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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Drug-eluting coronary stents显示文摘 | Suwaidi JA Holmes DR | 2006 | Curr Probl Cardiol2006，31，： | 1 |
| 3 | Evolving role of clopidogrel in acute coronary syndromes显示文摘 | Salam AM Al Suwaidi J | 2005 | Expert Rev Cardiovasc Ther2005，3，6： | 1 |
| 4 | Multi-detector dental CT in evaluation of impacted maxillary canine显示文摘 | Salam E El-Badrawy A Tawfik AM | 2012 | The Egyptian Journal of Radiology and Nuclear Medicine2012，43，4： | 1 |
| 5 | Evolving role of clopidogrel in acute coronary syndromes显示文摘 | Salam AM Alsuwaidi J | 2005 | Expert Rev Cardiovasc Ther2005，3，6： | 1 |
| 6 | Intensive lipid-lowering therapy in coronary artery disease; implications of the REVERSAL and PROVE-IT trials显示文摘 | Salam AM | 2004 | Expert Opin Investig Drugs2004，13，6： | 1 |
| 7 | Acute myocardial infarction in a professional diver after jellyfish sting显示文摘 | Salam AM Albinali HA Gehani AA | 2003 | Mayo Clinic Proceedings2003，78，12： | 1 |
| 8 | Cohesiveness and flowability properties of silica gel powder 显示文摘 | Abdullah EC Salam AM Raman AAA | 2010 | Phys Intl2010，1，1： | 1 |
| 9 | Contrast-enhanced 64 -section coronary multideteetor CT angiography versus conventional coronary angiography for stent assessment 显示文摘 | Das KM E1-Menyar AA Salam AM | 2007 | Radiology2007，245，2： | 1 |
| 10 | The therapeutic potential of ximelagatran of choice in medicine:a review of recently completed clinical trials 显示文摘 | Salam AM AL-Mousa EN | 2004 | Expert Opin Pharmacother2004，5，6： | 1 |
| 11 | Contrast-enhanced 64- section coronary muhidetector CT angiography versus conventional coronary angiography for stent assessment 显示文摘 | Das KM E1-Menyar AA Salam AM | 2007 | Radiology2007，245，2： | 1 |
| 12 | Contrast-enhanced 64-sec-tion coronary multidetector CT angiography versus conventional coronary angiography for stent assessment 显示文摘 | Das KM EI-Menym' AA Salam AM | 2007 | Radiology2007，245，2： | 1 |
| 13 | Prevalence of coronary artery disease assessed by multislice computed tomography coronary angiography inpatients with paroxysmal or persistent atrial fibrillation 显示文摘 | Salam AM Gersh B J A1Binali HA | 2009 | Cire Cardiovasc Imaging2009，2，： | 1 |
| 14 | Contrast-enhanced 64-section coronary multidetector CT angiography versus conventional coronary angiography for stent assessment显示文摘 | Das KM El-Menyar AA Salam AM | 2007 | Radiology2007，245，1： | 1 |
| 15 | Multi-detector dental CT in evaluation of impacted maxillary canine显示文摘 | Salam EA Badrawy AE Tawfik AM | 2012 | Egy J R adiol Nuc Med2012，43，4： | 1 |
| 16 | Evolving role of clopidogrel in acute coronary syndromes显示文摘 | Salam AM Suwaidi J | 2005 | Expert Rev Cardiovasc Ther2005，3，6： | 1 |
| 17 | Relationship between head posture and h yoid position in adult females and males 显示文摘 | Sahin Salam AM Uydas NE | 2006 | J Craniomaxillofac Surg2006，34，2： | 1 |
| 18 | Contrast-enhanced 64-section coronary multidetector CT angiography versus conventional coronary angiography for stent assessment显示文摘 | Das KM El-Menyar AA Salam AM | 2007 | Radiology2007，245，2： | 1 |
| 19 | Intensive lipid - lowering therapy in coronary artery disease implications of the REVERSAL and PROVE - IT trials 显示文摘 | Salam AM | 2004 | Expert Opin Investig Drugs2004，13，： | 1 |
| 20 | Evolving role of clopidogrel in acute coronary syndromes 显示文摘 | Salam AM AI suwaidi J | 2005 | Expert Rev Cardiovasc Ther2005，3，6： | 1 |
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