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| 1 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 2 | Effects of retigabine on rhythmic synchronous activity of human neocortical slices显示文摘 | Straub H Kohling R Hohling J | 2001 | Epilepsy Res2001，44，23： | 1 |
| 3 | A potential vul- nerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity 显示文摘 | Straub R E MacLean C J O'Neill F A | 1995 | Nat Genet1995，11，3： | 1 |
| 4 | Discovery of the novel antithrombotic agent 5-ehloro-N- ( { ( 5 S ) -2 -oxo-3- -1,3-oxazolidin-5-yl } methyl ) thiophene-2- carboxamide( BAY 59-7939 ) : an oral, direct factor Xa inhibitor 显示文摘 | Roehrig S Straub A Pohlmann J | 2005 | J Med Chem2005，48，19： | 1 |
| 5 | Temperament and character in primary insomnia显示文摘 | de Saint Hilaire Z Straub J Pelissolo A | 2005 | Eur Psychiatry2005，20，： | 1 |
| 6 | Affective brain regions are activated during the processing of pain-related words in migraine patients显示文摘 | Eck J Richter M Straube T | 2011 | Pain2011，152，5： | 1 |
| 7 | Residual luminescence signals of recent river flood sediments: A comparison between quartz and feldspar of fine-and grain-sized sediments显示文摘 | FUCHS M STRAUB J ZOLLER L | 2005 | Ancient T12005，23，1： | 1 |
| 8 | Higher order aberration in normal,dilated,intraocular lens,and laser in situ keratomileusis cornea显示文摘 | Miller JM Anwaruddin R Straub J Schwiegerling J | 2002 | J Refract Surg2002，18，5： | 1 |
| 9 | Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes 显示文摘 | Straub RE MacLean C J Ma Y | 2002 | Mol Psychiatry2002，7，6： | 1 |
| 10 | Time-dependent depotentiation in the dentate gyrus of freely moving rats by repeated brief 7 Hz stimulation显示文摘 | STRAUBE T FREY J U | 2003 | Neuroscience Letters2003，339，1： | 1 |
| 11 | Concessions of infra- structure in Latin America: Government-led renegotiations 显示文摘 | Guasch J L Laffont J J Straub S | 2007 | Journal of Applied Econometrics2007，，： | 1 |
| 12 | Temperament and character in primary insomnia显示文摘 | Saint HZ Straub J Pelissolo A | 2005 | Eur Psychiatry2005，20，： | 1 |
| 13 | Renegotiating infrastructure concessions : an overview 显示文摘 | GUASCH J L STRAUB S | 2006 | Annals of Public and Cooperative Economics2006，，4： | 1 |
| 14 | Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- -1,3 -oxazolidin -5 -yl}methyl)thiophene-2-carboxamide (BAY 59-7939):an oral,direct factor Xa inhibitor显示文摘 | Roehrig S Straub A Pohlmann J | 2005 | J Med Chem2005，48，19： | 1 |
| 15 | Temperament and character in primary insomnia 显示文摘 | de Saint Hilaire Z Straub J Pelissolo A | 2005 | Eur Psychiatry2005，20，2： | 1 |
| 16 | Urinary cytology in era of fluorescence endoscopy: redefining the role of an established method with a new reference standard显示文摘 | TRITSCHLER S SOMMER M L STRAUB J | 2010 | Urolo- gy2010，76，3： | 1 |
| 17 | How psychological stress via hormones and nerve fibers may exacerbate rheumatoid arthritis显示文摘 | Rainer H Straub Firdaus and apoptosis Arthritis S Dhabhar Johannes W J Bijlsma | 2005 | Arthritis Rheum2005，52，1： | 1 |
| 18 | Critical Themes in Electronic Commerce Research: a Meta-analysis 显示文摘 | Wareham J Zheng JG Straub D | 2006 | Journal of Information Technology2006，20，1： | 1 |
| 19 | Diagnostic efficacy of surgeon - performed ultrasound - guided fine needle aspiration : A randomized controlled tril 显示文摘 | ROBITSCHEK J STRAUB M WIRTZ E | 2010 | Otolaryngol Hasd Neck Surg2010，142，3： | 1 |
| 20 | Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia显示文摘 | Callicott J H Straub R E Pezawas L | 2005 | Proc Natl Acad Sci USA2005，102，： | 1 |
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