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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Bogatyrev:Immunogenic Properties of Colloidal Gold, Russian Academy of Sciences显示文摘 | DYKMAN L A SUMAROKA M V STAROVEROV S A | 2004 | January2004，31，1： | 1 |
| 3 | A strategy for the generation of non-aggregating mutants of Anthozoa fluorescent proteins 显示文摘 | Yanushevich Y G Staroverov D B Savitsky A P | 2002 | FEBS Lett2002，511，： | 1 |
| 4 | New chiral stationary phase with macrocyclic glycopeptide antibiotic eremomycin chemlcally bonded to silica显示文摘 | Staroverov S M Kuznetsov M A Nesterenko P N | 2006 | J Chroma A2006，1108，2： | 1 |
| 5 | Engineering of a monomericgreen-to-red photoactivatable fluorescent protein inducedby blue light 显示文摘 | Gurskaya N G Verkhusha V V Shcheglov A S Staroverov D B Chepurnykh T V Fradkov A F Luky-anov S Lukyanov K A | 2006 | Nature Biotechnology2006，24，4： | 1 |
| 6 | HPLC analysis of flavonoids: determining rutin in plant extracts显示文摘 | Deineka V I Grigor'ev A M Staroverov V M | 2004 | Pharmaceutical Chemistry Journal2004，38，9： | 1 |
| 7 | Immunogenic properties of the colloidal gold显示文摘 | DYKMAN L A SUMAROKA M V STAROVEROV S A | 2004 | Izv Akad Nauk Ser Biol2004，，1： | 1 |
| 8 | Climbing the density functional ladder:nonempirical Meta-Generalized Gradient Approximation de-signed for molecules and solids显示文摘 | Tao J Perdew J P Staroverov V N | 2003 | Phys Hev Lett2003，91，14： | 1 |
| 9 | A strategy for the generation of non-aggregating mutants of Anthozoa fluorescent proterins显示文摘 | Yanushevich YG Staroverov DB Savitsky AP | 2002 | FEBS Lett2002，511，13： | 1 |
| 10 | A strategy for the generation of non-aggregating mutants of A nthozoa fluoresceltt proteins显示文摘 | Yanushevich Y G Staroverov D B Savitsky A P et ol | 2002 | FEBS Lett2002，511，： | 1 |
| 11 | Climbing the density dunctional ladder:nonempirical meta-generalized gradient approximation designed molecules and solids显示文摘 | TAO J PERDEW J P STAROVEROV V N | | 0，，14： | 1 |
| 12 | Bogatyrev Immunogenic Properties of Colloidal Gold显示文摘 | DYKMAN L A SUMAROKA M V STAROVEROV S A | 2004 | Russian Academy of Sciences2004，1，31： | 1 |
| 13 | Is the hydrogen bond in water dimer and ice covalent?显示文摘 | GHANTY T K STAROVEROV V N KOREN P R | 2000 | J Am Chem Soc2000，122，6： | 1 |
| 14 | A strategy for the generation of non-aggregating mutants of An- thozoa fluorescent proteins显示文摘 | Yanushevich Y G Staroverov D B Savitsky A P | 2002 | FEBS Letter2002，511，： | 1 |
| 15 | Therapeutic angiogenesis in treatment of patients with chronic obliterating diseases of lower limb arteries显示文摘 | Cherviakovu V Staroverov IN Nersesian EG | | 0，，3： | 1 |
| 16 | New chiral stationary phase with macrocyclic glycopeptide antibiotic eremomycin chemically bonded to silica显示文摘 | Kuznetsov MA Nesterenko PN | 2006 | J Chromatography A2006，1108，2： | 1 |
| 17 | New chiral stationary phase with macrocy- clic glycopeptides antibiotic eremomycin chemically bonded to silica 显示文摘 | STAROVEROV S M KUZNETSOV M A NESTEREN- KO P N | 2006 | Journal of Chromatography A2006，1108，： | 1 |
| 18 | Immunigenic properties of colloidal gold显示文摘 | Sumaroka M V Staroverov S A | 2004 | Biol Boll2004，，1： | 1 |
| 19 | Immunogenic Properties of Colloidal Gold 显示文摘 | Dykman LA Sumaroka MV Staroverov SA | 2004 | Biology Bulletin2004，31，1： | 1 |
| 20 | Farred fluorescent tag for protein labeling 显示文摘 | Fradkov AF Verkhusha VV Staroverov DB | 2002 | Biochem J2002，368，1： | 1 |
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