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	题名	作者	年代	出处	被引量
1	Novel ATP8B1 mutation in an adult male with progressive familial intrahepatic cholestasis显示文摘Progressive familial intrahepatic cholestasis type 1 is a rare disease that is characterized by low serum γ-glutamyltransferase levels due to mutation inATP8B1.We present a 23-year-old male who experienced persistent marked pruritus for eighteen years and recurrent jaundice for thirteen years,in addition to cholestasis that eventually became fatal.Genetic sequencing studies of the entire coding(exon) sequences of ATP8B1 and ABCB11 uncovered a novel heterozygous missense 3035G>T mutation(S1012I) and a synonymous 696T>C mutation in ATP8B1.The patient's progression was associated with not only impaired familial intrahepatic cholestasis 1(FIC1) function but also impaired bile salt export pump expression due to the impaired FIC1 function.Our findings show that patients with intermittent cholestasis can develop progressive liver disease even after several decades and require regular follow up.	Bao-Cheng Deng Sa Lv Wei Cui Rui Zhao Xu LU Jian Wu Pei Liu	2012	World Journal of Gastroenterology2012，18，44：	2
2	Safety and drug utilization pro-file of varenicline as used in general practice in England: interimresults from a prescription-event monitoring study 显示文摘	Kasliwal R Wilton LV Shakir SA	2009	Drug Saf2009，32，6：	1
3	The safety profiles of orlistat and sibutramine: results of prescription-event monitoring studies in England显示文摘	Perrio MJ Wilton LV Shakir SA	2007	Obesity2007，15，11：	1
4	Evaluation of the safety of sildenafil for male erectile dysfunction:experience gained ingeneral practice use in England in 1999 显示文摘	Oshier A Wilton LV Shakir SA	2004	BJU Int2004，93，6：	1
5	Identification of novel molecular candidates for acute liver failure in plasma of BALB/c murine model显示文摘	SA LV WEI L WANG JH	2007	J Proteome Res2007，6，：	1
6	Evaluation of the safety of sildenafil for male erectile dysfunction: experience gained in general practice use in England in 1999显示文摘	Boshier A Wilton LV Shakir SA	2004	BJUlnt2004，93，6：	1
7	The safety of que- tiapine: results of a post-marketing surveillance study on 1 728 patients in England显示文摘	Twaites BR Wilton LV Shakir SA	2007	J Psychopharmacol2007，21，4：	1
8	The Pharmacovigilance of pantoprazole:the results of postmarketing surveillance on 11541 patients in England显示文摘	Wilton LV Key C Shakir SA	2003	Drug Saf2003，26，2：	1
9	Evaluation of the safety of sildenafil for male erectile dysfunction: experience gained in general practice use in England in 1999显示文摘	Boshier A Wilton LV Shakir SA	2004	BJUlnt2004，93，6：	1
10	Evaluation of the safety of sildenafil for male erectile dysfunction: experienee gained in general practice use in England in 1999显示文摘	Boshier A Wilton LV Shakir SA	2004	BJUlnt2004，93，6：	1
11	Balance and co- ordination training after sciatic nerve iniury显示文摘	Bonetti LV Korb A Da Silva SA	2011	Muscle Nerve2011，44，1：	1
12	Pediatric Clostridium difficile: a phantom menace or clinical reality? 显示文摘	McFarland LV Brandmarker SA Guandalini S	2000	J Pediatr Gastroenterol Nutr2000，31，3：	1
13	Cardiovascular events in users of sildenafil: results from first phase of prescription event monitoring in England 显示文摘	Shakir SA Wilton LV Boshier A	2001	BMJ2001，322，7287：	1
14	Safety profile of refecoxib as used in general practice in England: results of a prescription-event monitoring study显示文摘	Layton D Riley J Wilton LV Shakir SA	2003	Br J Clin Pharmacol2003，55，23：	1
15	Use and risk management of carvedilol for the treatment of heart failure in the community in England: results from a modified prescription-event monitoring study显示文摘	AURICH-BARRERA B WILTON LV SHAKIR SA	2009	Drug Saf2009，32，1：	1
16	The pharmacovigilance of pantoprazole: the results of postmarketing surveillance on 11541 patients in England 显示文摘	Wilton LV Key C Shakir SA	2003	Drug Safety2003，26，2：	1
17	Sudden unexplained death in epilepsy autopsied patients显示文摘	Antonluk SA Oliva LV Bruck I	2001	Arq Neunrpsiquiatr2001，59，：	1
18	Grape seed extract inhibits VEGF expression via reducing HIF - 1alpha protein expression显示文摘	LV JM ZHANG KQ CHEN SA	2009	Carcinogenesis2009，304，：	1
19	All-codon scanning identifies p53 Cancer rescue mutations显示文摘	Baronio R Danziger SA Hall LV		0，，20：	1
20	Phase I clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumors 显示文摘	Beerepoot LV Radema SA Witteveen EO	2006	J Clin 0ncol2006，24，10：	1

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