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| 1 | 糖尿病视网膜病变患者高密度脂蛋白-3和总抗氧化能力以及NO_x水平分析(英文)显示文摘目的:比较糖尿病视网膜病变组与对照组数据,以研究高密度脂蛋白-3(HDL_3)、NO_x和总抗氧化状态之间的关系。方法:前瞻性病例对照研究。106例受试者分为3组,84例2型糖尿病有或无视网膜病变患者,对照组为22例正常人。患者均行血清高密度脂蛋白-3的浓度检测和血清NO_x水平测定。用铁还原法(FRAP)测量血浆总抗氧化能力。结果:糖尿病患者(DM)空腹血糖、糖化血红蛋白、甘油三酯显著高于对照组。正常人中HDL_3水平为14.4(12.0)mg/dL,糖尿病视网膜病变患者为18.1(12.6)mg/dL,糖尿病无视网膜病变患者为14.0(12.5)mg/dL,组间差异无统计学意义(P=0.262)。糖尿病患者FRAP水平低于对照组(P=0.003),但糖尿病视网膜病变组与非糖尿病视网膜病变组之间其差异无统计学意义。结论:研究发现:2型糖尿病视网膜病变患者、糖尿病无视网膜病变患者以及对照组间HDL和HDL_3水平无明显不同。HDL_3可能无法预测糖尿病视网膜病变患者的患病风险。糖尿病患者中血清NO_x水平较高,FRAP水平较低。 | Ustundag Yasemin Akdogan Müberra Demirci Hakan Günay Leyla Huysal Kagan Cevik Sadik Gorkem Barazi Ayse | 2017 | 国际眼科杂志2017，17，12： | 3 |
| 2 | Protective effect of L-camitine on renal ischaemia - reperfusion injury in the rat 显示文摘 | Sadik G Ozlen TB Gurbuz P | 2005 | Cell Biochem Funct2005，23，3： | 1 |
| 3 | Outcome of surgery for lung cancer in young and elderly patients显示文摘 | SERKAN Y SONER G SADIK Y | 2005 | Surg Today2005，35，10： | 1 |
| 4 | Role of sulfurous mineral water and sodium hydrosulfide as potent inhibitors of fibrosis in the heart of diabetic rats 显示文摘 | E1-Seweidy M M Sadik N A Shaker O G | 2011 | Arch Biochem Biophys2011，506，1： | 1 |
| 5 | Role of sulfurous mineral water and sodium hydrosulfide as potent in- hibitors of fibrosis in the heart of diabetic rats显示文摘 | EL-SEWEIDY M M SADIK N A SHAKER O G | 2011 | Arch Biochem Biophys2011，506，1： | 1 |
| 6 | Complete Model Develop- ment for an Optical Current Transformer显示文摘 | KUCUKSARI Sadik Karady George G | 2012 | IEEE Transactions on Power Delivery2012，27，4： | 1 |
| 7 | Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein, implications for the mechanism of tau aggregation显示文摘 | SADIK G TANAKA T KATO K | 2009 | J Neu- rochem2009，108，1： | 1 |
| 8 | Transforming growth factor beta1 and monocyte chemoattractant protein-1 as prognostic markers of diabetic nephropathy显示文摘 | Shaker O G Sadik N A | 2013 | Hum Exp Toxicol2013，32，10： | 1 |
| 9 | Antimicrobial and cytotoxic constituents of Loranthus globosus 显示文摘 | Sadik G Islam R Rahman M M | 2003 | Fitoterapia2003，74，3： | 1 |
| 10 | Periprostatic nerve blockage reduces postoperative analgesic consumption and pain scores of patients undergoing transurethral prostate resection 显示文摘 | Sadik G Kerem I | 2007 | Urologia Int2007，79，： | 1 |
| 11 | Pressure assisted chelating extraction as a teaching tool in instrumental analysis显示文摘 | Sadik O A Wanekaya A K Yevgeny G | | Journal of Chemical Education0，81，8： | 1 |
| 12 | The analgesic efficacy of preoperative versus postoperative lomoxicam in varicocele repair显示文摘 | Kerem I Sadik G Cagla OA | | 0，，08： | 1 |
| 13 | Pressure-assisted chelating extraction as a teaching tool in instrumental analysis显示文摘 | Sadik O A Wanekaya A K Yevgeny G | | Journal of Chemical Education0，81，8： | 1 |
