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| 1 | Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy显示文摘AIM: To investigate plasma ghrelin, gastrin and growth hormone secretagogue receptor (GHS-R) expression in advanced gastric cancer (GC) before and after resection. METHODS: Seventy subjects in whom endoscopy of the upper gastrointestinal tract was performed in the Department of General Surgery at Cracow University during the past decade: (1) 25 patients with GC associated with Helicobacter pylori (H. pylori) infection; (2) 10 patients with GC 4-5 years after (total or subtotal) gastrectomy; (3) 25 healthy H. pylori-negative controls, matched by age and BMI to the above two groups; and (4) 10 GC patients 4-5 years after total gastrectomy. Ghrelin and gastrin plasma concentrations were measured by specific radioimmunoassay under fasting conditions and postprandially at 60 and 90 min after ingestion of a mixed meal. GHS-R expression was examined in biopsy samples from intact healthy mucosa and GC tissue using semi-quantitative reverse transcription-polymerase chain reaction. RESULTS: In healthy controls, fasting plasma ghrelin levels were significantly elevated and declined markedly at 60 and 90 min after a mixed meal. The concomitant enhanced ghrelin, GHS-R and gastrin expression in GC tissue over that recorded in intact mucosa, and the marked rise in plasma gastrin in these subjects under fasting conditions indicate the role of these hormonal factors in GC formation. Fasting plasma levels and postprandial response of ghrelin and gastrin appear to be inversely correlated in healthy subjects. Feeding in the controls resulted in a significant fall in plasma ghrelin with a subsequent rise in plasma gastrin, but in H. pylori-positive GC patients submitted to total or distal gastrectomy, feeding failed to affect significantly the fall in plasma ghrelin that was recorded in these patients before surgery. Fasting ghrelin concentrations were significantly lower in patients 4-5 years after total gastrectomy compared to those in healthy controls and to these in GC patients before surgery. CONCLUSION: Elevated plasma gastrin and suppression of fasting ghrelin in patients with GC suggest the existence of a close relationship between these two hormones in gastric carcinogenesis. | Anna Zub-Pokrowiecka Kazimierz Rembiasz Peter C Konturek Andrzej Budzyński Stanisaw J Konturek Marek Winiarski Wadysaw Bielański | 2011 | World Journal of Gastroenterology2011，17，4： | 7 |
| 2 | The use of acellular dermal allograft for vulvovaginal reconstruction 显示文摘 | Stany MP Sunde J Bidus MA | 2010 | Int J Gynecol Cancer2010，20，6： | 1 |
| 3 | The use of acellular dermal graft for vulvovaginal reconstruction in a patient with lichen planus显示文摘 | STANY M P WINTER W E ELKAS J C | 2005 | Obstet Gynecol2005，105，52： | 1 |
| 4 | comparative evaluation of seven cell collection devices for cervical smears 显示文摘 | Kohlberger PD Stani J Gitsch G | 1999 | Acta Cytol1999，43，6： | 1 |
| 5 | The use of the heteropoly acids, H5PMo10V2O40, H7 or H12 , in the anode catalyst layer of a proton exchange membrane fuel cell 显示文摘 | Kuo M C Limoges B R Stanis R J | 2007 | J Power Sources2007，171，2： | 1 |
| 6 | The Use of Acellular Der- mal Allograft for Vulvovaginal Reconstruction显示文摘 | Stany MP Sunde J Bidus MA | 2010 | Int J Gynecol Cancer2010，20，： | 1 |
| 7 | Comparative evaluation of seven cell collection devices for cervical smears显示文摘 | Kohlberger PD Stani J Gitsch G | 1999 | Act Citole1999，43，9： | 1 |
| 8 | The use of acellular dermal al- lograft for vulvovaginal reconstruction 显示文摘 | Stany MP Sunde J Bidus MA | 2010 | Int J Gynecol2010，20，6： | 1 |
| 9 | Evaluation of the United States Food and Drug Administration-approved scoring and test system of HER-2 protein expression in breast cancer显示文摘 | Oberhuber G Stani J | 2001 | Clin Cancer Res2001，7，6： | 1 |
| 10 | In vivo immu-nomodulation by the neuropeptide substance P 显示文摘 | Seieehitano R Biennenstoek J Stanis AM | 1998 | Inununolgy1998，63，4： | 1 |
| 11 | Comparative evaluation of seven cell collection devices for cervical smears显示文摘 | Kohlberger PD Stani J Gitsch G | 1999 | Acta Cytol1999，43，： | 1 |
| 12 | Theuse of accUular for vulvo vaginal reconstruction显示文摘 | Stany MP Sunde J Bidus MA | 2010 | Int J Gynecol Cancer2010，20，6： | 1 |
| 13 | 25 - year experience with 456 combined mitral and aortic valve re - placement for rheumatic heart disease 显示文摘 | Stani EY J Edwin R Colin N J | 2000 | Ann Thorac Surg2000，69，4： | 1 |
| 14 | The prevalence of HR-HPV DNA in ASC-US Pap smears:A military population study显示文摘 | Stany MP Bidus MA Reed E J | 2006 | Gynecol Oncol2006，101，1： | 1 |
| 15 | Experiences with the dual digestion of municipal sewage sludge 显示文摘 | BOROWAKI S STANIS J AW SZOPA | 2007 | Bioresource Technology2007，98，6： | 1 |
| 16 | Evaluation of the United States Food and Drug Administration-approved scoring and test system of HER-2protein expression in breast cancer显示文摘 | Birner P Oberhuber G Stani J | 2001 | Clin Cancer Res2001，7，： | 1 |
| 17 | Evaluation of the united states food and drug administration-approved scoring and test system of HER-2 protein expression in breast cancer显示文摘 | Birner P Oberhuber G Stani J | 2001 | Clin Cancer Res2001，7，6： | 1 |
| 18 | Evaluation of the United States Food and Drug Administration-approved scoring and test system of HER-2 protein expression in breast cancer显示文摘 | BIRNER P OBERHUBER G STANI J | 2001 | Clin Cancer Res2001，7，6： | 1 |
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