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| 1 | Expression,deleton and mnutation of ρ16 gene in human gastric cancer显示文摘AIM To investigate the relationship between the expression of p16 gene and the gastric carcinogenesis,depth of invasion and lymph node metastases, and to evaluate the deletion and mutation of exon 2 in p16 gene in gastric carcinoma.METHODS The expression of P16 protein was examined by streptavidin-peroxidase conjugated method (S-P); the deletion and mutation of p16 gene were respectively examined by polymerase chain reaction (PCR) and polymerase chain reaction single-strand conformation polymorphism analysis (PCR-SSCP) in gastric carcinoma.RESULTS Expression of P16 protein was detected in 96.25% (77/80) of the normal gastric mucosa, in 92.00% (45/50) of the dysplastic gastric mucosa and in 47.54% (58/122) of the gastric carcinoma. The positive rate of P16 protein expression in gastric carcinoma was significantly lower than that in normal gastric mucosa and dysplastic gastric mucosa (P<0.05). The positive rate of P16 protein expression in mucoid carcinoma 10.00% (1/ 10) was significantly lower than that in poorly differentiated carcinoma 51.22% ( 21/ 41 ),undifferentiated carcinoma 57.69% (15/26) and signet ring cell carcinoma 62.50% (10/ 16) (P<0.05). The positive rate of p16 protein in 30 cases paired primary and lymph node metastatic gastric carcinoma: There was 46.67% (14/30) in primary gastric carcinoma, 16.67% (5/30) in lymph node metastatic gastric carcinoma. The positive rate of lymph node metastatic carcinoma was significantly lower than that of primary carcinoma (P<0.05). There was of p16 gene mutation in exon 2, but 5 cases displayed deletion of p16 gene in exon 2 in the 25 primary gastric carcinomas.CONCLUSIONS The expression loss of P16 protein related to the gastric carcinogenesis, gastric carcinoma histopathological subtypes and lymph metastasis. The mutation of p16 gene in exon 2 may not be involved in gastric carcinogenesis. But the deletion of p16 gene in exon 2 may be involved in gastric carcinogenesis. | Xiu-Sheng He Qi Su Zhu-Chu Chen Xiu-Tao He Zhi-Feng Long Hui Ling Liang-Run Zhang Oncology Institute,Nanhua University,Hengyang 421001,Hunan Province,ChinaOncology Institute,Center South University,Changsha 410078,Hunan Province,China Department of Gastroenterology,First People’s Hospital of Changde City,Changde 415003,Hunan Province,China | 2001 | World Journal of Gastroenterology2001，7，4： | 40 |
| 2 | Geomorphologic evolution and environmental changes in the Shaluli Mountain region during the Quaternary显示文摘Geologic and geomorphologic evidence from the Shaluli Mountain indicates that the planation surface that formed in the Late Tertiary disintegrated during the Late Pliocene-Early Quaternary. At the same time, rift ba- sins appeared on some parts of the planation surface, and began to accumulate fluvial-lacustrine sediment. These are interpreted as being the response of this region to Phase-A of the Qingzang Tectonic Movement. After this, the Shaluli Mountain continued to rise in several pulses. Faulting and incision by some large tributaries of the Jinsha and Yalong Rivers resulted in several rift river valleys and the earliest terraces. Generally, the planation surface in this region had been uplifted to about 3500—3700 m a.s.l. no later than 550—600 ka BP, after the Kunlun-Huanghe Tectonic Move- ment, and coupled with global glacial climate, and resulted in the earliest glaciation recognized so far in the Hengduan Mountains. At the same time, loess was deposited in the Ganzi area of the northern Shaluli Mountain. During the last glacial period, the Shaluli Mountain approached its present altitude and developed several large ice caps, such as the Daocheng Ice Cap and Xinlong Ice Cap, as well as several huge valley glaciers. These paleoglaciers produced some of the most spectacular glacial topography on the Tibetan Pla- teau. | ZHOU Shangzhe1,2, XU Liubing1, CUI Jianxin1, ZHANG Xiaowei1 & ZHAO Jingdong1 1. National Laboratory of Western China’s Environmental Systems of Ministry of Education of China and Department of Geography, Lan- zhou University, Lanzhou 730000, China 2. Department of Geography, South China Normal University, Guang- zhou 510631, China | 2005 | Chinese Science Bulletin2005，50，1： | 25 |
