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| 1 | 新疆出血热病毒分子流行病学研究显示文摘目的研究新疆出血热病毒(XHF)分子流行病学,揭示其与相关病毒之间关系,分析XHF的流行来源和分布特点。方法RTPCR检测20012002年XHF患者和蜱标本中XHF病毒S基因,阳性标本直接进行核苷酸序列测定。计算机软件进行S基因部分片段和S全基因序列同源性比较和S基因、M基因的种系发生树分析。结果不同年份人和蜱来源的病毒S基因部分片段核苷酸序列均显示较高同源性(97.3%~100%)。S基因进化树分析将病毒分成了欧洲、非洲和亚洲3组,其中亚洲毒株由中亚分离株和中国分离株组成,中国所有的XHF病毒S基因(同源性93.0%~99.5%)均集中在一个分枝下形成独立的一组,明显区别于世界上其他地区分离株(同源性81.40%~96.4%)。M基因进化树分析表明序列间差异不完全与病毒分离的地理区域相关。结论S基因分析显示XHF病毒蜱分离株与人分离株遗传背景接近,我国XHF病毒有共同的进化途径和基因结构特点,并具明显的地域性。 | 唐青 赵秀芹 王环宇 司马义巴吾东 张玉贞 Masayuki Saijo Shigeru Morikawa 梁国栋 Ichiro Kurane | 2005 | 中华实验和临床病毒学杂志2005，19，4： | 11 |
| 2 | H pylori seropositivity and cytokine gene polymorphisms显示文摘AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to influence infection with H pylori.METHODS: The subjects were 410 Japanese transit company employees. C-reactive protein and conventional cardiovascular risk factors were evaluated. Serum anti-H pylori antibodies were measured. The genotypes of IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G polymorphisms were determined by allelic discrimination using fluorogenic probes and a 5′nuclease assay.RESULTS: In gender- and age-adjusted logistic analyses, the subjects with TNF-857T/T had a significantly lower odds ratio (OR) for H pylori seropositivity (reference -857C/C; OR = 0.15, 95% CI: 0.03-0.59, P = 0.007). After stratification according to smoking and drinking status, among never-smokers, the subjects with IL1B-511C/T had a significantly lower OR (reference -511C/C; OR = 0.30, 95% CI: 0.10-0.90, P = 0.032). Among drinkers in the 1-5 times/wk category, the subjects with IL1B-511T/T had a significantly lower OR (reference C/C; OR = 0.38, 95% CI: 0.16-0.95, P = 0.039), and the subjects with IL1B-31C/T and T/T had a significantly higher OR (reference C/C; C/T: OR = 2.59, 95% CI, P = 0.042: 1.04-6.47; C/C: OR = 3.17, 95% CI: 1.23-8.14, P = 0.017). Among current smokers, the subjects withIL6-634C/G had a significantly higher OR (reference C/C; OR = 2.28, 95% CI: 1.13-4.58, P = 0.021). However, the interactions terms between the aforementioned genotypes and lifestyles were not statistically significant.CONCLUSION: Contrary to previous findings, the results herein suggest that the TNF-857T/T genotype may be protective against chronic infection with H pylori. Drinking and smoking habits may influence the effect of cytokine gene polymorphisms. Further studies are required to clarify the effects of the pro- and anti-inflammatory cytokine polymorphisms and gene-environmental interactions on H pylori infection. | Yasuaki Saijo Eiji Yoshioka Tomonori Fukui Mariko Kawaharada Fumihiro Sata Hirokazu Sato Reiko Kishi | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 3 | ELECTROPLATED Zn-Ni-SiO_2 COMPOSITE COATINGS TREATED WITH A SILANE COUPLING AGENT TO REPLACE CHROMATING显示文摘The fixing of a silane coupling agent to Zn-Ni-silica (SiO2) composite coatings was studied for the purpose of developing a coating process as an alternative to chromating. The corrosion resistance of Zn-Ni-silica composite coatings was rem arkably improved by the silica nanoparticles in the composite, which were disper sed in the surface of this film. The silane coupling agent formed chemical bonds with the inorganic silica particles during the silane coupling treatment on the se composite coatings. The treatment suppressed the formation of white corrosion products to the same extent as chromating, as measured in salt spray tests. It is concluded that treating Zn-Ni-silica composite coatings with silane coupling agents is a viable alternative technique to chromating. | M. Hino M. Hiramatsu K. Murakami A. Saijo T. Kanadani | 2005 | Acta Metallurgica Sinica(English Letters)2005，18，3： | 4 |
| 4 | Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients显示文摘基因机制作为一些男不孕的一个原因被含有,还糟糕被理解。成熟分裂为复制对细菌房间和必需品唯一。synaptonemal 建筑群是为染色体配对,分离和再结合的一个批评部件。因为猛烈雄的老鼠是不肥沃的, Hormad1 为哺乳动物的 gametogenesis 是必要的。在早 pachytene 阶段和 synaptonemal 建筑群的 Hormad1 缺乏的睾丸展览 meiotic 拘捕不能被设想。为了分析人的 HORMAD1 基因缺点与人的精子缺乏被联系的假设,由 meiotic 拘捕引起了, mutational 分析被诊断,精子缺乏源于 meiotic 的 30 个日本人的直接顺序分析在所有编码区域执行拘捕。由顺序分析,三个多型性地点,单个核苷酸多型性 1 (c。163A > G ) , SNP2 (c。501T > G ) 并且 SNP3 (c。918C > T ) ,在 exons 被发现 3, 8 和 10。有精子缺乏和 80 个正常的证明怀孕的、肥沃的人的 30 个病人为 HORMAD1 多型性被分析。SNP1 和 SNP2 与人的精子缺乏由完全的早 meiotic 拘捕引起了被联系(P< 0.05 ) 。我们建议 HORMAD1 让必要 meiotic 在人的精子发生工作。 | Toshinobu Miyamoto Aldra Tsujimura Yasushi Miyagawa Eitetsu Koh Mikio Namiki Michiharu Horikawa Yasuaki Saijo Kazuo Sengoku | 2012 | Asian Journal of Andrology2012，14，4： | 3 |
