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| 1 | Stand-level biomass models for predicting C stock for the main Spanish pine species显示文摘Background:National and international institutions periodically demand information on forest indicators that are used for global reporting.Among other aspects,the carbon accumulated in the biomass of forest species must be reported.For this purpose,one of the main sources of data is the National Forest Inventory(NFI),which together with statistical empirical approaches and updating procedures can even allow annual estimates of the requested indicators.Methods:Stand level biomass models,relating the dry weight of the biomass with the stand volume were developed for the five main pine species in the Iberian Peninsula(Pinus sylvestris,Pinus pinea,Pinus halepensis,Pinus nigra and Pinus pinaster).The dependence of the model on aridity and/or mean tree size was explored,as well as the importance of including the stand form factor to correct model bias.Furthermore,the capability of the models to estimate forest carbon stocks,updated for a given year,was also analysed.Results:The strong relationship between stand dry weight biomass and stand volume was modulated by the mean tree size,although the effect varied among the five pine species.Site humidity,measured using the Martonne aridity index,increased the biomass for a given volume in the cases of Pinus sylvestris,Pinus halepensis and Pinus nigra.Models that consider both mean tree size and stand form factor were more accurate and less biased than those that do not.The models developed allow carbon stocks in the main Iberian Peninsula pine forests to be estimated at stand level with biases of less than 0.2 Mg·ha^(-1).Conclusions:The results of this study reveal the importance of considering variables related with environmental conditions and stand structure when developing stand dry weight biomass models.The described methodology together with the models developed provide a precise tool that can be used for quantifying biomass and carbon stored in the Spanish pine forests in specific years when no field data are available. | Ana Aguirre Miren del Río Ricardo Ruiz-Peinado Sonia Condés | 2021 | Forest Ecosystems2021，8，2： | 4 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 4 | Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention 显示文摘 | Sonia R | 2007 | Journal of Nutritional Biochemistry2007，18，7： | 1 |
| 5 | Journal of Colloid and Interface Science显示文摘 | Clara P Sonia P Ana R | 2007 | 316:5702007，316，： | 1 |
| 6 | A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates显示文摘 | Blin Guillaume Nury David Stefanovic Sonia Neri Tui Guillevic Oriane Brinon Benjamin Bellamy Valérie Rücker-Martin Catherine Barbry Pascal Bel Alain Bruneval Patrick Cowan Chad Pouly Julia Mitalipov Shoukhrat Gouadon Elodie Binder Patrice | 2010 | Journal of Clinical Investigation2010，，4： | 1 |
| 7 | Stress Analysis of Reinforced Masonry Arches显示文摘 | Sonia M Maria R Elio S | 2008 | International Journal for Computational Methods in Engineering Science and Mechanics2008，9，2： | 1 |
| 8 | Comparative cytotoxiciry of alachlor,acetochlor,and metolachlor herbicides in isolated rat and cryopreserved human hepatocytes显示文摘 | Vijay M Kale Sonia R Miranda Mitchell S Wilbanks | | 0，，01： | 1 |
| 9 | Supported arua training in patients recently weaned from mechanical centilation 显示文摘 | Porta R Vitaeca M Sonia L | 2005 | Chest2005，128，4： | 1 |
| 10 | Obtaining CeO2-ZrO2 mixed oxides by coprecipitation:role of preparation conditions显示文摘 | Sonia L Claudio A T Roberto R A | 2005 | Applied Catalysis B:Environmental2005，58，34： | 1 |
| 11 | The ultrastructure of the spermatozoon of the lizard Iguana iguana (Reptilia,Squamata,Iguanidae) and the variability of sperm morphology among iguanian lizards显示文摘 | Gustavo H C V Guarino R C Sonia N B | 2004 | Journal of Anatomy2004，204，： | 1 |
| 12 | Studies on blends ofnatural rubber and ethylene propylene diene rubber modified withphosphorylated cardanol prepolymer:Processability,physicomechanicalproperties,and morphology显示文摘 | Menon A R R Sonia T A Sudha J D | 2006 | Journal of AppliedPolymer Science2006，102，51： | 1 |
| 13 | Role of gamma interferon in chemokine expression in the ileum of mice and in a murine intestinal epithelial cell line after Cryptosporidium parvum infection 显示文摘 | Sonia Lacroix-Lamande S Mancassola R Naciri M | 2002 | Infection and Immunity2002，70，4： | 1 |
| 14 | Early oxidative damage in prima-ry cultured trout hepatocytes:a time course study显示文摘 | MICHELA F SONIA R PAOLO C | 2002 | Aquatic Toxicology2002，59，34： | 1 |
| 15 | Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide显示文摘 | Mario A Sonia R Raquel M | 2006 | Toxicol Appl Pharmacol2006，212，2： | 1 |
| 16 | Epstein–Barr virus induction of the Hedgehog signalling pathway imposes a stem cell phenotype on human epithelial cells显示文摘 | Rebecca J Port Sonia Pinheiro‐Maia Chunfang Hu John R Arrand Wenbin Wei Lawrence S Young Christopher W Dawson | 2013 | J Pathol2013，，3： | 1 |
| 17 | Changes in endogenous abscisic acid levels during dormancy release and maintenance of mature seeds: studies with the Cape Verde Islands ecotype, the dormant model of Arabidopsis thaliana 显示文摘 | SONIA A R DENISE B MARIE-HELENE W | 2004 | Planta2004，219，6： | 1 |
| 18 | Second-trimester reference intervals for thyroid tests : the role of ethnicity 显示文摘 | Sonia L L William L R | 2007 | Clin Chem2007，53，： | 1 |
| 19 | Protein kinase C Inhibitor and irradiation-induced apoptosis : relevance of the cytochrome c-mediated Caspase-9 death pathway 显示文摘 | Sonia R Maria S Scott W | 2000 | Cell Growth &Differentiation2000，11，9： | 1 |
| 20 | Texture changes in fresh - cut celeryduring refrigerated storage显示文摘 | Sonia Z V Alicia R C | 2003 | Science of Food and Agriculture2003，83，13： | 1 |
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