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| 1 | Clinical role of non-invasive assessment of portal hypertension显示文摘Measurement of portal pressure is pivotal in the evaluation of patients with liver cirrhosis. The measurement of the hepatic venous pressure gradient represents the reference method by which portal pressure is estimated. However, it is an invasive procedure that requires significant hospital resources, including experienced staff, and is associated with considerable cost. Non-invasive methods that can be reliably used to estimate the presence and the degree of portal hypertension are urgently needed in clinical practice. Biochemical and morphological parameters have been proposed for this purpose, but have shown disappointing results overall. Splanchnic Doppler ultrasonography and the analysis of microbubble contrast agent kinetics with contrast-enhanced ultrasonography have shown better accuracy for the evaluation of patients with portal hypertension. A key advancement in the non-invasive evaluation of portal hypertension has been the introduction in clinical practice of methods able to measure stiffness in the liver, as well as stiffness/congestion in the spleen. According to the data published to date, it appears to be possible to rule out clinically significant portal hypertension in patients with cirrhosis(i.e., hepatic venous pressure gradient ≥ 10 mm Hg) with a level of clinically-acceptable accuracy by combining measurements of liver stiffness and spleen stiffness along with Doppler ultrasound evaluation. It is probable that the combination of these methods may also allow for the identification of patients with the most serious degree of portal hypertension, and ongoing research is helping to ensure progress in this field. | Massimo Bolognesi Marco Di Pascoli David Sacerdoti | 2017 | World Journal of Gastroenterology2017，23，1： | 12 |
| 2 | Covert hepatic encephalopathy: Agreement and predictive validity of different indices显示文摘AIM:To investigate the agreement and prognosticvalue of different measures of covert hepatic encephalopathy(CHE).METHODS:One-hundred-and-thirty-two cirrhotic outpatients underwent electroencephalography(EEG),paper-and-pencil psychometry(PHES)and critical flicker frequency,scored on the original/modified(CFFo/CFFm)thresholds.Eighty-four patients underwent Dopplerultrasound to diagnose/exclude portal-systemic shunt.Seventy-nine were followed-up for 11±7 mo in relation to the occurrence of hepatic encephalopathy(HE)-related hospitalisations.RESULTS:On the day of study,36%had gradeⅠHE,42%abnormal EEG,33%abnormal PHES and 31/21%abnormal CFFo/CFFm.Significant associations were observed between combinations of test abnormalities;however,agreement was poor(Cohen’sκ<0.4).The prevalence of EEG,PHES and CFFo/CFFm abnormalities was significantly higher in patients with gradeⅠovert HE.The prevalence of EEG and CFFm abnormalities was higher in patients with shunt.The prevalence of EEG abnormalities was significantly higher in patients with a history of HE.During follow-up,10 patients died,10were transplanted and 29 had HE-related hospitalisations.GradeⅠHE(P=0.004),abnormal EEG(P=0.008)and abnormal PHES(P=0.04)at baseline all predicted the subsequent occurrence of HE;CFF did not.CONCLUSION:CHE diagnosis probably requires a combination of clinical,neurophysiological and neuropsychological indices. | Sara Montagnese Esmeralda Balistreri Sami Schiff Michele De Rui Paolo Angeli Giacomo Zanus Umberto Cillo Giancarlo Bombonato Massimo Bolognesi David Sacerdoti Angelo Gatta Carlo Merkel Piero Amodio | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 3 | Natural heme oxygenase-1 inducers in hepatobiliary function显示文摘Many physiological effects of natural antioxidants,their extracts or their major active components,have been reported in recent decades.Most of these compounds are characterized by a phenolic structure,similar to that of α-tocopherol,and present antioxidant proper-ties that have been demonstrated both in vitro and in vivo.Polyphenols may increase the capacity of en-dogenous antioxidant defences and modulate the cellu-lar redox state.Changes in the cellular redox state may have wide-ranging consequences for cellular growth and differentiation.The majority of in vitro and in vivo studies conducted so far have attributed the protective effect of bioactive polyphenols to their chemical reac-tivity toward free radicals and their capacity to prevent the oxidation of important intracellular