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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity显示文摘p53 的 apoptotic 节目由抄写依赖者和抄写无关的小径组成。在后者,在 mitochondrial p53 和 anti-apoptotic 和 mitochondrial 渗透管理者的 Bcl2 家庭的 pro-apoptotic 成员之间的物理相互作用是中央的。用有定义缺乏的 isogenic 房间系统,我们详细描绘 mitochondrial p53 怎么贡献 mitochondrial permeabilization,到什么程度,它的行动依靠另外的关键 Bcl2 家庭成员并且定义它的版本活动。我们证明 mitochondrial p53 在由严重地破坏外部、内部的 mitochondrial 膜正直导致可溶、不可溶解的 apoptogenic 因素的版本是高度有效的。这个行动与 Bax, Bak 和 VDAC 和在 p53 和 cyclophilin D 之间的导致压力的内长的建筑群的形成的野类型的导致 p53 的 oligomerization 被联系,通常在内部膜定位了。导出肿瘤的 p53 异种在激活 Bax/Bak 类脂化合物毛孔是缺乏的。这些行动独立于美洲狮和 Bax。重要地,后者把 mitochondrial 与 cytosolic p53 死亡小径区分开来。 | Sonja Wolff Susan Erster Gustavo Palacios Ute M Moll | 2008 | Cell Research2008，18，7： | 9 |
| 3 | 漂流海藻垫威胁着芬兰西南部群岛海的海底吗?显示文摘借助水底摄像系统和潜水呼吸器,获得1996~1997年夏季漂流海藻群在波罗的海北部的群岛海(Archipelago Sea)发生情况图。研究范围包括从诲滨到海洋50m的深度范围。按藻群的厚度和是否发生缺氧现象(硫化氢气味,黑色沉淀物),亦即藻群潜在的各种生态学影响,对藻群进行了描述和分类。可以区分出三种不同类型的漂流海藻群:藻盖、藻垫和藻床。对藻群在一个生长季节的演替情况进行了研究。开始,藻类在海底聚集成一薄层;之后,这些薄层海藻开始沿海底坡面向下沉,发展为在一定程度上厌氧的藻垫;最后成为完全厌氧的藻床。在研究区东南角的外群岛海,这种现象把为明显。有利于生活史较短的藻类生长、导致漂流藻垫形成的众多因子包括海水中高营养含量、较好的透明度和适易的基质。研究期间,我们深感水下摄像系统是用来研究水下松散藻群的理想工具: | Petri Vahteri Anita Mkinen Sonja Salovius Ilppo Vuorinen 周立志 | 2000 | AMBIO-人类环境杂志2000，29，6： | 2 |
| 4 | Antioxidative activity of phenolic compounds on the metal-ion breakdown of lipid peroxidation system显示文摘 | Bozidar L M Sonja M D Jasna M C | 1998 | Food Chemistry1998，61，4： | 1 |
| 5 | Design,analysis and realization of tendon-based parallel manipulators显示文摘 | MANFRED H FANG Shiqing SONJA M | 2005 | Mechanism and Machine Theory2005，40，4： | 1 |
| 6 | Antioxidative activity of phenolic compounds on the metal-ion breakdownof lipid peroxidation system显示文摘 | Bozdarlm Sonja M D Jasna M C | 1998 | Food Chemistry1998，61，4： | 1 |
| 7 | Signal peptides of secreted proteins of the archaeon Sulfolobus solfataricus:a genomic survey显示文摘 | SONJA V A ARNOLD J M D | 2002 | Arch Microbiol2002，177，： | 1 |
| 8 | Hh-Gli signaling pathway functions and its therapeutic potential in cancer显示文摘 | Sonja L Maja R Vasna M | 2008 | Croat Chem Aeta2008，81，1： | 1 |
| 9 | IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression显示文摘 | AGATHA S AKIRA M SONJA S | 2006 | The Journal of Immunology2006，76，5： | 1 |
| 10 | Driessen Signal peptides of se- creted proteins of the archaeon Sulfolobus solfatari- cus:a genomic survey显示文摘 | Sonja V Arnold J M | 2002 | Arch Microbiol2002，177，3： | 1 |
| 11 | Distribution of cannabinoid receptor 1 ( CB1 ) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin 显示文摘 | Sonja S Martin S Dieter M | 2005 | J Dermatol Sci2005，38，： | 1 |
| 12 | The Impact of Various Re- active Oxygen Species on the Formation of Neutrophil Extracellular Traps显示文摘 | TINA K SONJA M MATTHIAS K | 2012 | Mediators Inflamm2012，2012，84： | 1 |
| 13 | Polyphenolic profile, antioxidant properties and antimicrobial activity of grape skin extracts of 14 Vitis vinifera varieties grown in Dalmatia(Croatia) 显示文摘 | Visnja K Sonja S M Danijela S | 2010 | Food Chemistry2010，119，2： | 1 |
| 14 | Polyphenolic profile, antioxidant properties and antimicrobial activity of grape skin extracts of 14 Vitis vinifera varieties grown in Dalmatia(Croatia) 显示文摘 | Visnja K Sonja S M Dardjela S | 2009 | Food Chemistry2009，，10： | 1 |
| 15 | Stapled transanal rectal resection for symptomatic intussusception: morphological and functional outcome显示文摘 | Reinhold A. Lang Sonja Buhmann Christine Lautenschlager Mario H. Müller Andreas Lienemann Karl-Walter Jauch Martin E. Kreis | 2010 | Surgical Endoscopy2010，，8： | 1 |
| 16 | Cu2Zn Sn S4Thin Film Solar Cells by Fast Coevaporation显示文摘 | Bjrn A S Bjrn M Sonja C | 2011 | Prog Photovolt Res Appl2011，19，1： | 1 |
| 17 | Structural characteristics of new and conventional regenerated cellulosic fibers显示文摘 | Tatjana K Sonja M | 2003 | Textile Res J2003，73，8： | 1 |
| 18 | Characterization of duck leucocytes by monoclonal antibodies显示文摘 | Sonja K Nina K M Beatrice S | 2005 | Devel Comps Immunol2005，29，： | 1 |
| 19 | Distribution of carmabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin显示文摘 | Sonja S Martin S Dieter M | 2005 | J Dermatological Sci2005，38，8： | 1 |
| 20 | Pilot study: peripheral biomarkers for diagnosing sporadic Parkinson’s disease显示文摘 | Edna Grünblatt Sonja Zehetmayer Christian P. Jacob Thomas Müller Wolfgang H. Jost Peter Riederer | 2010 | Journal of Neural Transmission2010，，12： | 1 |
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