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| 1 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 2 | Snedecor, Dynamic treatment model to examine the association between phenotypic drug resis- tance and duration of HIV viral suppression显示文摘 | SONYA J | 2005 | Bulletin of Mathematical Biology2005，67，： | 1 |
| 3 | Morphological differences in BMP-2-induced ectopic bone between solid and crushed hyaluronan hydrogel templates显示文摘 | Gry Hulsart-Billstr?m Sonya Piskounova Lars Gedda Britt-Marie Andersson Kristoffer Bergman J?ns Hilborn Sune Larsson Tim Bowden | 2013 | Journal of Materials Science: Materials in Medicine2013，，5： | 1 |
| 4 | Effect of boron fer-tiliser,weed control and genotype on foliar nutrients and tree growth of ju-venile Pinus radiata at two contrasting sites in New Zealand显示文摘 | OLYKAN SONYA T XUE J M CLINTON P W | 2008 | Forest E-cology and Management2008，225，34： | 1 |
| 5 | Efficient enantioselective extraction tris (diimine) ruthenium (Ⅱ) complexes by chiral,lipophilic TRISPHAT anions显示文摘 | Jérome L Catherine GG Sonya TH | 2000 | Angew Chem2000，39，20： | 1 |
| 6 | Sequence-Selective DNA Cleavage by a Chimeric Metallopeptide显示文摘 | Roger T Kovacic Joel T Welch Sonya J Franklin | 2003 | J Am Chem Soc2003，125，6： | 1 |
| 7 | Systematic Review and Meta‐Analysis of Pharmacological Therapies for Painful Diabetic Peripheral Neuropathy显示文摘 | Snedecor Sonya J Sudharshan Lavanya Cappelleri Joseph C | 2014 | Pain Practice2014，14，2： | 1 |
| 8 | Programmes and principles in treatment of multidrug-resistant tuberculosis显示文摘 | Joia S Mukherjee Michael L Rich Adrienne R Socci J Keith Joseph Felix Alcántara Virú Sonya S Shin Jennifer J Furin Mercedes C Becerra Donna J Barry Jim Yong Kim Jaime Bayona Paul Farmer Mary C Smith Fawzi Kwonjune J Seung | 2004 | The Lancet2004，，9407： | 1 |
| 9 | Test anxiety, past perforrnacc and coping strategies显示文摘 | Robert J E Sonya H | 1986 | Personality and Individual Differences1986，7，2： | 1 |
| 10 | Lanthanide-mediated DNA hydrolysis显示文摘 | Sonya J Franklin | 2001 | Bio-inorganic Chemistry2001，5，： | 1 |
| 11 | Host range and emerging and reemerging Pathogens显示文摘 | Mark E J W Sonya G S | 2005 | Emerg Infec Dis2005，11，12： | 1 |
| 12 | Capsaicin interaction with TRPV1 channels in a lipid bilayer: molecular dynamics simulation显示文摘 | SONYA M H SIMON N KENTON J S | 2015 | Biophysical Journal2015，108，6： | 1 |
| 13 | Intermenstrual bleeding secondary to cesarean scar diverticuli: report of three cases显示文摘 | Sonya S Erickson Bradley J Van Voorhis | 1999 | Obstetrics & Gynecology1999，，5： | 1 |
| 14 | CD8 T-Cell Proliferative Capacity Is Compromised in Primary HIV-1 Infection显示文摘 | Sonya L Heath Steffanie Sabbaj Anju Bansal J Michael Kilby Paul A Goepfert | 2011 | JAIDS Journal of Acquired Immune Deficiency Syndromes2011，，3： | 1 |
| 15 | Female genital schistosomiasis,human papilloma virus infection,and cervical cancer in rural Madagascar:a cross sectional study显示文摘Background Women’s health in resource-limited settings can benefit from the integrated management of high-burden diseases,such as female genital schistosomiasis(FGS)and human papilloma virus(HPV)-related cervical cancer.In schistosomiasis-endemic countries such as Madagascar,data on FGS and HPV prevalence are lacking as well as preventive measures for both conditions.This study aims to estimate the prevalence of FGS and HPV in rural Madagascar,and to examine associated risk factors to identify opportunities for improving women’s health.Methods After initial community outreach activities,interested women aged 18-49 years were recruited consecutively in 2021 at three primary health care centers in the district of Marovoay.FGS was detected by colposcopy.Colposcopy images were double-blind reviewed by two independent specialists.A Luminex bead-based assay was performed on cervical vaginal lavage specimens for HPV typing.Crude(CPR)and adjusted prevalence ratios(APR)of associations between selected factors and FGS and HPV positivity were estimated using univariable and multivariable binary Poisson regression with 95%confidence intervals(CIs).Results Among 500 women enrolled,302 had complete information on FGS and HPV diagnosis,and were thus eligible for analysis.Within the sample,189(62.6%,95%CI:56.9-68.1)cases of FGS were detected.A total of 129 women(42.7%,95%CI:37.1-48.5)tested positive for HPV.In total,80 women(26.5%,95%CI:21.6-31.8)tested positive for both conditions.No association was observed between FGS and HPV positivity,while previous pregnancy(APR=0.65,95%CI:0.43-0.78)and older age(APR=0.59,95%CI:0.42-0.81)are showing a negative association with HPV infection compared to no previous pregnancy and younger age groups.Conclusions The results of the study show that FGS and HPV are highly prevalent in rural Madagascar.The concurrent prevalence of these two conditions requires urgent adaptations of public health strategies to improve women’s health,such as integrated services at primary level of care. | Jean-Marc Kutz Pia Rausche Tahinamandranto Rasamoelina Sonya Ratefiarisoa Ravo Razafindrakoto Philipp Klein Anna Jaeger Rivo Solotiana Rakotomalala Zoly Rakotomalala Bodo Sahondra Randrianasolo Sandrine McKay-Chopin Jürgen May Rapahel Rakotozandrindrainy Dewi Ismajani Puradiredja Elisa Sicuri Monika Hampl Eva Lorenz Tarik Gheit Rivo Andry Rakotoarivelo Daniela Fusco | 2023 | Infectious Diseases of Poverty2023，12，5： | 0 |
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