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| 1 | High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound显示文摘AIM To examine whether high-flow nasal oxygen(HFNO) availability influences the use of general anesthesia(GA) in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) and endoscopic ultrasound(EUS) and associated outcomes.METHODS In this retrospective study, patients were stratified into 3 eras between October 1, 2013 and June 30, 2014 based on HFNO availability for deep sedation at the time of their endoscopy. During the first and last 3-mo eras(era 1 and 3), no HFNO was available, whereas it was an option during the second 3-mo era(era 2). The primary outcome was the percent utilization of GA vs deep sedation in each period. Secondary outcomes included oxygen saturation nadir during sedation between periods, as well as procedure duration, and anesthesia-only time between periods and for GA vs sedation cases respectively.RESULTS During the study period 238 ERCP or EUS cases were identified for analysis. Statistical testing was employed and a P < 0.050 was significant unless the Bonferroni correction for multiple comparisons was used. General anesthesia use was significantly lower in era 2 compared to era 1 with the same trend between era 2 and 3(P = 0.012 and 0.045 respectively). The oxygen saturation nadir during sedation was significantly higher in era 2 compared to era 3(P < 0.001) but not between eras 1 and 2(P = 0.028) or 1 and 3(P = 0.069). The procedure time within each era was significantly longer under GA compared to deep sedation(P ≤ 0.007) as was the anesthesia-only time(P ≤ 0.001).CONCLUSION High-flow nasal oxygen availability was associated with decreased GA utilization and improved oxygenation for ERCP and EUS during sedation. | Roman Schumann Nikola S Natov Klifford A Rocuts-Martinez Matthew D Finkelman Tom V Phan Sanjay R Hegde Robert M Knapp | 2016 | World Journal of Gastroenterology2016，22，47： | 9 |
| 2 | Patients undergoing infrainguinal bypass to treat atherosclerotic vascular disease are underprescribed cardioprotective medications: effect on graft patency, limb salvage, and mortality显示文摘 | Peter K Henke Susan Blackburn Mary C Proctor Jeri Stevens Debabrata Mukherjee Sanjay Rajagopalin Gilbert R Upchurch James C Stanley Kim A Eagle | 2004 | Journal of Vascular Surgery2004，，： | 2 |
| 3 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 4 | 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial显示文摘 | Baptist Gallwitz Julio Rosenstock Thomas Rauch Sudipta Bhattacharya Sanjay Patel Maximilian von Eynatten Klaus A Dugi Hans-Juergen Woerle | 2012 | The Lancet2012，，9840： | 2 |
| 5 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 2 |
| 6 | Src kinase activity is essential for osteoclast function 显示文摘 | Miyazaki T Sanjay A Neff L | 2004 | J Bid Chem2004，279，17： | 1 |
| 7 | Erlotinib, docetaxel, and gefitinib in sequential cohorts with relapsed non-small cell lung cancer显示文摘 | Sanjay P Yolanda B Sue A | 2008 | Lung Cancer2008，59，： | 1 |
| 8 | Facile baylis-hillman reaction of substituted 3-isoxazolecarbaldehydes:the impact of a proximal heteroatom within a heterocycle on the acceleration of the reaction显示文摘 | ROY A K SANJAY B | 2003 | Synthesis2003，15，： | 1 |
| 9 | Green tea polyphenol epigallocateehin-3-galhte differentially modulates nuclear factor kB in cancer cells versus normal cells显示文摘 | Sanjay G Hasan M | 2000 | Arch Biochem Biophys2000，376，： | 1 |
| 10 | Ionic liquid-promoted regiospecific Friedlander annulation:novel synthesis of quinolines and fused polycyclic quinolines显示文摘 | Sanjay S Palimkar Shapi A Siddiqui Thomas Daniel | 2003 | J Org Chem2003，68，24： | 1 |
| 11 | A New Iterative Method for Solving Absolute Value Equations显示文摘 | MUHAMMAD A N JAVED I SANJAY K | 2011 | International Journal of the Physical Sciences2011，6，7： | 1 |
| 12 | Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity显示文摘 | Anthony N Kalloo Vikesh K Singh Sanjay B Jagannath Hideaki Niiyama Susan L Hill Cheryl A Vaughn Carolyn A Magee Sergey V Kantsevoy | 2004 | Gastrointestinal Endoscopy2004，，1： | 1 |
| 13 | Use of natural coagulants of plant origin in production of soycurd (Tofu)显示文摘 | SANJAY K SUBRAMANIAN R SENTHIL A | 2008 | International Journal of Food Engineering2008，4，1： | 1 |
| 14 | Src kinase activity is essential for osteoclast function显示文摘 | MIYAZAKI T SANJAY A NEFF L | 2004 | J Biol Chem2004，279，17： | 1 |
| 15 | Src'kinase activity is essential for osteoclast function显示文摘 | Miyazaki T Sanjay A Neff L | 2004 | J Biol Chem2004，279，17： | 1 |
| 16 | Choices in Pain Management Following Thoracotomy显示文摘 | Christinc P A Sanjay G | 1999 | Chest1999，115，： | 1 |
| 17 | A probabilistic approach to predict surface roughness in ceramic grinding显示文摘 | Sanjay A Rao P V | 2005 | International Journal of Machine Tools & Manufacture2005，45，： | 1 |
| 18 | Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia显示文摘 | Nakajima A Sanjay A Chiusaroli R | 2009 | J Bone Miner Res2009，24，7： | 1 |
| 19 | Rare and fatal comp-lication of gianturco tracheobronchial stent显示文摘 | Sanjay A Narain M Rasheed A | 2007 | Ann Thorae Surg2007，84，： | 1 |
| 20 | Effect of wet milling process on the solid state of indomethacin and simvastatin 显示文摘 | Sharma Puneet Denny William A Garg Sanjay | 2009 | International Journal of Pharmaeeutics2009，380，12： | 1 |
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