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| 1 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 2 | The nature and formation of the spermatophore and sperm plug in Carcinus maenas 显示文摘 | Spalding J F | 1942 | Quarterly Journal of Microscopical Science1942，83，： | 1 |
| 3 | Mode S-the future显示文摘 | SPALDING D J | 2002 | IEEE Aviation Surveillance Systems2002，1，2： | 1 |
| 4 | Controlling nitrate leaching in irrigated agriculture显示文摘 | Spalding R F Watts D G Schepers J S | 2001 | Journal of Environmental Quality2001，30，： | 1 |
| 5 | Mode S-the future显示文摘 | Spalding D J | 2002 | Aviation Surveillance Systems2002，，： | 1 |
| 6 | Marine ecoregions of the world:a bioregionalization of coastal and shelf areas显示文摘 | Spalding MD Fox HE Allen GR Davidson N Ferdafia ZA Finlayson M Halpern BS Jorge MA Lombana AL Lourie SA Martin KD Manus EC Molnar J Recchia CA Robertson J | | 0，，： | 1 |
| 7 | Evaluation of transgenic mouse bioassays for identifying carcinogens and noncarcinogens显示文摘 | TENNANT RW SPALDING J FRENCH JE | 1996 | Mutat Res1996，365，123： | 1 |
| 8 | Orbital inflammation in Ig G4-related sclerosing disease显示文摘 | Pasquali T Schoenfield L Spalding S J | 2011 | Orbit2011，30，5： | 1 |
| 9 | Controlling Nitrate Leaching in Irrigated Agriculture显示文摘 | SPALDING R F WALTTS D G SCHEPERS J S | 2001 | Journal of Environmental Quality2001，30，78： | 1 |
| 10 | Prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on chemicals by national-toxicology-program 显示文摘 | Temant R W Spalding J Stasiewicz S | 1990 | Mutagenesis1990，5，： | 1 |
| 11 | Real-time reverse transcriptase-polymerase chain reaction detection and analysis of nucleotide sequences coding for a neutralizing epitope on infectious bursal disease viruses 显示文摘 | Jackwood D J Spalding B D Sommer S E | 2003 | Avian Dis2003，47，： | 1 |
| 12 | Shock initiation of crystalline boron in oxygen and fluorine compounds显示文摘 | Krier H Burton R L Pirman S R Spalding M J | | 0，，： | 1 |
| 13 | Real-time reverse transcriptase-polymerase chain reaction detection and analysis of nucleotide sequences coding for a neutralizing epitope on infectious bursal disease viruses显示文摘 | Jackwood D J Spalding B D Sommer S E | 2003 | Avian Diseases2003，47，： | 1 |
| 14 | Glucagon is a primany controller of hepatic glycogenolysis and gluconeogenesis during muscular work显示文摘 | Wasserman D H Spalding J A Lacy D B | 1989 | Am J Physiol1989，257，11： | 1 |
| 15 | Iron and infection:the heart of the matter 显示文摘 | Bullen J J Rogers H J Spalding PB | 2005 | FEMS lmmunol Med Microbiol2005，43，2： | 1 |
| 16 | Cancer immunoconjugates:will clinical successlead to commercial success?显示文摘 | Spalding B J | 1991 | Bio/Technology1991，9，： | 1 |
| 17 | Potentially mineralizable nitrogen and nitrate leaching under different land-use condition Western Nebraska 显示文摘 | Saint R Schepers J S Spalding R F | 1991 | Journal of Environmental Science and Health1991，26，3： | 1 |
| 18 | Measuring the extent and effectiveness of protected areas as an indicator for meeting global biodiversity targets 显示文摘 | Chape S Harrison J Spalding M | 2005 | Philosophical Transac- tions of the Royal Society B: Biological Sciences2005，360，1454： | 1 |
| 19 | Sources and concentrations of ni- trate-nitrogen in ground water of the Central Platte Region, Nebraska显示文摘 | Gormly J R Spalding R F | 1979 | Ground Water1979，17，3： | 1 |
| 20 | A two - fluid model of turbulence and its application to near - wall flows 显示文摘 | O J Ilegbusi D B Spalding | 1987 | Physicochemical Hydrodynamics1987，9，12： | 1 |
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