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| 1 | STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury显示文摘AIM To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODS We investigated thioacetamide(TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma(HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAAinduced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9(SOX9) and Yes-associated protein(YAP), which regulate the transdifferentiation of hepatocytes to cholangiocytes.RESULTS Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic STAT3-deficient mice as compared with control mice. STAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic STAT3-deficient livers as compared with control livers. SOX9 and YAP were upregulated in hepatic STAT3-deficient hepatocytes.CONCLUSION STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration. | Mitsuhiko Abe Takafumi Yoshida Jun Akiba Yu Ikezono Fumitaka Wada Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Hideki Iwamoto Toru Nakamura Michio Sata Hironori Koga Akihiko Yoshimura Takuji Torimura | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 2 | Immunohistochemical localization of gamma-aminobutyric acid (GABA) in the rat pancreas显示文摘 | M. Sakaue N. Saito C. Tanaka | 1987 | Histochemistry1987，，4： | 2 |
| 3 | Mechanism of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity显示文摘 | RASHID S WATANABE T SAKAUE T | 2003 | Clinical Biochemistry2003，36，6： | 2 |
| 4 | RBP4, an unexpected adipo-kine显示文摘 | Tamori Y Sakaue H Kasuga M | 2006 | Nat Med2006，12，2： | 1 |
| 5 | DNA Methylation is dispensable for the growth and survival of the extraembryonic lineages显示文摘 | SAKAUE M OHTA H KUMAKI Y | 2010 | Current Biology2010，20，16： | 1 |
| 6 | Changes in the anterior chamber configuration after small - incision cataract surgery with posterior chamber intraocular lens implantation 显示文摘 | Kurimoto Y Park M Sakaue H | 1997 | Am J Ophthalmul1997，124，6： | 1 |
| 7 | Simulaneous pattern reversal ERG and VEP recordings effect of stimnlus field and central scotoma显示文摘 | Sakaue H Katsumi O Mehta M | 1990 | Imest Ophthalmol Vis Sci1990，31，： | 1 |
| 8 | Purification and character- ization of monoamine oxidase from Klebsiella aerogenes显示文摘 | Yamashita M Sakaue M Iwata M | 1993 | Journal of Fermentation and Bioengineering1993，76，4： | 1 |
| 9 | NF - KB decoy sup- presses cytokine expression and thermal hyperalgesia in a rat neu- ropathic pain model 显示文摘 | Sakaue G Shimaoka M Fukuoka T | 2001 | Neuroreport2001，12，10： | 1 |
| 10 | Bisphenol A affects spermatogenesis in the adult rat even at a low dose显示文摘 | Sakaue M Ohsako S Ishimura R | 2001 | J Occup Health2001，43，： | 1 |
| 11 | Changes in the anteriorehamber configuration after small-incision cataract surgery with posterior chamber intraocular lens implantation 显示文摘 | Kurimoto Y Park M Sakaue H | 1997 | Am J Ophthalmol1997，124，： | 1 |
| 12 | Optimization of anodized- aluminum pressure-sensitive paint by controlling luminophore concen- tration 显示文摘 | Sakaue H Ishii K | 2010 | Sensors2010，10，7： | 1 |
| 13 | Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity显示文摘 | Rashid S Watanabe T Sakaue T el al | 2003 | Clin Biochem2003，36，6： | 1 |
| 14 | Kinetics of endotoxinconcentration and tumor necrosis factor-alpha,interleukin-1 beta,andinterleukin-6 activities in the systemic and portal circulation duringsmall intestinal ischemia and reperfusion in dogs显示文摘 | NezuY Tagawa M Sakaue Y | 2002 | Am J Vet Res2002，63，： | 1 |
| 15 | Changes in anterior chamber configuration after small incision cataract surgery with posterior chamber intraocular lens implantation 显示文摘 | Kurimoto Y Park M Sakaue H | 1997 | Am J Ophthalmol1997，124，： | 1 |
| 16 | Analysis of N-glycan in serum glycoproteins from db/db mice and humans with type 2 diabetes显示文摘 | ITOH N SAKAUE S NAKAGAWA H | 2007 | Am J Physiol Endocrinol Metab2007，293，4： | 1 |
| 17 | Changes in the anterior chamber configuration after small-incision cataract surgery with posterior chamber intraocular lens implantation显示文摘 | Kurimoto Y Park M Sakaue H | | 0，，06： | 1 |
| 18 | Low - dose candesartan cilexetil prevents early kidney damage in type 2 diabetic patients with mildly elevated blood pressure 显示文摘 | Murayama S Hirano T Sakaue T | 2003 | Hypertens Res2003，26，6： | 1 |
| 19 | Effect of maternal exposure to low doses of DES on testieular steroidogenesis and spermatogenesis in male rat offspring 显示文摘 | KOBAYASHI T SHIRAI M SAKAUE M | 2009 | Reproduction and Development2009，55，6： | 1 |
| 20 | Diet-Induced Up-Regula- tion of Gene Expression in Adipocytes Without Changes in DNA Methylation 显示文摘 | Okada Y Sakaue H Nagare T | 2008 | Kobe J Med Sci2008，54，： | 1 |
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