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| 1 | Liver stiffness as a predictor of hepatocellular carcinoma behavior in patients with hepatitis C related liver cirrhosis显示文摘Background: Risk strati cation and prognostication of hepatocellular carcinoma (HCC) help to improve patient outcome. Herein we investigated the role of liver stiffness measurement (LSM) in the prediction of HCC behavior. Methods: Totally 121 na ve patients with HCC were included. HCC radiological evaluation and staging were done. LSM was measured using virtual touch quanti cation. Patients were divided into early to intermediate HCC (BCLC-0, A and B) and late HCC (BCLCC and D). HCC was treated according to the BCLC stage. HCC recurrence-free interval was estimated. Results: The mean LSM inside the tumor was signi cantly lower than the peri-tumoral area and the cirrhotic non-cancerous liver parts (P<0.001). In late HCCs stage, the mean LSM inside the tumor and in the peri-tumoral tissue was lower than the corresponding values in the early to intermediate HCCs stage (P<0.001). LSM inside the tumor and in the peri-tumoral tissue negatively correlated with serum AFP, tumor vascular invasion, and stage (P<0.05). The recurrence-free interval was directly correlated to LSM inside the tumor and inversely to LSM in cirrhotic non tumorous liver part. Kaplan-Meier analysis showed that the recurrence-free interval was signi cantly longer in patients with LSM inside the tumor of ≥1.25m/s compared to those with LSM inside the tumor of<1.25m/s. Conclusions: LSM can serve as a potential non-invasive predictor for HCC clinical behavior and the recurrence-free interval following loco-regional treatments. | Sameh A Lashen Mohamed M Elshafei Fahmy H Hablass Eman A Alsayed Asmaa A Hassan | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 4 |
| 2 | Waveform se- lection in radar target classification 显示文摘 | Sameh M Sowelam Ahmed H Tewfik | 2000 | IEEE trans- action on information theory2000，46，3： | 1 |
| 3 | Electrically addressable hybrid architectures of zinc oxide nanowires grown on aligned carbon nanotubes 显示文摘 | Jong G Ok Sameh H Tawfick Anne Juggernauth K | 2010 | Adv Funct Mater2010，20，： | 1 |
| 4 | A trace minimization algorithm for The generalized eigenvalue problem compuations显示文摘 | SAMEH A H WISNIEWSKI J A | 1982 | SIAM Journal on Numerical Analysis1982，19，： | 1 |
| 5 | Preconditioning techniques for nonsymmetric linear systems in the computation of incompressible flows 显示文摘 | Manguoglu M Sameh A H Saied F | 2009 | Journal of Applied Mechanics2009，76，2： | 1 |
| 6 | Carbon nanotubes:present and future commercial applications显示文摘 | Michael F L De Volder Sameh H | 2013 | Science2013，339，： | 1 |
| 7 | Influence of diffusive transport on the structural evolution of W/O/W emulsions 显示文摘 | SAMEH H WAFA E SIHEN B | 2012 | Langmuir2012，28，17： | 1 |
| 8 | Numerical linear algebra algorithms on the cedar system 显示文摘 | Chen Hsin Chu Sameh A H | 1987 | Parallel Computations and Their Impact on Mechanics1987，86，1： | 1 |
| 9 | Crossover from single-step tunneling to multi-step hopping for molecular triplet energy transfer 显示文摘 | Josh V W Sameh H A Ruchi S | 2010 | Science2010，328，5985： | 1 |
| 10 | Seismic Response of Slab-Column Connections Constructed with High-Strength Concrete显示文摘 | Mohamed Eman Marzouk H and Sameh Hilal M | 1997 | ACI Structural Journal1997，94，2： | 1 |
| 11 | A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties显示文摘 | Sameh S A Joshua I H Kevin L D | 2004 | Free Radical Biolog&Medicine2004，37，8： | 1 |
| 12 | A matrix decomposition method for orthotropic elasticity problems显示文摘 | Chen H C Sameh A | 1989 | SIAM J Matrix Anal Appl1989，10，： | 1 |
| 13 | A matrix decomposition method for orthotropic elasticity problems显示文摘 | CHEN H C SAMEH A | 1989 | SIAM J Matrix Anal Appl1989，10，： | 1 |
| 14 | Genomic diversity of colorectal cancer: Changing landscape and emerging targets显示文摘Improvements in screening and preventive measures have led to an increased detection of early stage colorectal cancers(CRC) where patients undergo treatment with a curative intent. Despite these efforts, a high proportion of patients are diagnosed with advanced stage disease that is associated with poor outcomes, as CRC remains one of the leading causes of cancer-related deaths in the world. The development of next generation sequencing and collaborative multiinstitutional efforts to characterize the cancer genome has afforded us with a comprehensive assessment of the genomic makeup present in CRC. This knowledge has translated into understanding the prognostic role of various tumor somatic variants in this disease. Additionally, the awareness of the genomic alterations present in CRC has resulted in an improvement in patient outcomes, largely due to better selection of personalized therapies based on an individual's tumor genomic makeup. The benefit of various treatments is often limited, where recent studies assessing the genomic diversity in CRC have identified the development of secondary tumor somatic variants that likely contribute to acquired treatment resistance. These studies have begun to alter the landscape of treatment for CRC that include investigating novel targeted therapies, assessing the role of immunotherapy and prospective, dynamic assessment of changes in tumor genomic alterations that occur during the treatment of CRC. | Daniel H Ahn Kristen K Ciombor Sameh Mikhail Tanios Bekaii-Saab | 2016 | World Journal of Gastroenterology2016，22，25： | 0 |
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