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| 1 | 胆固醇结石病人肝脏胆小管侧膜ATP基因表达差异的研究显示文摘目的:本研究旨在测定比较胆石病人与对照组肝脏胆小管侧膜转运蛋白表达差异,以探讨胆石病发生的分子生物学机制。方法:研究包括20例胆囊胆固醇结石病人和11例无胆石症的对照。测定血清胆固醇和甘油三酯、胆汁胆固醇、胆汁酸和磷脂含量,采用Carey表计算胆汁胆固醇饱和指数。实时定量PCR法测定肝脏胆小管侧膜转运蛋白(ABCG5、ABCG8、ABCBll和ABCB4)mRNA的表达量。结果:胆石组血清胆固醇低于对照组(P<0.05)。胆石组胆汁胆固醇摩尔百分比和胆固醇饱和指数较对照组显著升高(P<0.01)。胆石组肝脏胆小管侧膜胆固醇转运蛋白ABCG5和ABCG8表达高于对照组,且后者差异具有统计学显著性(ABCG5:31.44±3.17Vs25.72±3.27,ABCG8:27.53±3.06vs17.81±2.23)。ABCBll和ABCB4表达在两组间差异无显著性。结论:本研究显示,胆石病主要病理生理异常为胆汁胆固醇过饱和,与肝脏胆小管侧膜胆固醇转运蛋白ABCG5和ABCG8的mRNA表达增加有关。 | 蒋兆彦 韩天权 所广军 袁作彪 姜志宏 商俊 蔡杏兴 Gsta Eggertsen Curt Einarsson 张圣道 | 2005 | 外科理论与实践2005，10，1： | 24 |
| 2 | 胆固醇结石病人肝脏脂质代谢异常的分子生物学研究显示文摘目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。 | 蒋兆彦 姜翀弋 胡海 所广军 Paolo Parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权 张圣道 | 2007 | 外科理论与实践2007，12，5： | 4 |
| 3 | The Genetic Architecture of Multiple Myeloma显示文摘 | Steven M. Prideaux Emma Conway O’Brien Timothy J. Chevassut G?sta Gahrton | 2014 | Advances in Hematology2014，，： | 2 |
| 4 | The infection of clover root hairs by nodule bacteria studied by a simple glass slide technique显示文摘 | G(O)STA F(A)HRAEUS F(A)HRAEUS G | | 0，，： | 1 |
| 5 | Context-aware saliency detection显示文摘 | G Stas Z Lihi Ayellet T | 2012 | IEEE transactions on pattern analysis and machine intelligence2012，34，10： | 1 |
| 6 | Drug-resistant tuberculosis:Past,present,future显示文摘 | Chiang CY Centis R Ba sta Migliori G | 2010 | Respirology2010，15，3： | 1 |
| 7 | Characterization of complex networks: A survey of measurements 显示文摘 | Co sta L da F Rodrigues F A Travieso G | 2007 | Adv Phys2007，56，1： | 1 |
| 8 | Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption显示文摘The etiology of most cases of idiopathic bile acid malabsorption (IBAM) is unknown. In this study, a Swedish family with bile acid malabsorption in three consecutive generations was screened for mutations in the ileal apical sodium-bile acid cotransporter gene (ASBT; gene symbol, SLC10A2) and in the genes for several of the nuclear receptors known to be important for ASBT expression: the farnesoid X receptor (FXR) and peroxisome proliferator activated receptor alpha (PPARa). The patients presented with a clinical history of idiopathic chronic watery diarrhea, which was responsive to cholestyramine treatment and consistent with IBAM. Bile acid absorption was determined using 75Se-homocholic acid taurine (SeHCAT); bile acid synthesis was estimated by measuring the plasma levels of 7a-hydroxy-4-cholesten-3-one (C4). The ASBT, FXR, and PPARa genes in the affected and unaffected family members were analyzed using single stranded conformation polymorphism (SSCP), denaturing HPLC, and direct sequencing. No ASBT mutations were identified and the ASBT gene did not segregate withthe bile acid malabsorption phenotype. Similarly, no mutations or polymorphisms were identified in the FXR or PPARa genes associated with the bile acid malabsorption phenotype. These studies indicate that the intestinal bile acid malabsorption in these patients cannot be attributed to defects in ASBT. In the absence of apparent ileal disease, alternative explanations such as accelerated transit through the small intestine may be responsible for the IBAM. | Marco Montagnani Anna Abrahamsson Cecilia Glman Gsta Eggertsen Hanns-Ulrich Marschall Elisa Ravaioli Curt Einarsson Paul A Dawson | 2006 | World Journal of Gastroenterology2006，12，47： | 1 |
| 9 | Minimally invasive management of urolithiasis显示文摘 | Gayer G Hertz M Sta K | 2006 | Semin Ultrasound CT MR2006，27，2： | 1 |
| 10 | Expression of a fl-defen- sin mRNA, lingual antimicrobial peptide, in bovine mammaryepithelial tissue is induced by mastitis 显示文摘 | KARA S STAS G LAURA G | 2004 | Infect Immun2004，72，12： | 1 |
| 11 | Exchanges across land-water-scape boundaries in urban systems:strategies for reducing nitrate pollution显示文摘 | Cadenasso ML Pickett STA Groffman PM Brush GS Galvin MF Grove JM Hagar G Marshall V McGrath BP O'Neil-Dunne JPM Stack WP Troy AR | | 0，，： | 1 |
| 12 | Functional and morphological characterization of cultures of Kupffer cells and liver endothelial cells prepared by means of density separation in Percoll, and selective substrate adherence显示文摘 | B?rd Smedsr?d H?kan Pertoft G?sta Eggertsen Christer Sundstr?m | 1985 | Cell and Tissue Research1985，，3： | 1 |
| 13 | Hypertension in obesity显示文摘 | Kurukulasuriya L R Stas S Lastra G | 2011 | Med Clin North Am2011，95，5： | 1 |
| 14 | Irritable bowel syndrome and dyspepsia in the general population: Overlap and lack of stability over time显示文摘 | Lars Agréus Kurt Sv?rdsudd Olof Nyrén G?sta Tibblin | 1995 | Gastroenterology1995，，3： | 1 |
| 15 | Progress in al ogeneic transplantation for multiple myelomaEur显示文摘 | Gahrton G?sta | | 0，，04： | 1 |
| 16 | A plssma membrane-bound enzyme of tobacco toots catalyses the formation of nitric oxide from nitrite显示文摘 | STA HR C STRUBE F MARX G | 2001 | Planta2001，212，56： | 1 |
| 17 | Co ntrol centers evolve with agent technology 显示文摘 | Azevedo G P Feijo B Co sta M | 2000 | IEEE Computer Applications in Power2000，13，3： | 1 |
| 18 | Is it possible to compare researchers with different scientific interests? 显示文摘 | BAT CAMPITELI M G KINOUCHI O | 2006 | Scientometrics2006，68，1： | 1 |
| 19 | Plasma exchange and intravenous immunoglobulin treatment of the mother to diminish fetal rhesus hemolytic disease显示文摘 | G(o)sta B Anders S Tomas G | | 0，，： | 1 |
| 20 | Assessment of the chemical,microbiological and toxicological aspects of post-processing water from underground coal gasification显示文摘 | Pankiewicz-Sperka M Stańczyk K Paza G A | 2014 | Ecotoxicol Environ Saf2014，108，： | 1 |
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