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| 1 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 2 | Human neoplasms elicit multiple spcific immune rsponses in the autologous host 显示文摘 | Sahin U Tureci O Schmitt H | 1995 | Proc Natl Acad Sci USA1995，92，11： | 2 |
| 3 | Human neoplasms elicit multiple specific immune responses in the autologous host 显示文摘 | Sahin U Tureci O Schmitt H | 1995 | Proc NatlAcad Sci USA1995，92，11： | 2 |
| 4 | Zinc supplementation alleviates heat stress in laying Japanese quail显示文摘 | SAHIN K KUCUK O | 2003 | Journal of Nutrition2003，33，： | 1 |
| 5 | Comparison betweenlow flow sevoflurane anesthesia and total intravenous anesthe-sia during intermediate-duration surgery:effects on renal andhepatic toxicity显示文摘 | Sahin S H Cinar S O Paksoy I | 2011 | Hippokratia2011，15，1： | 1 |
| 6 | The importance of internet usage for urologic patients显示文摘 | Sahin C Tuncer M Yazici O | 2014 | Arch Ital Urol Androl2014，86，4： | 1 |
| 7 | Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure显示文摘 | Luo N Pereira S Sahin O | 2005 | Proc Natl Acad Sci USA2005，102，3： | 1 |
| 8 | Effects of chromium and ascorbic acid supplementation on growth, carcass traits, serum metabolites, and antioxidant statu; of broiler chickens reared at a high ambient temperature (32℃) 显示文摘 | Sahin K Sahin B Kucuk O | 2003 | Nutrition Research2003，23，： | 1 |
| 9 | Human neoplasms elicit multiple specific immune responses in the autologous host显示文摘 | Sahin U Tureci O Pfreundschuh M | 1995 | Proc Natl Acad Sci USA1995，92，11： | 1 |
| 10 | A novel method for pulmonary embolism detection in CTA images显示文摘 | zkan H Osman O Sahin S | 2014 | Comput Methods Programs Biomed2014，113，3： | 1 |
| 11 | SSX: a multigene family with several members transcribed in normal testis and human cancer 显示文摘 | Gure AO Tureci O Sahin U | 1997 | Int J Cancer1997，72，6： | 1 |
| 12 | Differences in automatic activity in individuals with optimal,normal,and high-normal blood pressure levels显示文摘 | DOGRU MT SIMSEK V SAHIN O | 2011 | Turk Kardiyol Dern Ars2011，38，3： | 1 |
| 13 | Abrasive wear behaviour of austempered ductile iron 显示文摘 | SAHIN Y DURAK O | 2007 | Materials and Design2007，28，： | 1 |
| 14 | Risk factors for infection of the diabetic foot with multi-antibiotic resistant microorganisms显示文摘 | Kandemir O Akbay E Sahin E | | 0，，05： | 1 |
| 15 | Effects of vitamin C and vitamin E on lipid peroxidation status, serum hormone, metabolite, and mineral concentrations of Japanese quails reared under heat stress (34℃) 显示文摘 | Sahin K Kucuk O Sahin N | 2002 | Int J Vitam Nutr Res2002，72，2： | 1 |
| 16 | Role of dietary zinc in heat-stressed poultry: a review显示文摘 | SAHIN K SAHIN N KUCUK O | 2009 | Poultry Science2009，88，10： | 1 |
| 17 | Human neoplasms elicit multi- ple specific immune responses in the autologous host 显示文摘 | Sahin U Tureci O Schmitt H | 1995 | Proc Natl Acad Sci U S A1995，92，11： | 1 |
| 18 | Strategic management of distressed inventory显示文摘 | Gallego G Phillips R Sahin (O) | | 0，，04： | 1 |
| 19 | Differences in automatic activity in individuals with optimal,normal and high-normal blood pressure levels显示文摘 | Dogru MT Simsek V Sahin O | 2010 | Turk Kardiyel Dern Ars2010，38，3： | 1 |
| 20 | Ureterosopic treatment of ureteral lithiasis with pneumatic lithotripsy analysis of 287 procedures in a public hospital显示文摘 | CEYLAN K SUNBUL O SAHIN A | 2005 | Uml Res2005，33，6： | 1 |
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