components.However,in recent years a possible novel aspect in the mode of action of these compounds has been sug-gested; that is,the ultimate stimulation of the heme oxygenase-1 (HO-1) pathway is likely to account for the established and powerful antioxidant/anti-inflam-matory properties of these polyphenols.The products of the HO-catalyzed reaction,particularly carbon mon-oxide (CO) and biliverdin/bilirubin have been shown to exert protective effects in several organs against oxidative and other noxious stimuli.In this context,it is interesting to note that induction of HO-1 expression by means of natural compounds contributes to protec-tion against liver damage in various experimental mod-els.The focus of this review is on the significance of targeted induction of HO-1 as a potential therapeutic strategy to protect the liver against various stressors in several pathological conditions. | Giovanni Li Volti David Sacerdoti Claudia Di Giacomo Maria Luisa Barcellona Antonio Scacco Paolo Murabito Antonio Biondi Francesco Basile Diego Gazzolo Raul Abella Alessandro Frigiola Fabio Galvano | 2008 | World Journal of Gastroenterology2008，14，40： | 2 |
| 4 | Dentoskeletal features associated with uni- lateral or bilateral palatal displacement of maxillary canines 显示文摘 | Sacerdoti R Baccetti T | 2004 | Angle Orthodontist2004，74，6： | 1 |
| 5 | The hemody- namic response to medical treatment of portal hyertension as a predic- tor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis显示文摘 | MERKEL C BOLOGNESI M SACERDOTI D | 2000 | Hepatology2000，32，： | 1 |
| 6 | Splenic Doppler impedance indices:influence of different portal hemodynamic conditions显示文摘 | Bolognesi Sacerdoti D Merkelc | 1996 | Hepatology1996，23，5： | 1 |
| 7 | Hepatic arterial resistance in cirrhosis with and without portal vein thrombosis: relationships with portal hemodynamics显示文摘 | Merkel C | 1995 | Gastroenterology1995，108，： | 1 |
| 8 | Carbon monoxide signaling in promoting angiogenesis in human mierovessel endothelial cells 显示文摘 | Volti GL Sacerdoti D Sangras B | 2005 | Antioxid Redox Signal2005，7，6： | 1 |
| 9 | Arterioportal fistulas in patients with liver cirrhosis:usefulness of color Doppler US for screening显示文摘 | Bolognesi M Sacerdoti D Bombonato G | 2000 | Radiology2000，216，3： | 1 |
| 10 | Role of spleen enlargement in cirrhosis with portal hypertension显示文摘 | Bolognesi M Merkel C Sacerdoti D | 2002 | Dig Liver Dis2002，34，2： | 1 |
| 11 | Heine oxygenase - 1 trnsduction in endothelial cells causes downregulatinn of monocyte chemoattractant protein - 1 and of genes involved in inflammation and growth显示文摘 | Sacerdoti D Colombrita C Ghattas MH | 2005 | Cell Mol Biol2005，51，2： | 1 |
| 12 | Hepatic arterial resistance in cirrhosis with and without portal vein thrombosis: relationships with portal hemodynamics 显示文摘 | Sacerdoti D Merkel C Bolognesi M | 1995 | Gastroenterology1995，108，： | 1 |
| 13 | Role of spleen enlargement in cirrhosis with portal hypertension 显示文摘 | BOLOGNESI M MERKEL C SACERDOTI D | 2002 | Dig Liver Dis2002，34，2： | 1 |
| 14 | Carbon monoxide signaling in promoting angiogenesis in human mierovessel endothelial cells显示文摘 | Volti GL Sacerdoti D Sangras B | 2005 | Antioxid Redox Signal2005，7，6： | 1 |
| 15 | Role of spleen enlargement in cirrhosis with portal hypertension 显示文摘 | BOLOGNESI M MERKEL C SACERDOTI D | 2002 | Dig Liver Dis2002，34，1： | 1 |
| 16 | The role carbon monoxide and heme oxygenase in the alteration of mesenteric and porto- hepatic circulation of cirrhotic rats 显示文摘 | Adebayo O Jiang S | 1999 | Hepatology1999，30，： | 1 |
| 17 | Arterioportal fistulas in patients with liver cirrhosis: usefulness of color Doppler US for screening显示文摘 | Bolognesi M Sacerdoti D Bombonato C | 2000 | Radiology2000，216，3： | 1 |
| 18 | Relationship between portal blood flow measured by image--directed Doppler ultrasonography and hepatic blood flow measured by Indocyanine green constant infusion in patients with cirrhosisl显示文摘 | Bolognesi M Sacerdoti D Merkel C | 1995 | JUC1995，23，： | 1 |
| 19 | Carbon monoxide-mediated activation of large-conductance calcium-activated potassium channels contributes to mesenteric vasodilatation in cirrhotic rats显示文摘 | BOLOGNESI M SACERDOTI D PIVA A | 2007 | Pharmacol Exp Ther2007，321，1： | 1 |
| 20 | The rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid(EET) is mediated by activating heme oxygenase(HO)显示文摘 | Sacerdoti D Bolognesi M Di Pascoli M | 2006 | Am J Physiol Heart Circ Physiol2006，291，： | 1 |
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