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| 1 | Effects of Taxotere on invasive potential and multidrug resistance phenotype in pancreatic carcinoma cell line SUIT-2显示文摘INTRODUCTIONDevelopment of drug-resistance to chemotherapyand subsequent metastasis of tumor are primarilyresponsible for treatment failure and the death fromcancer. There have been many previous studies onthe relationship between expression of multidrugresistance (MDR) phenotype P-glycoprotein (P-gp)and the malignant properties of tumors, but theresults are often conflicting[1-8]. The difference intumor types or MDR phenotype induced by specificagents might account for this discrepancy. Taxotere(TXT), a member of the family of taxanes, hasantitumor activity through its effect of promotingthe polymerization of tubulin[9,10]. | Edgar Staren Takeshi Iwamura Hubert Appert John Howard | 2001 | World Journal of Gastroenterology2001，7，1： | 12 |
| 2 | Taxotere resistance in SUIT Taxotere resistance in pancreatic carcinoma cell line SUIT 2 and its sublines显示文摘AIM: To investigate the specific mechanisms of intrinsic and acquired resistance to taxotere (TXT) in pancreatic adenocarcinoma (PAC).METHODS: MTT assay was used to detect the sensitivity of PAC cell line SUIT-2 and its sublines (S-007, S-013, S-020,S-028 and TXT selected SUIT-2 cell line, S2/TXT) to TXT.Mdr1 (P-gp), multidrug resistance associated protein (MRP), lung resistance protein (LRP) and β-tubulin isotype gene expressions were detected by RT-PCR. The functionality of P-gp and MRP was tested using their specific blocker verapamil ( Ver ) and indomethacin ( IMC ),respectively. The transporter activity of P-gp was also confirmed by Rhodamine 123 accumulation assay.RESULTS: S-020 and S2/TXT were found to be significantly resistant to TXT(19 and 9.5-fold to their parental cell line SUIT-2, respectively ). RT-PCR demonstrated strong expression of Mdr1 in these two cell lines, but weaker expression or no expression in other cells lines. MRP and LRP expressions were found in most of these cell lines. The TXT-resistance in S2-020 and S2/TXT could be reversed almost completely by Ver, but not by IMC. Flow cytometry showed that Ver increased the accumulation of Rhodamine-123 in these two cell lines. Compared with S-020 and SUIT-2,the levels of β-tubulin isotype II, III expreesions in S-2/TXTwere increased remarkably.CONCLUSION: The both intrinsic and acquired TXT-related drugresistance in these PAC cell lines is mainly mediated by P-gp, but had no relationship to MRP and LRP expressions.The increases of β-tubulin isotype II, III might be collateral changes that occur when the SUIT-2 cells are treated with TXT. | Edgar Staren Takeshi lwamura HubertAppert JohnHoward | 2001 | World Journal of Gastroenterology2001，7，6： | 7 |
| 3 | Intraoperative ultrasound in the management of liver neoplasms 显示文摘 | Staren ED Gambla M Deziel DJ | 1997 | Am Surg1997，63，： | 1 |
| 4 | Ultrasound in head and neck surgery:thyroid,parathyroid,and cervical lymph nodes显示文摘 | Senchenkov A Staren ED | 2004 | Surg Clin North Am2004，84，4： | 1 |
| 5 | Patellar height on sagittal MR imaging of the knee显示文摘 | Miller TT Staren RB Feldman F | 1996 | AJR1996，167，2： | 1 |
| 6 | INVASIVE THERAPY OF METASTATIC COLORECTAL CANCER TO THE LIVER显示文摘 | Keith W. Millikan Edgar D. Staren Alexander Doolas | 1997 | Surgical Clinics of North America1997，，1： | 1 |
| 7 | Breastultrasound显示文摘 | STARENED O'NEILLTP | 1998 | SurgClinNorthAmer1998，73，2： | 1 |
| 8 | Neuroendocrine carcinomas of the stomach: a clinicopathologic evaluation 显示文摘 | Staren ED Lott S Saavedra VM | 1992 | Surgery1992，112，6： | 1 |
| 9 | Neuroendocrine cancers of the colon and rectum 显示文摘 | SACLARIDES T J SZELUGA D STAREN ED | 1994 | Dis Colon Rectum1994，37，7： | 1 |
| 10 | Thyroid reoperations:indications and risks显示文摘 | Wilson DB Staren ED Prina RA | 1998 | Am Surg1998，64，7： | 1 |
| 11 | Breast ultrasound显示文摘 | O' Neill TP | 1998 | Surg Clin North Am1998，78，2： | 1 |
| 12 | Ultrasound in head and neck surgery: thyroid, parathyroid, and cervical lymph nodes 显示文摘 | Senchenkov A Staren ED | 2004 | Surg Clin North Am2004，84，4： | 1 |
| 13 | Ultrasound in head and neck sui^ery :thyroid,parathyroid,and cervical lymph nodes 显示文摘 | Senchenkov A Staren ED | 2004 | Surg Clin North Am2004，84，4： | 1 |
| 14 | Use of fine-needle aspiration biopsy and frozen section in the mamagement of the solitary thyroid nodule显示文摘 | Sabel MS Staren ED Gianakakis LM | 1997 | Surgery1997，122，6： | 1 |
| 15 | Adrenalectomy in the era of laparoscopy显示文摘 | Staren ED Prinz RA | 1996 | Surgery1996，120，： | 1 |
| 16 | Neuroendocrine carcinomas of the colon and rectum:a clinicopathologic evaluation显示文摘 | Staren ED Gould VE Warren WH | 1988 | Surgery1988，104，6： | 1 |
| 17 | Mechanisms of toxotere-related drug resistance in pancreatic carcinoma显示文摘 | Liu B Staren E D Iwamura T | 2001 | J Surg Res2001，99，2： | 1 |
| 18 | Breast ultrasound显示文摘 | Staren ED O'Neill TP | 1998 | Surg Clin North AM1998，78，2： | 1 |
| 19 | Cryosurgery of breast cancer 显示文摘 | Sabel MS Gianakis LM | 1997 | Arch Surg1997，132，1： | 1 |
| 20 | Matrix metalloproteinase expression in breast cancer显示文摘 | Bartsch JE Staren ED Appert HE | 2003 | J Surg Res2003，110，2： | 1 |
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