| 14 | Comparison of two different treatment regimens’ efficacy in neovascular age-related macular degeneration in Turkish population—based on real life data-Bosphorus RWE Study Group显示文摘AIM: To compare two different anti-vascular endothelial growth factor(anti-VEGF) treatment regimens'-a priori pro re nata(PRN) and PRN regimen following^(th)e loading phaseanatomical and functional results in neovascular agerelated macular degeneration(n AMD) patients. METHODS: Totally 544 n AMD patients followed and treated with aflibercept(n=135) and ranibizumab(n=409)at 9 different centers between 2013 and 2015 were enrolled into^(th)is retrospective multicenter study. Patients with initial best corrected visual acuity(BCVA) interval of 1.3-0.3(log MAR) and a minimum follow-up of 12 mo were included. Patients under two different regimens-a priori pro re nata(1+PRN) or 3 consecutive intravitreal injections followed by a PRN regimen(3+PRN)-were compared in BCVA at 3^(th), 6^(th) and 12^(th) months, and in central macular^(th)ickness(CMT) at 6^(th) and 12^(th) months. The total study group, intravitreal ranibizumab(IVR) and intravitreal aflibercept(IVA) groups were evaluated separately. RESULTS: The mean CMT decreased in^(th)e 1+PRN(n=101) regimen from 407 to 358 and 340 μm and in^(th)e 3+PRN(n=443) group from 398 to 318 and finally to 310 μm at months 6 and 12, respectively. Anatomically,^(th)e CMT reduction at 6^(th) month(48.5 vs 76.4;P<0.05) was statistically significant in favor of 3+PRN group. BCVA changed in 1+PRN group from 0.77 to 0.78, 0.75 and 0.75;in 3+PRN group from 0.81 to 0.69, 0.72, and 0.76 at months 3, 6, and 12, respectively. Visual gain was statistically better in 3+PRN group at 3^(th) month(-0.01 vs 0.12;P<0.001). In IVR group, CMT reduction was in greater in 3+PRN at 6^(th)(44 vs 72) and 12^(th) month(61 vs 84), but statistically insignificant. The 3+PRN group revealed statistically better visual results at 3^(th) month(-0.02 vs 0.11, P<0.05). In IVA group, although statistically insignificant, CMT reduction(61 vs 89, 6^(th) month;85 vs 97, 12^(th) month) and visual gain(0.02 vs 0.16;0.02 vs 0.14;0.05 vs 0.11) was found in favor of 3+PRN group at all visits.CONCLUSION: The loading dose of anti-VEGF treatments in n AMD leads to significantly better anatomical and functional results, regardless of the agent, specially in early follow-up interval. | Burak Erden Selim Bolükbasi Abdullah Ozkaya Levent Karabas Cengiz Alagoz Zeynep Alkin Ozgür Artunay Sadik Etka Bayramoglu Gokhan Demir Mehmet Demir Ali Demircan Gürkan Erdogan Mehmet Erdogan Erdem Eris Havva Kaldirim Ismail Umut Onur Ozen Ayranci Osmanbasoglu Sezin Ozdogan Erkul Mine Oztürk Irfan Perente Kübra Sarici Nihat Sayin Dilek Yasa Ihsan Yilmaz Zeynep Yilmazabdurrahmanoglu 无 | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 1 |
| 15 | Transforming growth factor beta 1 and monocyte chemoattractant protein-1 as prognostic markers of diabetic nephropathy显示文摘 | Shaker O G Sadik N A | 2013 | Hum Exp Toxicol2013，32，10： | 1 |
| 16 | Antibacterial and cytotoxic compounds from the bark of Cananga odorata 显示文摘 | Rahman M M Lopa S S Sadik G | 2005 | Fitoterapia2005，76，78： | 1 |
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