| 3 | The results and prognosis of different treatment modalities for solitary metastatic lung tumor from nasopharyngeal carcinoma:a retrospective study of 105 cases显示文摘Background and Objective:Nasopharyngeal carcinoma (NPC) is known for its propensity for distant metastases.Lung metastasis is one of the most important causes of death for patients with NPC.Solitary metastatic lung tumor from NPC is a distinctive group associated with a better survival.This study was to find a more effective treatment modality and prognostic factors for the group.Methods:Clinical data of 105 cases of solitary metastatic lung tumor from NPC were retrospectively analyzed.Survival rate was calculated by the Kaplan-Meier method.The difference of survival between the patients treated by different modalities was evaluated by the log-rank test.The Cox univariate and multivariate analyses of gender, age, pathologic type, stage, adjuvant chemotherapy, evaluation of treatment for NPC, disease-free interval, size of metastatic tumor, pulmonary hilar and/or mediastinal lymph node metastasis, treatment modalities, recurrent distant metastases and/or relapse of NPC were conducted.Results:The local control rate was 53.8% in chemotherapy group, 88.0% in radiotherapy +/-chemotherapy group, and 96.4% in operation +/-chemotherapy group (P<0.01).The most promising progression-free survival (PFS) and overall survival (OS) were obtained with operation +/-chemotherapy and followed by radiotherapy +/-chemotherapy.Both of them showed much better efficacy than chemotherapy (P<0.001).The Cox multivariate analysis showed that recurrent distant metastases and/or relapse of NPC affected the survival (OR=2.087, 95% CI=1.277-3.410, P=0.003).The T stage of NPC, size of metastatic tumor, hilar and/or mediastinal lymph node metastasis, and the treatment modality were independent prognostic factors.Conclusions:Operation +/-chemotherapy and radiotherapy +/-chemotherapy are better treatment of solitary metastatic lung tumor from NPC, which could improve the local control and prolong the PFS and OS.Chemotherapy is recommended for patients with higher T stage of NPC, size of metastatic tumor ≥3 cm, pulmonary hilar and/or mediastinal lymph node metastasis. | Jun Ma1,2, Zhe-Sheng Wen1,2, Peng Lin1,2, Xin Wang1,2, Fang-Yun Xie1,3 1 State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P.R.China 2 Department of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R.China 3 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R.China Department of Thoracic Surgery, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi 030012, P.R.China | 2010 | Chinese Journal of Cancer2010，29，9： | 9 |
| 4 | Holocene climate variation denoted by Barkol Lake sediments in northeastern Xinjiang and its possible linkage to the high and low latitude climates显示文摘The climate over the closed inland Barkol Lake,which is located in northeastern Xinjiang Uygur Autonomous Region,is significantly influenced by westerly winds today.To improve our understanding of past climate processes in westerly wind influenced regions in northwestern China,a 250-cm sediment section was retrieved from this lake.After taking the carbon reservoir effect into consideration,the chronological sequence of this section was reconstructed based on seven conventional radiocarbon dates of bulk samples,and the bottom age of this section was determined to be about 9400 cal a BP.Multi-proxy datasets,includingδ18O car,δ13C car of authigenic carbonate,and total organic carbon were examined using wavelet analysis and singular spectrum analysis methods.Results show that the Holocene in the Barkol Lake region can be divided into four stages:(1) a cold and dry early stage before~8000 cal a BP;(2) a moderately warm and wet middle stage between~8000 and 6000 cal a BP;(3) a warm and dry stage,along with a cooling-wetting tendency from 6000 to 2700 cal a BP;and(4) a fluctuating cooling and wet stage between 2700-800 cal a BP,and a drier stage since 800 cal a BP.The general trend of Holocene climatic changes revealed by Barkol Lake sediments was in agreement with that of adjacent regions.We infer that climatic changes during the Holocene in the Barkol Lake region were influenced not only by high latitudes,especially the North Atlantic region climate,but also tropical low-latitude processes,such as the El Nio/La Nia-Southern Oscillation.This study demonstrates that the enhanced activities of ENSO may have played an important role in climatic changes in northeastern Xinjiang during the Holocene.Our results also suggest that climatic patterns may be temporally different in the northern Xinjiang area in response to the changing predominant control of either the Westerly or the Asian summer monsoon,depending on the contrast of their relative strengths. | XUE JiBin & ZHONG Wei 1 School of Geography,South China Normal University,Guangzhou 510631,China 2 Key Laboratory of Oasis Ecology(Ministry of Education) ,Xinjiang University,Urumqi 830046,China 3 Key Laboratory of Western China’s Environmental Systems(Ministry of Education) ,Lanzhou University,Lanzhou 730000,China | 2011 | Science China Earth Sciences2011，54，4： | 8 |
