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| 1 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 2 | Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia显示文摘AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia(ACN) in colorectal cancer(CRC) screening.METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero(poorest) to six(best). Odds ratios(ORs) and 95%CIs were calculated using multivariable logistic regression to evaluate the association between the single lifestyle variables and the lifestyle score and the probability of detecting ACN.RESULTS: In all 6315 women and men completed the lifestyle questionnaire, 3323(53%) in the FIT arm and 2992(47%) in the FS arm. This was 89% of those who participated in screening. ACN was diagnosed in 311(5%) participants of which 25(8%) were diagnosed with CRC. For individuals with a lifestyle score of two, three, four, and five-six, the ORs(95%CI) for the probability of ACN detection were 0.82(0.45-1.16), 0.43(0.28-0.73), 0.41(0.23-0.64), and 0.41(0.22-0.73), respectively compared to individuals with a lifestyle score of zero-one. Of the single lifestyle factors, adherence to non-smoking and moderate alcohol intake were associated with a decreased probability of ACN detection compared to being a smoker or having a high alcohol intake 0.53(0.42-0.68) and 0.63(0.43-0.93) respectively.CONCLUSION: Adopted healthy behaviors were inversely associated with the probability of ACN detection. Lifestyle assessment might be useful for risk stratification in CRC screening. | Markus D Knudsen Thomas de Lange Edoardo Botteri Dung-Hong Nguyen Helge Evensen Chloé B Steen Geir Hoff Tomm Bernklev Anette Hjartaker Paula Berstad | 2016 | World Journal of Gastroenterology2016，22，27： | 3 |
| 3 | :The effects of trust and interdependence on relationship commitment: A transatlantic study显示文摘 | Geyskens I Steen K B Scheer L K | 1996 | International Journal of Research in Marketing1996，13，4： | 1 |
| 4 | Gelatio-nase B functions as regulator and effector in leukocyte biology 显示文摘 | Opdenakker G Van- den- Steen PE Dubois B | 2001 | Leukoc Biol2001，69，6： | 1 |
| 5 | Insight into the pathophysiology of unstable coronary artery disease显示文摘 | Steen D K Ravn H B Falk E | 1997 | J Am Cardiol1997，80，5： | 1 |
| 6 | Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9) 显示文摘 | VAN DEN STEEN P E DUBOIS B NELISSEN I | 2002 | Crit Rev Biochem Mol Biol2002，37，6： | 1 |
| 7 | Gelatinase B functions as regulator and effector in leukocyte biology 显示文摘 | Opdenakker G Van den steen PE Duhois B | 2001 | J Leukoo Biol2001，69，6： | 1 |
| 8 | Expression of vascular endothelial growth factor(VEGF) in retinoblastoma but not in posterior uveal melanoma显示文摘 | Kvanta A Steen B Seregard S | 1996 | Exp Eye Res1996，63，5： | 1 |
| 9 | Resveratrol in metabolic health: an overview of the current evidence and perspectives显示文摘 | Morten M?ller Poulsen Jens Otto Lunde J?rgensen Niels Jessen Bj?rn Richelsen Steen B?nl?kke Pedersen | 2013 | Ann. N.Y. Acad. Sci2013，，1： | 1 |
| 10 | Parametric sensitivity in first order reliability theory显示文摘 | Peter B Steen K | 1989 | Journal of Engineering Mechanics1989，115，7： | 1 |
| 11 | Delayed inflammation-associated corneal neovascularization in MMP-2-deficient mice显示文摘 | Samolov B Steen B Seregard S | 2005 | Exp Eye Res2005，80，2： | 1 |
| 12 | libifbi: a C++implementation for fast box intersection and application tosparse mass spectrometry data 显示文摘 | KIRCHNERM XU B STEEN H | 2011 | Bioinformatics2011，27，8： | 1 |
| 13 | Open aquaculture engineering:mooring and net pen deployment显示文摘 | Baldwin K Celikkol B Steen R | 2000 | Mar Technol Soc J2000，34，1： | 1 |
| 14 | Matrix metalloproteinase (MMP) expression in experimental choroidal neovascularization 显示文摘 | Kvanta A Shen WY Sarman S Seregard S Steen B Rakoczy E | 2000 | Curr Eye Res2000，21，： | 1 |
| 15 | On uncertainty and sensitivity of LCA based setting显示文摘 | STEEN B | 1997 | Cleaner Prod1997，5，4： | 1 |
| 16 | The Danish emergency response model of the atmosphere (DERMA)显示文摘 | Jens H S Alexander B Steen H | 2007 | Journal of enviromental radioacitivity2007，4，： | 1 |
| 17 | Cesarean delivery and risk of Intesti- nal bacterialinfection 显示文摘 | Peter B Jacob S Steen E | 2010 | J Infect Dis2010，201，3： | 1 |
| 18 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 19 | Volume rendering of 3-D medical ultrasound data using feature mapping显示文摘 | Steen E Olstad B | 1994 | IEEE Transactions Medical Imaging1994，13，3： | 1 |
| 20 | Osteoarthrosis changes of bone cartilage and synorial membrame in relation to bone sitigraphy显示文摘 | STEEN B | 1985 | Acta Orthop Scand1985，56，： | 1 |
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