|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 2 | 酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。 | 陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB | 2021 | 中华高血压杂志2021，29，2： | 9 |
| 3 | Wash water in waterworks:contaminants and process options for reclamation显示文摘Reclamation of clean water from filter backwash water was studied through pilot-scale experiments.The pilot plant consisted of clarification,sand-filtration,and ultrafiltration modules in sequence,with a provision to bypass the sand filter.Clean water that conformed to World Health Organization (WHO) guidelines on Potable Quality was reclaimed.Turbidity,aluminum and iron were found to be critical contaminants in process selection and design.Clarification,followed by sand filtration,was found to be the minimum requirement for recycling filter backwash.However,membrane filtration would enhance reclaimed water quality as the membrane acts as an additional barrier against Giardia and Cryptosporidium. | C B Chidambara Raj Tan Ee Kwong Soh Hoo Tiong Paul Stefan Klose | 2008 | Journal of Environmental Sciences2008，20，11： | 4 |
| 4 | Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and migration显示文摘Parathyroid hormone(PTH) is well-known as the principal regulator of calcium homeostasis in the human body and controls bone metabolism via actions on the survival and activation of osteoblasts. The intermittent administration of PTH has been shown to stimulate bone production in mice and men and therefore PTH administration has been recently approved for the treatment of osteoporosis. Besides to its physiological role in bone remodelling PTH has been demonstrated to influence and expand the bone marrow stem cell niche where hematopoietic stem cells, capable of both self-renewal and differentiation, reside. Moreover, intermittent PTH treatment is capable to induce mobilization of progenitor cells from the bone marrow into the bloodstream. This novel function of PTH on modulating the activity of the stem cell niche in the bone marrow as well as on mobilization and regeneration of bone marrow-derived stem cells offers new therapeutic options in bone marrow and stem cell transplantation as well as in the field of ischemic disorders. | Bruno C Huber Ulrich Grabmaier Stefan Brunner | 2014 | World Journal of Stem Cells2014，6，5： | 4 |
| 5 | Characterisation of human non-proliferative diabetic retinopathy using the fractal analysis显示文摘· AIM: To investigate and quantify changes in the branching patterns of the retina vascular network in diabetes using the fractal analysis method.·METHODS: This was a clinic-based prospective study of 172 participants managed at the Ophthalmological Clinic of Cluj-Napoca, Romania, between January 2012 and December 2013. A set of 172 segmented and skeletonized human retinal images, corresponding to both normal(24 images) and pathological(148 images)states of the retina were examined. An automatic unsupervised method for retinal vessel segmentation was applied before fractal analysis. The fractal analyses of the retinal digital images were performed using the fractal analysis software Image J. Statistical analyses were performed for these groups using Microsoft Office Excel2003 and Graph Pad In Stat software.·RESULTS: It was found that subtle changes in the vascular network geometry of the human retina are influenced by diabetic retinopathy(DR) and can be estimated using the fractal geometry. The average of fractal dimensions D for the normal images(segmented and skeletonized versions) is slightly lower than the corresponding values of mild non-proliferative DR(NPDR) images(segmented and skeletonized versions).The average of fractal dimensions D for the normal images(segmented and skeletonized versions) is higher than the corresponding values of moderate NPDR images(segmented and skeletonized versions). The lowestvalues were found for the corresponding values of severe NPDR images(segmented and skeletonized versions).· CONCLUSION: The fractal analysis of fundus photographs may be used for a more complete understanding of the early and basic pathophysiological mechanisms of diabetes. The architecture of the retinal microvasculature in diabetes can be quantitative quantified by means of the fractal dimension.Microvascular abnormalities on retinal imaging may elucidate early mechanistic pathways for microvascular complications and distinguish patients with DR from healthy individuals. | Stefan Tǎlu Dan Mihai Cǎlugǎru Carmen Alina Lupascu | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 4 |
| 6 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 7 | Diagnosis of renal vascular disease with MR angiography显示文摘 | QIAN D O N G STEFAN O S Ruth C C | 1999 | Radiographics1999，19，6： | 2 |
| 8 | A modular DNA signal translator for the controlled release of a protein by an aptamer显示文摘 | Stefan Beyer Friedrich C Simmel | 2006 | Nucleic Acids Research2006，34，5： | 1 |
| 9 | Magnetoencephalography 显示文摘 | Hummel C Stefan H | 1997 | Epilepsia1997，38，10： | 1 |
| 10 | Cataract surgery and postoperative endophthalmitis显示文摘 | Stefan C Anghel GH Tebeanu E | | 0，，03： | 1 |
| 11 | Comprehensive Identification of Proteins from MALDI Imaging显示文摘 | Stefan K. Maier Hannes Hahne Amin Moghaddas Gholami Benjamin Balluff Stephan Meding Cédrik Schoene Axel K. Walch Bernhard Kuster | 2013 | Molecular & Cellular Proteomics2013，，10： | 1 |
| 12 | Structural and immunohistoehemieal changes of conjunctiva induced by topical glaucoma medication 显示文摘 | Neneiu A Stefan C Ardelean C | 2004 | Oftamologia2004，48，1： | 1 |
| 13 | Structural and optical characterization of porous anodic aluminum oxide显示文摘 | AUREIAAN C GaLca STEFAN KOOIJ E HERBERT Wormeester | 2003 | J Appl Phys2003，94，7： | 1 |
| 14 | The role of intracellular oxidants in apoptosis 显示文摘 | Slater A F G Stefan C Nobel I | 1995 | Biochimica et Biophysica Acta (BBA) -Molecular Basis of Disease1995，1271，1： | 1 |
| 15 | Comparison of carotid stents: an in-vitro experiment focusing on stent design 显示文摘 | Stefan MH Philipp JS Nikolas C | 2009 | J Endovasc Ther2009，16，2： | 1 |
| 16 | Transverse mixing in wide and shallow river: Case study显示文摘 | DEMETRACOPOULOS A C STEFAN H G | 1983 | Journal of Environmental Engineering ASCE1983，109，3： | 1 |
| 17 | Comparison of carotidstents: an In-vitro Experiment focusing on stent design显示文摘 | Stefan MH Philipp JS Nikolas C | 2009 | J Endo-vasc Ther2009，16，2： | 1 |
| 18 | Transcutaneous vagus nerve stimulation (t-VNS) in pharmacoresistant epilepsies:a proof of concept trial显示文摘 | Stefan H Kreiselmeyer G Kerling F Kurzbuch K Rauch C Heers M | | 0，，： | 1 |
| 19 | CO Oxidation over Supported Gold Catalysts—“Inert” and “Active” Support Materials and Their Role for the Oxygen Supply during Reaction显示文摘 | Markus M Schubert Stefan Hackenberg Andre C van Veen Martin Muhler Vojtech Plzak R.Jürgen Behm | 2001 | Journal of Catalysis2001，，1： | 1 |
| 20 | Postoperative multichannel magnetoencephalography in patients with recurrent seizures after epilepsy surgery 显示文摘 | Kirchberger K Hummel C Stefan H | 1998 | Acta Neurol Scand1998，98，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员