, and MTHFR mutation were found. Protein S levels were significantly lower in NASH patients than in patients with FL alone (92±19 vs106±2, P<0.01). Protein C levels were markedly higher in patients with NAFLD and mild or severe fibrosis as compared to the patients with CH, respectively (128±40 vs96±14, P<0.001 or 129±36 vs 88±13, P<0.01).CONCLUSION: Up to 46% of patients with NAFLD may have thrombotic risk factors, and the presence of thrombotic risk factors is correlated with the extent of hepatic fibrosis,suggesting a crucial role of the coagulation system in the pathogenesis of hepatic fibrosis. | N Assy I Bekirov Y Mejritsky L Solomon S Szvalb O Hussein | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 2 | Effect of different levels of cactus (Opuntiacus-indica) inclusion on feed intake, digestibility and body weight gain in tel (Eragrostis re f) straw-based feeding of sheep 显示文摘 | Tikabo G Solomon M Alemu Y | 2006 | Animal Feed Science and Technology2006，131，： | 1 |
| 3 | Microstructural characterization of Ni-Mn-Ga ferromagnetic shape memory alloy powders显示文摘 | SOLOMON V C SMITH D J TANG Y J BERKOWITZ A E | 2004 | J Appl Phys2004，95，： | 1 |
| 4 | Synthesis and QSAR studies on thiazolidinones as anti-HIV agents 显示文摘 | Rawal R K Solomon V R Prabhakar Y S | 2005 | Comb Chem High Throughput Screen2005，8，5： | 1 |
| 5 | Visibility of wavelet quantization noise显示文摘 | Watson A B Yang G Y Solomon J A | 1997 | IEEE Trans Image Proc1997，6，： | 1 |
| 6 | p27^kipl, a cyclin-cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest显示文摘 | Polyak K Kato J Y Solomon M J | 1994 | Genes Dev1994，8，： | 1 |
| 7 | P27kipl, a cyclin-CDK into cell arrest显示文摘 | Polyak K Kato J Y Solomon M J | 1994 | Cenes Dev1994，8，： | 1 |
| 8 | Magnetocaloric effect in NiMnGa particles produced by spark erosion显示文摘 | TANG Y J SOLOMON V C SMITH D J HARPER H BERKOWITZ A E | 2005 | J Appl Phys2005，97，309： | 1 |
| 9 | Effect ofcrizotinib on overall survival in patients with advancednon-small-cell lung cancer harbouring ALK generearrangement:a retrospective analysis 显示文摘 | Shaw A T Yeap B Y Solomon B J | 2011 | Lancet Oncol2011，12，11： | 1 |
| 10 | Effect of NaC1 on the carboxylating activity of tubisco from tamarlx jordanis in the repesence and absence of proline -related compatible solutes 显示文摘 | Solomon A Beer S Waisel Y | 1994 | Physiol1994，90，： | 1 |
| 11 | Virility of Wavelet Quantization Noise显示文摘 | Andrew B Watson Gloria Y Yang Joshua A Solomon | 1997 | IEEE transaction on image processing1997，6，8： | 1 |
| 12 | How often does it rain?显示文摘 | SUN Y SOLOMON S DA1 A | 2006 | J Climate2006，19，6： | 1 |
| 13 | Eeffect of, Nacl on the carboxylating activity of Rubisco from Tamarix jordanis in the presence and absence of proline-related compatible solutes显示文摘 | Beer S Wasisel Y | 1994 | Physiol Plant1994，90，： | 1 |
| 14 | Evaluation of different clini- cal sample types in diagnosis of human enterovirus 71 - associated hand - foot - and - mouth disease显示文摘 | Ooi MH Solomon T Podin Y | 2007 | J Clin Microbiol2007，45，6： | 1 |
| 15 | Evaluation of different clinical sample types in diagnosis of human enterovirus 71-associated hand- foot-and-mouth disease显示文摘 | Ooi MH Solomon T Podin Y | 2007 | J Clin Microbiol2007，45，6： | 1 |
| 16 | Self--healing poly- meric materials: A review of recent developments显示文摘 | Wu D Y Meure S Solomon D | 2008 | Progress in Polymer Science2008，33，5： | 1 |
| 17 | Visibility of wavelet quantization noise显示文摘 | WATSON A B YANG G Y SOLOMON J A VILLASENNOR J | 1997 | IEEE Trans On Image Processing1997，6，8： | 1 |
| 18 | Evaluation of different clinical sample types in diagnosis of human enterovinis 71-associated hand-foot-mouth disease显示文摘 | Ooi MH Solomon T Podin Y | 2007 | J Clin Microbiol2007，45，6： | 1 |
| 19 | Visibility of wavelet qantization noise显示文摘 | WASTON A B YANG G Y SOLOMON J A | 1997 | IEEE Trans on Image Processing1997，6，8： | 1 |
| 20 | Ethephon:A versatile growth regulator for sugar cane industry显示文摘 | LI Y R SOLOMON S | 2003 | Sugar Tech2003，5，4： | 1 |
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