| 5 | Representation of Congruences on Regular Semigroups with Inverse Transversals | Limin Wang Xilin Tang Department of Mathematics, South China Normal University, Guangzhou 510631, P. R. China Department of Mathematics, Guangzhou Teacher’s College, Guangzhou 510400, P. R. China | 1999 | Acta Mathematica Sinica,English Series1999，15，3： | 7 |
| 6 | CT-guided needle biopsy through mandibular area for the diagnosis of nasopharyngeal carcinoma in the parapharyngeal space显示文摘Background and Objective: The primary submucous type of nasopharyngeal carcinoma (NPC) or the recurrent NPC in the parapharyngeal space is difficult to be diagnosed histologically by conventional biopsy because of the obstruction of the surrounding structures. This study was performed to evaluate the needle biopsy approach through the madibular area into the parapharyngeal space under the guidance of computed tomography (CT) for NPC. Methods: Between July 6, 2005 and October 23, 2009, a total of 6 patients were enrolled into the study. Two patients with cervical lymph node metastasis were clinically suspicious of NPC according to their clinical manifestations. However, no cancer cell could be found by repeated nasopharyngeal biopsies followed by histologic examinations. The other 4 patients were diagnosed with recurrent NPCs by magnetic resonance imaging (MRI) or/and positron emission tomography (PET)-CT scan, showing tumors in the parapharyngeal spaces in 3 patients and enlarged retropharyngeal lymph node in 1 patient. The CT-guided puncture was performed through the mandibular skin and the cutting needle biopsy was taken at the parapharyngeal space focus. Results: All the cutting needle biopsies of projected locations have been performed safely. Finally, all the 7 specimens met the requirement of pathologic diagnosis and the cases were all confirmed histologically to be NPCs. The main complication was mild ache at the puncture point. No blood vessel or nerve was injured and no patient needed special treatment. Conclusions: The CT-guided puncture biopsy of the parapharyngeal space through the mandibular area is simple and feasible. It can be an additional option for routine nasopharyngeal biopsy. | Yong Su1,2, Chong Zhao1,2, Wen-Jie Li1,2, Xue-Ying Deng1,3, Rui-Fang Zeng1,2, Nian-Ji Cui1,2, Tai-Xiang Lu1,2 1 State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China 2 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China 3 Department of Radiotherapy, Dongguan People’s Hospital, Dongguan, Guangdong 523000, P. R. China | 2010 | Chinese Journal of Cancer2010，29，8： | 5 |
| 7 | New Development of China-Russia-India Triangle显示文摘Since 2001, positive improvement has occurred in the trianglerelationship between China, Russia and India. The foreignministers of the three nations met in Russia recently, symbolizingthe launching of substantive triangular cooperation. | Ma Jiali is Research Professor at CICIR. He specializes in South Asian security, especially in India’s foreign policy. He is the author of three books, such as Pay Close Attention to India: A Rising Power which is very influential. He was one of the delegates for Track Two Dialogue between China and India for all of four rounds and a delegate for Track Two Dialogue between China, Russia and India. He is also a member of Eminent Persons Group Forum between China and India. | 2005 | Contemporary International Relations2005，15，7： | 4 |
