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| 1 | Irinotecan therapy and molecular targets in colorectal cancer: A systemic review显示文摘Irinotecan is the second line chemotherapy for advanced stage colorectal cancer (CRC) after failure of first line chemotherapy with oxaliplatin and 5-fluorouracil. The aim of this review is to analyse the data on irinotecan as second line chemotherapy for advanced CRC and the potential roles of the molecular markers, p53 and vascular endothelial growth factor (VEGF) in the management of advanced CRC. Thus, the English literature from 1980 to 2008 concerning irinotecan, p53, VEGF and CRC was reviewed. On review, Phase and clinical trials showed thatirinotecan improves pain-free survival, quality of life, 1-year survival, progression-free survival and overall survival in advanced CRC. p53 and VEGF were expressed in CRC and had a predictive power of aggressive clinical behaviour in CRC. Irinotecan sensitizes p53 wild type, mutant and null cells to Fasmediated cell apoptosis in CRC cells. Wild type p53 cells were more sensitive to irinotecan than mutated p53. Irinotecan has an anti-VEGF effect inhibiting endothelial cell proliferation, increasing apoptosis and reducing microvascular density which is onlylimited by irinotecan toxicity levels. To conclude, irinotecan improves the patient's quality of life and the survival rates of patients with advanced CRC. p53 and VEGF status of the patients' tumour is likely to affect the responsiveness of CRC to irinotecan. It is recommended that studies of the expression of these molecular markers in relation to chemoresponsiveness ofirinotecan should be carried out for better management of patients with advanced CRC. | Jessica Weekes Alfred King-Yin Lam Sabe Sebesan Yik-Hong Ho | 2009 | World Journal of Gastroenterology2009，15，29： | 9 |
| 2 | Flow cytometric analysis of estrogen receptor expression in isolated nuclei and cell from mammary cancer tissues显示文摘 | Sabe I Andritsch I Magoud A | 1999 | Cytometry1999，36，： | 1 |
| 3 | The Role Of Inertial Sensi- tivity In Motor Planning 显示文摘 | P N Sabes M I Jordan D M Wolpert | 2005 | Journal Of Neuroscience2005，，18： | 1 |
| 4 | Does alternative food al- ways enhance biological control? The effect of pollen on the interaction between western flower thrips and its predators 显示文摘 | van Rijn P C J Sabelis M W | 1993 | IOBC/WPRS Bulletin1993，16，8： | 1 |
| 5 | Effect of ice compression on pain after mandibular third molar surgery: a single-blind, randomized controlled trial显示文摘 | T. Forouzanfar A. Sabelis S. Ausems J.A. Baart I. van der Waal | 2008 | International Journal of Oral & Maxillofacial Surgery2008，，9： | 1 |
| 6 | A Rendering Algorithm for Visualization 3D Scalar Fields显示文摘 | Sabe P | 1988 | Computer Graphics1988，22，4： | 1 |
| 7 | Odour-mediated sexual attraction in nabids (Heteroptera:Nabidae)显示文摘 | Rolh S Janssen A Sabelis M W | 2008 | European Journal of Entomology2008，105，1： | 1 |
| 8 | Plant strategies of manipulating predatorprey interactions through allelochemicals :Prospects for applaction in pest control 显示文摘 | DICKE M SABELIS M W TAKABAYASHI J | 1990 | Journal of chemical ecology1990，，： | 1 |
| 9 | Enhanced lysis activity of cytokine induced killer cells against multiple myeloma cells after co-culture with idiotype-pulsed dendritic cells 显示文摘 | Angena M Sabing R Marie L T | 2001 | Haematologica2001，86，10： | 1 |
| 10 | Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins显示文摘 | Mazaki Y Hashimoto S Sabe H | 1997 | J Biol Chem1997，272，11： | 1 |
| 11 | Regional volumetric coronary blood flow measurement by digital angiography:In vivo validation显示文摘 | Sabee M Yifang Z Ghassan SK | 2004 | Acad Radiol2004，11，3： | 1 |
| 12 | An overview of common procedures for the man- agement of tinnitus patients显示文摘 | Sweetow RW Sabes JH | 2010 | The Heating Journal2010，63，11： | 1 |
| 13 | Mathematical models of predator/prey/plant interactions in a patch environment显示文摘 | O. Diekmann J. A. Metz M. W. Sabelis | 1988 | Experimental and Applied Acarology1988，，3： | 1 |
| 14 | ArfGAP family proteins in cell adhesion, migration and tumor invasion 显示文摘 | Sabe H Onodera Y Mazaki Y | 2006 | CUIT Opin Cell Biol2006，18，5： | 1 |
| 15 | Toxicity of methyl ketones from tomato trichomes to Tetranychus urticae Koch显示文摘 | Chatzivasileiadis E A Sabelis M W | 1997 | Experimental & Applied Acarology1997，21，： | 1 |
| 16 | Differential timing of spider mite-induced direct and indirect defenses in tomato plants显示文摘 | KANT M R AMENT K SABELIS M W | 2004 | Plant Physiol2004，135，1： | 1 |
| 17 | A rendering algorithm for visualization 3D scalar fields显示文摘 | Sabe P | 1988 | Computer Graohics1988，22，4： | 1 |
| 18 | Mucoepidermoid carcinoma of minorsalivary glands: report of 17 cases with follow-up 显示文摘 | Eversole LR Rovin S Sabes WR | 1972 | J Oral Surg1972，30，： | 1 |
| 19 | New approaches to the extraction of arsenic species from soils显示文摘 | RUIZ C M J SABE R LOPEZ S J F | 2005 | Microchimica Acta2005，151，： | 1 |
| 20 | Molecular pharmacology of vitamin E: Strctural aspects of antioxidant activity 显示文摘 | Van Acker SABE Koymans LMH Bast A | 1993 | Free Radical Biologw & Medicine1993，15，： | 1 |
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