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| 1 | Fibroadhesive scarring of grafted collagen scaffolds interferes with implant–host neural tissue integration and bridging in experimental spinal cord injury显示文摘Severe traumatic spinal cord injury(SCI)results in a devastating and permanent loss of function,and is currently an incurable condition.It is generally accepted that future intervention strategies will require combinational approaches,including bioengineered scaffolds,to support axon growth across tissue scarring and cystic cavitation.Previously,we demonstrated that implantation of a microporous type-I collagen scaffold into an experimental model of SCI was capable of supporting functional recovery in the absence of extensive implant–host neural tissue integration.Here,we demonstrate the reactive host cellular responses that may be detrimental to neural tissue integration after implantation of collagen scaffolds into unilateral resection injuries of the adult rat spinal cord.Immunohistochemistry demonstrated scattered fibroblast-like cell infiltration throughout the scaffolds as well as the presence of variable layers of densely packed cells,the fine processes of which extended along the graft–host interface.Few reactive astroglial or regenerating axonal profiles could be seen traversing this layer.Such encapsulation-type behaviour around bioengineered scaffolds impedes the integration of host neural tissues and reduces the intended bridging role of the implant.Characterization of the cellular and molecular mechanisms underpinning this behaviour will be pivotal in the future design of collagen-based bridging scaffolds intended for regenerative medicine. | Haktan Altinova Sebastian Hammes Moniek Palm Jose Gerardo-Nava Pascal Achenbach Ronald Deumens Emmanuel Hermans Tobias Fuhrmann Arne Boecker Sabien Geraldine Antonia van Neerven Ahmet Bozkurt Joachim Weis Gary Anthony Brook | 2019 | Regenerative Biomaterials2019，6，2： | 4 |
| 2 | Speciation of Zn, Cu, and Pb in the soil depending on soil texture and fertilizationwith sewage sludge compost 显示文摘 | Brazauskiene D Paulauskas V Sabiene N | 2008 | Journal of Soils and Sediments2008，8，3： | 1 |
| 3 | Has International Trade Affected Workers' Bargaining Power?显示文摘 | Ellen Brock Sabien Dobbelaere | 2006 | Review of World Economics2006，，2： | 1 |
| 4 | Estimation of Price-cost Margins and Union Bargaining Power for Belgian Manufacturing显示文摘 | Sabien Dobbelaere | 2004 | In- ternational Journal of Industrial Organization2004，，10： | 1 |
| 5 | Speciation of Zn,Cu,and Pb in the soil depending on soil texture and fertilization with sewage sludge compost显示文摘 | Brazauskiene D M Paulauskas V Sabiene N | 2008 | Journal of soils and sediments2008，8，3： | 1 |
| 6 | Determination of heavy metal mobile forms by different extraction methods 显示文摘 | SABIENE N BRAZAUSKIENE D M RIMMER D | 2004 | Ekologija2004，1，： | 1 |
| 7 | Mechanical work in running显示文摘 | Caragna G A Sabiene F P Margavia R | 1987 | Appl physiology1987，19，： | 1 |
| 8 | Speciation of Zn, Cu, and Pb in the soil depending on soil texture and fertilization with sewage sludge compost显示文摘 | Dalia-Marija Brazauskiene Valdas Paulauskas Nomeda Sabiene | 2008 | Journal of Soils and Sediments2008，，3： | 1 |
| 9 | Ownership, firm size and rent sharing in Bulgaria显示文摘 | Sabien Dobbelaere | 2003 | Labour Economics2003，，2： | 1 |
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