| 5 | ENVIRONMENTAL FRIENDLY ANODIZING ON AZ91D MAGNESIUM ALLOYS AND COATING CHARACTERISTICS显示文摘An environmental friendly anodizing treatment (Anomag) from a phosphate-based so lution without heavy metals on AZ91D magnesium alloy was studied. The characteri stics of the coatings, such as structure, composition and corrosion resistance w ere investigated. The effects of this anodizing treatment on the mechanical prop erties were examined. X-ray diffraction (XRD) analysis revealed that the structu re of the coatings is amorphous or glassy. In salt spray tests coatings with an average thickness of 10μm had an anticorrosive performance of over 1000 hours. Fatigue tests revealed that anodizing onto AZ91D magnesium alloy does not affect the fatigue strength. These results demonstrate the utility of this anodizing t reatment on magnesium alloy for application as a structural material, such as in the automotive field. | A. Saijo M. Hino M. Hiramatsu T. Kanadani | 2005 | Acta Metallurgica Sinica(English Letters)2005，18，3： | 3 |
| 6 | Mechanisms Underlying Inflammation in Neurodegeneration显示文摘 | Christopher K. Glass Kaoru Saijo Beate Winner Maria Carolina Marchetto Fred H. Gage | 2010 | Cell2010，，6： | 3 |
| 7 | Current Status of Pylorus-Preserving Gastrectomy for the Treatment of Gastric Cancer: A Questionnaire Survey and Review of Literatures显示文摘 | Chikashi Shibata Fumito Saijo Masayuki Kakyo Makoto Kinouchi Naoki Tanaka Iwao Sasaki Takashi Aikou | 2012 | World Journal of Surgery2012，，4： | 2 |
| 8 | On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease显示文摘 | Fumito Saijo Alexandra B. Milsom Nathan S. Bryan Selena M. Bauer Thorsten Vowinkel Marina Ivanovic Chris Andry D. Neil Granger Juan Rodriguez Martin Feelisch | 2009 | Nitric Oxide2009，，2： | 2 |
| 9 | Gallic acid esters of bergenin and norbergenin from Mallotus japonicus 显示文摘 | Saijo R Nonaka G I Nishioka I | 1990 | Phytochemistry1990，29，1： | 1 |
| 10 | Relationship between C-reactive protein andvis ceral adipose tissue in healthy Japanese subjects显示文摘 | Saijo Y Kiyota N | 2004 | Diabetes Obes Metab2004，6，4： | 1 |
| 11 | Randomized trial of cyclophosphamide,doxorubicin,and vincristine versus cisplatin and etoposide versus alternation of these regiments in small cell lung cancer显示文摘 | Fukuoka M Furuse K Saijo N | 1991 | JNCI1991，83，： | 1 |
| 12 | Majocchi's disease in a newborn baby: a familial case显示文摘 | Honda M Saijo S Tagami H | 1997 | Br J Dermatol1997，137，4： | 1 |
| 13 | Development ofrecombinant nucleoprotein-based diagnostic systems forLassa fever显示文摘 | Saijo M Marie C Georges C | 2007 | Clin Vaccine Immunol2007，14，9： | 1 |
| 14 | Disparities in gastric cancer chemotherapy between the East and West显示文摘 | Ohtsu A Yoshida S Saijo N | 2006 | Clini Oneol2006，24，： | 1 |
| 15 | Platinum compounds in cancer therapy-past,present,and future显示文摘 | Akaza H Saijo N Aiba K | | 0，，： | 1 |
| 16 | The roles of IL-17A in in- flammatory immune responses and host defense against pathogens 显示文摘 | Iwakura Y Nakae S Saijo S | 2008 | Immunol Rev2008，226，1： | 1 |
| 17 | Immunology:oxysterols hold T cells in check显示文摘 | GLASS C K SAIJO K | 2008 | Nature2008，455，： | 1 |
| 18 | Reasons for response differences seen in the V 15 32 INTEREST and IPASS trials显示文摘 | Saijo N Takeuchi M Kunitoh H | 2009 | Nat Rey Clin Onco2009，6，5： | 1 |
| 19 | Diagnosis and molecular analysis ofthree male patients with thiamine-responsive pyruvate dehydrogenase complex deficiency显示文摘 | Naito E Ito M YokotaI Saijo T Ogawa Y Kuroda Y | 2002 | J Neurol Sci2002，201，12： | 1 |
| 20 | Genetic factors in fetal growth restriction and miscarriage显示文摘 | Yamada H Sata F Saijo Y | 2005 | Semin Thromb Hemost2005，31，3： | 1 |
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