| 8 | Effects of Delayed Second Cochlear Implant显示文摘Objective Since Helms' successful bilateral cochlear implantation with good results in 1996, there have been increasing number of reports on bilateral cochlear implantation. Most second device have been implantated within one year after the first. Considering effects of long time auditory deprivation, it is not clear whether a delayed second cochlear implant serves to add additional benefits and how it may interact with central nervous system plasticity. Methods Three cases who received delayed second cochlear implants at People's Hospital of Peking University from 2002 to 2005 were reviewed. The interval between the first and second implants was longer than 2 years in all three patients. Sound perception, and unilateral/bilateral speech discrimination in quiet and noise were evaluated. In addition, GAP detection test was conducted in one patient. Results In one case, having both implants on provided improved performance compared to using only one implant both in quiet and noise. Presumably due to visual interference from lip-reading or short interval between second implant and testing, one patient showed no improvement from using the second implant either in quiet or noise, while the last case demonstrated additional benefits from the second implant only in quiet. In all three patients, performance in recognizing the four tones in Mandarin was superior over word recognition. Conclusions Considerable plasticity in the cerebral auditory center is preserved, despite long acoustic deprivation in some children who have received unilateral cochlear implant. Delayed second implants can result in significant improvements in some of these children. Visual interference from lip-reading may be an obstacle during retraining. The better recognition of tones in the Mandarin language may represent a different sound discrimination mechanism in the auditory system, although it may also be related to the signal processing mechanisms of the implant used (MED-EL COMBI 40+). | XIA Rui-ming1, WU Xi-hong2, JANG Zi-gang1, JING Yuan-yuan1, LIN Yun-juan1, YU Li-sheng1 1. Department of Otolaryngology, People’s Hospital, Peking University, P. R. China 11, Xizhimen South St, 100044 Beijing, P.R. China 2. Speech and Hearing Research Center, Peking University, China R.M. Xia, X.H. Wu, Z.G. Jang, Y.Y. Jing, Y.J. Lin, L.S.Yu | 2006 | Journal of Otology2006，1，2： | 2 |
| 9 | Developing reliable, repeatable, and accessible methods to provide high-resolution estimates of fish- ing-effort distributions from vessel monitoring system (VMS) data 显示文摘 | Lee J South A B Jennings S | 2010 | Ices Journal of Marine Science Journal Du Conseil2010，67，6： | 1 |
| 10 | The relationship between executive functioning, central coherence, and repetitive behaviors in the high-functioning autism spectrum 显示文摘 | South M Ozonoff S McMahon WM | 2007 | Autism2007，11，5： | 1 |
| 11 | Housing discrimination and residen- tial mobility: Impacts for blacks and whites 显示文摘 | South S J Crowder K D | 1998 | Population Re- search and Policy Review1998，17，4： | 1 |
| 12 | On the dynamic prop- agation of an anti-plane shear crack in a functionally graded piezoelectric strip 显示文摘 | WON S M WON C SOUTH K | 2004 | Acta Mechanica2004，167，： | 1 |
| 13 | Developing reliable,repeatable,and accessible methods to provide high-resolution estimates of fishing-effort distributions from vessel monitoring system(VMS)data显示文摘 | Lee J South A B Jennings S | 2010 | ICES Journal of Marine Science:Journal du Conseil2010，67，6： | 1 |
| 14 | Repetitive behavior profiles in Asperger syndrome and high-functioning autism显示文摘 | South M Ozonoff S Mc Mahon WM | 2005 | J Autism Dev Disord2005，35，2： | 1 |
| 15 | Housework imnarital and nonmarital households 显示文摘 | SOUTH S SPITZE O | 1994 | American sociological review1994，59，： | 1 |
| 16 | Sociodemographic Status, Parental Background, Childhood Family Structure, and Attitudes Toward Family Formation显示文摘 | Trent K South S J | 1992 | Journal of Marriage and the Family1992，54，： | 1 |
| 17 | Combining free text and structured electronic medical record entries to detect acute respira- tory infections显示文摘 | DeLisle S South B Anthony J A etc | 2010 | MEDLINE2010，5，13： | 1 |
| 18 | On the dynamic of an anti-plane shear crack in a graded piezoelectric strip 显示文摘 | WON S M propagation functionally Mechanica WON C SOUTH K | 2004 | Acta2004，167，： | 1 |
| 19 | Differential impact of age,sex steroid hormones,and obesity on basalversus pulsatile growth hormone secretion in men as assessed inan ultrasensitive chemiluminescence assay显示文摘 | VELDHUIS J D LIEM A Y SOUTH S | 1995 | J Clin Endocrinol Metab1995，80，： | 1 |
| 20 | Applied Climatology: Urban Climatology 显示文摘 | South C Grimmond S | 2006 | Progress Physics Geography2006，，30： | 1 |
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