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| 1 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 2 | 走出教室,回归现实世界:用手机和增强现实技术传授科学课程显示文摘未来实验室的工作是研究如何使用最新的技术支持教育活动,我们跟学术界、政策决策者、教育家、学习者和技术专家们一起合作,找到这一问题的答案。 | Richard Sandford | 2011 | 科普研究2011，6，S1： | 3 |
| 3 | Polymorphisms in the IL-4,IL-4 RA and FCER IB genes and asthma severity显示文摘 | Sandford A Chagani T Zhu S | 2000 | J Allergy Clin Immunoc2000，106，1： | 1 |
| 4 | The Value of Serial Arteriography in Osteosarcoma: Delivery of Chemotherapy, Determination of Therapy Duration, and Prediction of Necrosis显示文摘 | John W. Cullen Brandt A. Jamroz Sidney L. Stevens Walt Madsen Ioana Hinshaw Ross M. Wilkins Patsy Cullen Anne B. Camozzi Kyle Fink Sandford D. Peck Cynthia M. Kelly | 2005 | Journal of Vascular and Interventional Radiology2005，，8： | 1 |
| 5 | Selection of reference genes for gene expression studies in human neutrophils by real-time PCR显示文摘 | Zhang Xiao-zhu Ding Li-ly Sandford AJ | 2005 | BMC Mol Bioi2005，6，： | 1 |
| 6 | The effects of antifreeze proteins on chilled and frozen meat显示文摘 | PAYNE S R SANDFORD D HARRIS A | 1994 | Meat Science1994，37，： | 1 |
| 7 | Determination of Chemical Oxygen Demand in Fresh Waters Using Flow Injection With On-line UV-photocatalytic Oxidation and Spectrophotometric Detection显示文摘 | DAN De-zhong SANDFORD R C WORSFOLD P J | 2005 | The Analyst2005，130，2： | 1 |
| 8 | Assessment of the interstellar processes leading to deuterium enrichment in meteoritic organics显示文摘 | Sandford S A Bernstein M P Dworkin J P | 2001 | Meteoritics&Planetary Science2001，36，： | 1 |
| 9 | Susceptibility genes for rapid decline of lung function in the lung health study显示文摘 | Sandford AJ Chagani T Weir TD | 2001 | Am J Respir Crit Care Med2001，163，2： | 1 |
| 10 | 显示文摘 | Sandford AJ Chagani T Weir TD | 2001 | Am Respir Crit Care Med2001，163，2： | 1 |
| 11 | A model for cystic endometrial hyperplasia/pyometra complex in the bitch显示文摘 | ARORA N SANDFORD J BROWNING G F | 2006 | Theriogenology2006，66，67： | 1 |
| 12 | Susceptibility genes for rapid decline of lung function in the lung health study 显示文摘 | Sandford A J Chagani T Weir TD | 2001 | Am J Respir Crit Care Med2001，163，2： | 1 |
| 13 | Aluminum Chloide Catalyzed Nitration of Aromatics with Sodium Nitrate/Chorotrimethylsilane显示文摘 | Ramaiah P Sandford G | 1994 | Synthesis1994，，： | 1 |
| 14 | IL -4 receptor genetic polymorphisms and asthma in Asian populations 显示文摘 | Zhang W Zhang X Qia D Sandford A Tan WC | 2007 | Respir Med2007，101，1： | 1 |
| 15 | Polymorphisms in the IL4, IL4RA,and FCERIB genes and asthma severity 显示文摘 | Sandford A J Chagani T Zhu S | 2000 | J Allergy Clin Immuno12000，106，： | 1 |
| 16 | Characterization of the pufferfish (Fugu) genome as a compact model verte- brate genome显示文摘 | Brenner S Elgar G Sandford T | 1993 | Nature1993，366，： | 1 |
| 17 | Improved symmetry greatly increases X-ray power from wire-array Z-pinches显示文摘 | Sandford T W L Allshouse G O Marder B M | 1996 | Phys Rev Lett1996，77，25： | 1 |
| 18 | Structural studies of gellan gum, an extracellular polysaccharide elaborated by Pseudo- monas elodea 显示文摘 | Jansson R E Lindberg B Sandford P I A | 1983 | Carbohydrate Research1983，124，1： | 1 |
| 19 | Characterization of the pufferfish (Fugu) genome as a compact model vertebrate genome 显示文摘 | Brenner S Elgar G Sandford R | 1993 | Nature1993，366，： | 1 |
| 20 | Organoflurine chemistry:Element fluorine in organic chemistry显示文摘 | Hutchinson J Sandford G | | 0，，： | 1 |
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