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| 1 | COVID-19 and neurologic manifestations:a synthesis from the child neurologist’s corner显示文摘Background Since December 2019,the SARS-CoV-2 virus has been a global health issue.The main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been reported.In this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric population affected by SARS-CoV-2 infection and the pandemic’s effects in children with neurologic diseases.Data sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic manifestations COVID-19,Neurological COVID-19,coronavirus,SARS-CoV-2,pediatric COVID-19,COVID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain BarréSyndrome,Stroke,ADEM,and Anti-NMDA encephalitis.All studies cited were published between 2004 and 2022,and represent the most relevant articles in the field.The World Health Organization COVID-19 online dashboard was assessed to obtain updated epidemiological data.Results The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle weakness.These can be present during COVID-19 or weeks after recovering from it.Children who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and mortality.Several neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated processes.On the other hand,the COVID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and therapies.Conclusions Various neurologic manifestations have been associated with children’s SARS-CoV-2 infection.It is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting sequelae.Different neuro-pathophysiological mechanisms have been proposed,however,a causal relationship between SARS-CoV-2 infection and neurologic manifestations remains to be proven.Patients with neurologic diseases are especially affected by COVID-19,not only by the disease itself but also by its complications and pandemic management measures. | Carolina Valderas Gastón Méndez Alejandra Echeverría Nelson Suarez Katherin Julio Francisca Sandoval | 2022 | World Journal of Pediatrics2022，18，6： | 2 |
| 2 | 生理性线粒体破碎是心脏适应能量需求增加的正常现象显示文摘线粒体在心脏中起着双重作用:负责满足能量需求和调节细胞凋亡。通常认为,线粒体的分裂和碎裂是病理性应激(如缺血)的结果,是线粒体质量差的指标,并导致线粒体自噬和细胞死亡。然而,最近的研究表明,抑制裂变也导致线粒体功能减弱和心脏损害,说明裂变对维持心脏和线粒体生物能量平衡十分重要。 | 刘莉 叶鹏 Coronado M Fajardo G Nguyen K Zhao M Kooiker KB Jung G Hu DQ Reddy S Sandoval E Stotland A Gottlieb RA Bernstein D | 2018 | 中华高血压杂志2018，26，1： | 2 |
| 3 | Effect of dietary zinc source andmethod of oral administration on performance and tissue tracemineral concentration of broiler chicks 显示文摘 | Sandoval M P R Henry R C Littell R D | 1999 | J Anim Sci1999，77，： | 1 |
| 4 | The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells:retrieval is disrupted in nephrotic states显示文摘 | Russo LM Sandoval RM McKee M | 2007 | Kidney Int2007，71，： | 1 |
| 5 | Impairedtubular uptake explains albuminuria in early diabetic nephropathy显示文摘 | RUSSO L M SANDOVAL R M CAMPOS S B | 2009 | J Am Soc Nephrol2009，20，3： | 1 |
| 6 | CREB: A key regulator of normal and neoplastic hematopoiesis 显示文摘 | Sandoval S Pigazzi M Sakamoto KM | 2009 | Adv Hematol2009，2009，63： | 1 |
| 7 | Antioxidant activity of the cruciferous vegetable Maca (Lepidium meyenii) 显示文摘 | SANDOVAL M OKUHAMA NN ANGELES FM | 2002 | Food Chemistry2002，79，： | 1 |
| 8 | Antioxidant activity of the cruciferous vegetable Maca(Lepidium meyenii)显示文摘 | SANDOVAL M OKUHAMA N N ANGELES F M | 2002 | Food Chemistry2002，79，2： | 1 |
| 9 | Antioxidant activity of the cruciferous vegetable Maca(Lepidium meyenii)显示文摘 | Sandoval M Okuhama N N Angeles F M | 2002 | Food Chemistry2002，79，2： | 1 |
| 10 | Lisinopril lowers cardiac adrenergic drive and increase beta-receptor density in the failing human heart显示文摘 | GILBERT E M SANDOVAL A LARRABEE P | 1993 | Circulation1993，88，： | 1 |
| 11 | Performance and tissue zinc and metallothionein accumulation in chicks fed a high dietary level of zinc 显示文摘 | Sandoval M Henry PR Luo XG et af | 1998 | Poult Sci1998，77，： | 1 |
| 12 | Epidemio!ogy and clinical characteristics of Ulcerative colitis in north - eastern Mexico 显示文摘 | Bosques-Padilla F J Sandoval - Garcia E R Martinez - Vazquez M A | 2011 | Rev Gastroenterol Mex2011，76，1： | 1 |
| 13 | Ultraviolet spectra of QSOs, BL Lacertae objects, and Seyfert galaxies显示文摘 | LANZETTA K M TURNSHEK D A SANDOVAL J | 1993 | ApJS1993，84，2： | 1 |
| 14 | Agave tequilana MADS genes show novel expression patterns in meristems, development bulbils and floral organs 显示文摘 | Sandoval S C D Ju6rez M J A Simpson J | 2012 | Sexual Plant Reproduction2012，25，1： | 1 |
| 15 | Bioplastics from Microorganisms 显示文摘 | LUENGO J M GARCIA B SANDOVAL A | 2003 | Curr Opin Microbiol2003，6，： | 1 |
| 16 | A note on comparisons among coherent systems with depen- dent components using Signature显示文摘 | NAVARRO J RUIZ J M SANDOVAL C J | 2005 | Statistics Prob- ability Letters2005，72，2： | 1 |
| 17 | Effects of cornoil on glass transition temperatures of cassava starch显示文摘 | L Madrigal A J Sandoval A J M il ller | 2011 | Carbohydrate Polymer2011，85，4： | 1 |
| 18 | Finite size effects in Fe nanowire soli&solid phase transitions: a molecular cly- namics approach 显示文摘 | SANDOVAL L URBASSEK H M | 2009 | Nano Letters2009，9，6： | 1 |
| 19 | Bioplastics from microorganisms 显示文摘 | Jose' M Luengo Bele' n Garcl'a Angel Sandoval | 2003 | Current Opinion in Microbiology2003，6，： | 1 |
| 20 | Protective effect of quercetin on experimental chronic cadmiumnephrotoxicity in rats is based on its antioxidant properties 显示文摘 | MORALES A I VICENTE-SANCHEZ C SANDOVAL J M etal | 2006 | Foodand Chemical Toxicology2006，44，12： | 1 |
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