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| 1 | Anti-HBc screening in Indian blood donors:Still an unresolved issue显示文摘AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed. | Hari Krishan Dhawan Neelam Marwaha Ratti Ram Sharma Yogesh Chawla Beenu Thakral Karan Saluja Sanjeev Kumar Sharma Manish K Thakur Ashish Jain | 2008 | World Journal of Gastroenterology2008，14，34： | 8 |
| 2 | Gastric conduit perforation显示文摘As patients with carcinoma of the esophagus live longer, complications associated with the use of a gastric conduit are increasing. Ulcers form in the gastric conduit in 6.6% to 19.4% of patients. There are a few reports of perforation of a gastric conduit in the English literature. Almost all of these were associated with serious complications. We report a patient who developed a tension pneumothorax consequent to spontaneous perforation of an ulcer in the gastric conduit 7 years after the index surgery in a patient with carcinoma of the gastroesophageal junction. He responded well to conservative management. Complications related to a gastric conduit can be because of multiple factors. Periodic endoscopic surveillance of gastric conduits should be considered as these are at a higher risk of ulcer formation than a normal stomach. Long term treatment with proton pump inhibitors may decrease complications. There are no guidelines for the treatment of a perforated gastric conduit ulcer and the management should be individualized. | Nilesh Patil Arvind Kaushal Amit Jain Sundeep Singh Saluja Pramod Kumar Mishra | 2014 | World Journal of Clinical Cases2014，2，8： | 4 |
| 3 | Management of splenic artery aneurysm associated with extrahepatic portal vein obstruction显示文摘BACKGROUND: Splenic artery aneurysms although rare are clinically significant in view of their propensity for spontaneous rupture and life-threatening bleeding. While portal hypertension is an important etiological factor, the majority of reported cases are secondary to cirrhosis of the liver. We report three cases of splenic artery aneurysms associated with extrahepatic portal vein obstruction and discuss their management. METHODS: The records of three patients of splenic artery aneurysm associated with extrahepatic portal vein obstruction managed from 2003 to 2010 were reviewed retrospectively. The clinical presentation, surgical treatment and outcome were analyzed. RESULTS: The aneurysm was >3 cm in all patients. The clinical symptoms were secondary to extrahepatic portal vein obstruction (hematemesis in two, portal biliopathy in two) while the aneurysm was asymptomatic. Doppler ultrasound demonstrated aneurysms in all patients. A proximal splenorenal shunt was performed in two patients with excision of the aneurysm in one patient and ligation of the aneurysm in another one. The third patient had the splenic vein replaced by collaterals and hence underwent splenectomy with aneurysmectomy. All patients had an uneventful post-operative course. CONCLUSIONS: Splenic artery aneurysms are associated with extrahepatic portal vein obstruction. Surgery is the mainstay of treatment. Although technically difficult, it can be safely performed in an experienced center with minimal morbidity and good outcome. | Pramod Kumar Mishra Sundeep Singh Saluja Ashok K Sharma Premanand Pattnaik | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 4 |
| 4 | Pathogenic mechanisms of acute pancreatitis显示文摘 | Raghuwansh P. Sah Pramod Garg Ashok K. Saluja | 2012 | Current Opinion in Gastroenterology2012，，5： | 2 |
| 5 | New insights into the pathogenesis of pancreatitis显示文摘 | Raghuwansh P. Sah Rajinder K. Dawra Ashok K. Saluja | 2013 | Current Opinion in Gastroenterology2013，，5： | 2 |
| 6 | Pathogenic mechanisms of acute pancreatitis显示文摘 | Raghuwansh P. Sah Pramod Garg Ashok K. Saluja | 2012 | Current Opinion in Gastroenterology2012，，5： | 2 |
| 7 | Acute Pancreatitis: Bench to the Bedside显示文摘 | Stephen J. Pandol Ashok K. Saluja Clement W. Imrie Peter A. Banks | 2007 | Gastroenterology2007，，3： | 2 |
| 8 | Prevalence of and risk factors for depressive symptoms among young adolescents 显示文摘 | Saluja G Iachan R Scheidt P C | 2004 | Arch Pediatr Adolesc Med2004，158，8： | 1 |
| 9 | PPAR delta agonists stimuLate oligodendrocyte differentiation in tissue culture 显示文摘 | Saluja I Granneman J Skoff R | 2001 | Glia2001，33，3： | 1 |
| 10 | Detection of Neisseria gonorrhoeae by PCR using orf1 gene as target显示文摘 | Chaudhry U Saluja D | | 0，，： | 1 |
| 11 | Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB/c mice显示文摘 | Amorij J P Saluja V Petersen A H | 2007 | Vaccine2007，25，52： | 1 |
| 12 | A Tutorial on Built-In Self-Test, part 1: Principles显示文摘 | V D Agrawal C R Kime K K Saluja | 1993 | IEEE Design and Test of Computers1993，10，2： | 1 |
| 13 | In vivo evidence for the role of GM-CSF as a mediator in acute pancreatitis-associated lung injury显示文摘 | Frossard JL Saluja AK Mach N | 2002 | Am J Physiol Lung Cell Mol Physiol2002，283，3： | 1 |
| 14 | Relationship between severerity, necrosis and apoptosis in five models of experimental acute pancreatitis显示文摘 | Kaiser AM Saluja AK | 1995 | Am J Physiol1995，269，5： | 1 |
| 15 | Pathophysiology of pancreatitis显示文摘 | Ashok K Saluja ML Steer | 1999 | Digestion1999，，： | 1 |
| 16 | A Comparison Between Spray Drying and Spray Freeze Drying To Pro- duce an Influenza Subunit Vaccine Powder for Inhalation 显示文摘 | SALUJA V AMORIJ J P KAPTEYN J C | 2010 | J Control Release2010，144，2： | 1 |
| 17 | Detection of Neisseria gonorrhoeae by PCR using orfl gene as target显示文摘 | Chaudhry U Saluja D | | 0，，： | 1 |
| 18 | An efficient algorithm for sequential circuits test generation 显示文摘 | Kelsey T P Saluja K K Lee S Y | 1993 | IEEE Trans Computers1993，42，11： | 1 |
| 19 | Effect of recombinant platelet-activating factor acetylhydrolase on two models of experimental acute pancreatitis 显示文摘 | Hofbauer B Saluja A K Bhatia M | 1998 | Gastroenterology1998，115，5： | 1 |
| 20 | Why does pancreatic overstimulation cause pancreatitis? 显示文摘 | Saluja A K Lerch M M Phillips P A | 2007 | Annu Rev physiol2007，69，： | 1 |
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