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| 1 | High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound显示文摘AIM To examine whether high-flow nasal oxygen(HFNO) availability influences the use of general anesthesia(GA) in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) and endoscopic ultrasound(EUS) and associated outcomes.METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for deep sedation at the time of their endoscopy. During the first and last 3-mo eras(era 1 and 3), no HFNO was available, whereas it was an option during the second 3-mo era(era 2). The primary outcome was the percent utilization of GA vs deep sedation in each period. Secondary outcomes included oxygen saturation nadir during sedation between periods, as well as procedure duration, and anesthesia-only time between periods and for GA vs sedation cases respectively.RESULTS During the study period 238 ERCP or EUS cases were identified for analysis. Statistical testing was employed and a P < 0.050 was significant unless the Bonferroni correction for multiple comparisons was used. General anesthesia use was significantly lower in era 2 compared to era 1 with the same trend between era 2 and 3(P = 0.012 and 0.045 respectively). The oxygen saturation nadir during sedation was significantly higher in era 2 compared to era 3(P < 0.001) but not between eras 1 and 2(P = 0.028) or 1 and 3(P = 0.069). The procedure time within each era was significantly longer under GA compared to deep sedation(P ≤ 0.007) as was the anesthesia-only time(P ≤ 0.001).CONCLUSION High-flow nasal oxygen availability was associated with decreased GA utilization and improved oxygenation for ERCP and EUS during sedation. | Roman Schumann Nikola S Natov Klifford A Rocuts-Martinez Matthew D Finkelman Tom V Phan Sanjay R Hegde Robert M Knapp | 2016 | World Journal of Gastroenterology2016，22，47： | 9 |
| 2 | Hepatoprotective activity of Hepax-A polyherbal formulation显示文摘Objective:To evaluate the hepatoprotective potential of Hepax,a polyherbal formulation,against three experimentally induced hepatotoxicity models in rats.Methods:Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models,namely, carbon tetrachloride(CCl_4),paracetamol and thiocetamide induced hepatotoxicity in rats. Results:Administration of hepatotoxins(CCl_4,paracetamol and thiocetamide) showed significant morphological,biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters(liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters(SGPT,SCOT,ALP and total bilirubin),which were evidently showed in histopathological study.Conclusions:The Hepax has highly significant hepatoprotective effect at 100 and 200 mg/kg,p.o.on the liver of all the three experimental animal models. | VC Devaraj B Gopala Krishna GL Viswanatha Jagadish V Kamath Sanjay Kumar | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 4 |
| 3 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 4 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 5 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 2 |
| 6 | Novel vinyl ester resin and its urethane derivatives for glass reinforced composites 显示文摘 | Sanjay V P Dipak K R Jatin R T | 1999 | Die Angewandte Makromolekulare Chemie1999，265，1： | 1 |
| 7 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 8 | Synthesis and Anti-bacterial Activity of Some Novel 2-(6-Fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1H-benzimidazoles显示文摘 | BOBBA V S K SANJAY D V RAMANATHAM V K | 2006 | EurMedChem2006，41，： | 1 |
| 9 | Laparoscopic inguinal hernia repair in the pediatric age group-experience with 437 children显示文摘 | Sandesh V Parelkar Sanjay Oak Rahul Gupta | 2010 | Journal of Pediatric Surgery2010，45，： | 1 |
| 10 | A passive solar system for thermal comfort conditioning of building in composite climates 显示文摘 | Raman P Sanjay Mande Kishore V V N | 2000 | Solar Energy2000，70，4： | 1 |
| 11 | YoLk sac tumor of the ear: uncommon presentation of a rare tumor 显示文摘 | Kaveti V Sanjay R Ganeshula S | 2010 | J Clin Oncol2010，28，21： | 1 |
| 12 | A probabilistic approach to predict surface roughness in ceramic grinding显示文摘 | Sanjay A Rao P V | 2005 | International Journal of Machine Tools & Manufacture2005，45，： | 1 |
| 13 | Temperature distribution and residual stresses due to multipass welding in type 304 stainless steel and low carbon steel weld pads显示文摘 | MURUGAN S SANJAI K P KUMAR P V | 2001 | International Journal of Pressure Vessels and Piping2001，78，： | 1 |
| 14 | Predictive modeling of force and power based on a new analytical undeformed chip thickness model in ceramic grinding显示文摘 | Sanjay A Rao P V | 2013 | International Journal of Machine Tools & Manufacture2013，65，： | 1 |
| 15 | Functionalizafion of carbon nanotubes with amines and enzymes显示文摘 | Wang Y B Zafar I Sanjay V M | 2005 | Chemical Physics Letters2005，402，： | 1 |
| 16 | Metallophthalocyanine coated porous silicon gas sensor selective to NO 2显示文摘 | Gokarna Anisha | 2003 | Sensors and Actuators B2003，92，： | 1 |
| 17 | Traumatic diaphragmatic her- nia:Management by video assisted thoracoscopic repair显示文摘 | Sandesh V Parelkar Sanjay N | 2012 | J Indi- an Assoc Pediatr Surg2012，17，4： | 1 |
| 18 | Synthesis and anti-bacterial activity of some novel 2-(6-fluorochroman-2-yl)-1-alkyl/acyl/aroyl-1 H -benzimidazoles显示文摘 | BOBBA V S K SANJAY D V RAMANATHAM V K | 2006 | Eur Med Chem2006，41，： | 1 |
| 19 | Color spaces for transform-based image retrieval 显示文摘 | SANJAY N T SATISHKUMAR L V | 2010 | International Journal of Computer Applications2010，9，12： | 1 |
| 20 | Factors predicting advanced hepatic fibrosis in patients with postcholecystectomy bile duct strictures显示文摘 | Sanjay Singh Negi Sakhuja P Malhotra V | 2004 | Arch Surg2004，139，： | 1 |
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