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您的检索式：作者名="Sara Zahid"
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| 1 | Assessment of Biochemical and Antioxidative Status in Patients Suffering from Dengue Fever显示文摘A multi-centred study was designed to collect dengue epidemiologic data from government and registered private hospitals/clinics and maintained archive of frozen specimens in bio-bank to be used for future dengue epidemic control program, and assess the epidemiology of dengue fever(DF) by evaluating biochemical and oxidative status of patients. ELISA Ig M antibodies test was done to confirm DF. From August 2010 to December 2011, 101 confirmed blood samples of DF patients referred to pathology lab of Jinnah Hospital Lahore were subjected to the epidemiologic assessment by evaluating the biochemical and physiological indices and alterations of circulating antioxidants. Clinical features of DF patients and effect of fever on blood components and serum proteins of liver were recorded. The hospital stay in DF, dengue hemorrhagic fever(DHF) and dengue shock syndrome(DSS) showed significant difference. