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| 1 | Splanchnic vasodilation and hyperdynamic circulatory syndrome in cirrhosis显示文摘Portal hypertension is a clinical syndrome which leads to several clinical complications,such as the formation and rupture of esophageal and/or gastric varices,ascites,hepatic encephalopathy and hepato-renal syndrome.In cirrhosis,the primary cause of the increase in portal pressure is the enhanced resistance to portal outflow.However,also an increase in splanchnic blood flow worsens and maintains portal hypertension.The vasodilatation of arterial splanchnic vessels and the opening of collateral circulation are the determinants of the increased splanchnic blood flow.Several vasoactive systems/substances,such as nitric oxide,cyclooxygenase-derivatives,carbon monoxide and endogenous cannabinoids are activated in portal hypertension and are responsible for the marked splanchnic vasodilatation.Moreover,an impaired reactivity to vasoconstrictor systems,such as the sympathetic nervous system,vasopressin,angiotensinⅡand endothelin-1,plays a role in this process.The opening of collateral circulation occurs through the reperfusion and dilatation of preexisting vessels,but also through the generation of new vessels.Splanchnic vasodilatation leads to the onset of the hyperdynamic circulatory syndrome,a syndrome which occurs in pa-tients with portal hypertension and is characterized by increased cardiac output and heart rate,and decreased systemic vascular resistance with low arterial blood pressure.Understanding the pathophysiology of splanchnic vasodilatation and hyperdynamic circulatory syndrome is mandatory for the prevention and treatment of portal hypertension and its severe complications. | Massimo Bolognesi Marco Di Pascoli Alberto Verardo Angelo Gatta | 2014 | World Journal of Gastroenterology2014，20，10： | 21 |
| 2 | Covert hepatic encephalopathy: Agreement and predictive validity of different indices显示文摘AIM:To investigate the agreement and prognosticvalue of different measures of covert hepatic encephalopathy(CHE).METHODS:One-hundred-and-thirty-two cirrhotic outpatients underwent electroencephalography(EEG),paper-and-pencil psychometry(PHES)and critical flicker frequency,scored on the original/modified(CFFo/CFFm)thresholds.Eighty-four patients underwent Dopplerultrasound to diagnose/exclude portal-systemic shunt.Seventy-nine were followed-up for 11±7 mo in relation to the occurrence of hepatic encephalopathy(HE)-related hospitalisations.RESULTS:On the day of study,36%had gradeⅠHE,42%abnormal EEG,33%abnormal PHES and 31/21%abnormal CFFo/CFFm.Significant associations were observed between combinations of test abnormalities;however,agreement was poor(Cohen’sκ<0.4).The prevalence of EEG,PHES and CFFo/CFFm abnormalities was significantly higher in patients with gradeⅠovert HE.The prevalence of EEG and CFFm abnormalities was higher in patients with shunt.The prevalence of EEG abnormalities was significantly higher in patients with a history of HE.During follow-up,10 patients died,10were transplanted and 29 had HE-related hospitalisations.GradeⅠHE(P=0.004),abnormal EEG(P=0.008)and abnormal PHES(P=0.04)at baseline all predicted the subsequent occurrence of HE;CFF did not.CONCLUSION:CHE diagnosis probably requires a combination of clinical,neurophysiological and neuropsychological indices. | Sara Montagnese Esmeralda Balistreri Sami Schiff Michele De Rui Paolo Angeli Giacomo Zanus Umberto Cillo Giancarlo Bombonato Massimo Bolognesi David Sacerdoti Angelo Gatta Carlo Merkel Piero Amodio | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 3 | Culture-Based Selection Therapy for Patients Who Did Not Respond to Previous Treatment for Helicobacter pylori Infection显示文摘 | Giulia Fiorini Nimish Vakil Angelo Zullo Ilaria M. Saracino Valentina Castelli Chiara Ricci Cristina Zaccaro Luigi Gatta Dino Vaira | 2012 | Clinical Gastroenterology and Hepatology2012，，： | 3 |
| 4 | Natural history of cirrhotic patients with small esophageal varices: a prospective study显示文摘 | Marco Zoli Carlo Merkel Donatella Magalotti Cristina Gueli Michele Grimaldi Angelo Gatta Mauro Bernardi | 2000 | The American Journal of Gastroenterology2000，，2： | 1 |
| 5 | Hemodynamic changes of systemic, hepatic, and splenic circulation following triglycyl-lysin-vasopressin administration in alcoholic cirrhosis显示文摘 | Dr. Carlo Merkel MD Angelo Gatta MD Massimo Bolognesi MD Gianfranco Finucci MD Giorgio Battaglia MD Paolo Angeli MD Renzo Zuin MD | 1988 | Digestive Diseases and Sciences1988，，9： | 1 |
| 6 | Detection of minimal hepatic encephalopathy: Normalization and optimization of the Psychometric Hepatic Encephalopathy Score. A neuropsychological and quantified EEG study显示文摘 | Piero Amodio Francesca Campagna Stefania Olianas Pamela Iannizzi Daniela Mapelli Marco Penzo Paolo Angeli Angelo Gatta | 2008 | Journal of Hepatology2008，，3： | 1 |
| 7 | Sleep‐wake abnormalities in patients with cirrhosis显示文摘 | Sara Montagnese Cristiano De Pittà Michele De Rui Michela Corrias Matteo Turco Carlo Merkel Piero Amodio Rodolfo Costa Debra J. Skene Angelo Gatta | 2014 | Hepatology2014，，2： | 1 |
| 8 | Prognostic value of galactose elimination capacity, aminopyrine breath test, and ICG clearance in patients with cirrhosis显示文摘 | Dr. Carlo Merkel MD Angelo Gatta MD Marco Zoli MD Massimo Bolognesi MD Paolo Angeli MD Tiziana Iervese MD Giulio Marchesini MD Arturo Ruol MD | 1991 | Digestive Diseases and Sciences1991，，9： | 1 |
| 9 | Detection of minimal hepatic encephalopathy: Normalization and optimization of the Psychometric Hepatic Encephalopathy Score. A neuropsychological and quantified EEG study显示文摘 | Piero Amodio Francesca Campagna Stefania Olianas Pamela Iannizzi Daniela Mapelli Marco Penzo Paolo Angeli Angelo Gatta | 2008 | Journal of Hepatology2008，，3： | 1 |
| 10 | Central Nervous System Alterations in Liver Cirrhosis: The Role of Portal-Systemic Shunt and Portal Hypoperfusion显示文摘 | Franco Del Piccolo David Sacerdoti Piero Amodio Giancarlo Bombonato Massimo Bolognesi Daniela Mapelli Angelo Gatta | 2003 | Metabolic Brain Disease2003，，1： | 1 |
| 11 | Natural history of cirrhotic patients with small esophageal varices: a prospective study显示文摘 | Marco Zoli Carlo Merkel Donatella Magalotti Cristina Gueli Michele Grimaldi Angelo Gatta Mauro Bernardi | 2000 | The American Journal of Gastroenterology2000，，2： | 1 |
| 12 | Evaluation of the Acute Kidney Injury Network criteria in hospitalized patients with cirrhosis and ascites显示文摘 | Salvatore Piano Silvia Rosi Giulio Maresio Silvano Fasolato Marta Cavallin Antonietta Romano Filippo Morando Elisabetta Gola Anna Chiara Frigo Angelo Gatta Paolo Angeli | 2013 | Journal of Hepatology2013，，： | 1 |
| 13 | Positive cardiac inotropic effect of albumin infusion in rodents with cirrhosis and ascites: molecular mechanisms显示文摘 | Alessia Bortoluzzi Giulio Ceolotto Elisabetta Gola Antonietta Sticca Sergio Bova Filippo Morando Salvatore Piano Silvano Fasolato Silvia Rosi Angelo Gatta Paolo Angeli | 2013 | Hepatology2013，，1： | 1 |
| 14 | Vasoactive factors and hemodynamic mechanisms in the pathophysiology of portal hypertension in cirrhosis显示文摘 | Angelo Gatta Massimo Bolognesi Carlo Merkel | 2007 | Molecular Aspects of Medicine2007，，1： | 1 |
| 15 | Detection of minimal hepatic encephalopathy: Normalization and optimization of the Psychometric Hepatic Encephalopathy Score. A neuropsychological and quantified EEG study显示文摘 | Piero Amodio Francesca Campagna Stefania Olianas Pamela Iannizzi Daniela Mapelli Marco Penzo Paolo Angeli Angelo Gatta | 2008 | Journal of Hepatology2008，，3： | 1 |
| 16 | Top-down and bottom-up processes in the extrastriate cortex of cirrhotic patients: An ERP study显示文摘 | Sami Schiff Daniela Mapelli Antonino Vallesi Raffaele Orsato Angelo Gatta Carlo Umiltà Piero Amodio | 2006 | Clinical Neurophysiology2006，，8： | 1 |
| 17 | Natural history of cirrhotic patients with small esophageal varices: a prospective study显示文摘 | Marco Zoli Carlo Merkel Donatella Magalotti Cristina Gueli Michele Grimaldi Angelo Gatta Mauro Bernardi | 2000 | The American Journal of Gastroenterology2000，，2： | 1 |
| 18 | Prognostic value of galactose elimination capacity, aminopyrine breath test, and ICG clearance in patients with cirrhosis显示文摘 | Dr. Carlo Merkel MD Angelo Gatta MD Marco Zoli MD Massimo Bolognesi MD Paolo Angeli MD Tiziana Iervese MD Giulio Marchesini MD Arturo Ruol MD | 1991 | Digestive Diseases and Sciences1991，，9： | 1 |
| 19 | Spontaneous bacterial peritonitis due to carbapenemase-producing Klebsiella pneumoniae: the last therapeutic challenge显示文摘 | Salvatore Piano Antonietta Romano Silvia Rosi Angelo Gatta Paolo Angeli | 2012 | European Journal of Gastroenterology & Hepatology2012，，10： | 1 |
| 20 | Vasoactive factors and hemodynamic mechanisms in the pathophysiology of portal hypertension in cirrhosis显示文摘 | Angelo Gatta Massimo Bolognesi Carlo Merkel | 2007 | Molecular Aspects of Medicine2007，，1： | 1 |
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