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| 1 | Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years. | Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer | 2014 | World Journal of Gastroenterology2014，20，7： | 5 |
| 2 | A randomized control trial of cell salvage in routine cardiac surgery显示文摘 | Klein A Samer A Sharples L | | 0，，： | 1 |
| 3 | Alkaline earth complexes of 1,4,7,10-tetrakis(2-hydroxycthyl)-and 1,4,7,10-tetrakis(2-methoxyethyl)-1,4,7,10-tetraazacyclododecane;an equilibrium and kinetic study显示文摘 | Ramesh D Stephen F L Samer M | 2000 | Inorg Chem2000，39，： | 1 |
| 4 | Cefepime in vitro activity against derepressed extended-spectrum β-lactamases (ESBLs)-producing and non-ESBLs-producing Enterobacter cloacae by a disc diffusion method显示文摘 | Naumiuk L Samer A Dziemaszkiewicz E | 2001 | J Antimicrob Chemother2001，48，： | 1 |
| 5 | Microleakage of compomer Class V restorations:Effect of load cycling, thermal cycling, and cavity shape differences显示文摘 | ]Samer Hakimeh Jayalakshmi Vadyanathan Milton L Houpt | 2000 | J Prosthet Dent2000，83，2： | 1 |
| 6 | Knowledge Collaboration in Online Communities显示文摘 | Samer Faraj Sirkka L Jarvenpaa Ann Majchrzak | | 0，，05： | 1 |
| 7 | A randomized control trial of cell salvage in routine cardiac surgery显示文摘 | Klein A Samer A Sharpies L | | 0，，： | 1 |
| 8 | Cefepime in vitro activity against derepressed extended-spectrum β-lactamase (ESBL)-producing and non-ESBL-producing Enterobacter cloacae by a discdiffusion method显示文摘 | SAMER A DZIEMASZKIEWICZ E | 2001 | J Antimicrob Chemother2001，48，： | 1 |
| 9 | The compatibility of Hly factor, a transmissible element that controls alpha-hemolysin production in Escherichia coli显示文摘 | Monti-Bragadin C Samer L Rottini G | 1975 | J Gen Microbiol1975，86，2： | 1 |
| 10 | Two-dimensional and three-dimensional finite element analysis of critical crack-tip-opening angle in 2024-T351 aluminum alloy at four thicknesses显示文摘 | Samer M Kevin L | 2004 | Engineering Fracture Mechanics2004，，71： | 1 |
| 11 | Comparison of Effectiveness of High-Dose Intracoronary Adenosine Versus Intravenous Administration on the Assessment of Fractional Flow Reserve in Patients With Coronary Heart Disease显示文摘 | Ramón López-Palop Pilar Carrillo Araceli Frutos Alberto Cordero Pilar Agudo Samer Mashlab Vicente Bertomeu-Martínez | 2013 | The American Journal of Cardiology2013，，： | 1 |
| 12 | Cefepime in vitro activity against depressed extended-spectrum β-lactamase-ESBL-producing and Non-ESBL-producing Enterobacter cloacae by a disc diffusion method显示文摘 | Naumiuk L Samer A Dziemakzkiewicz E | 2001 | Antimicrob chemother2001，48，： | 1 |
| 13 | Cefepime in vitro activity against derepressed extended-spectrum β- lactamases(ESBLs)-producing and non-ESBLs-producing Enterobacter cloacae by a dise diffusion method 显示文摘 | Naumiuk L Samer A Dziemaszkiewicn E | 2001 | J Antimicrob Chemother2001，48，2： | 1 |
| 14 | Clinical presentation and treatment of atrial ? brillation in Wolff-Parkinson-White syndrome显示文摘 | Joanne L Samer T | 2010 | Heart Lung2010，39，7： | 1 |
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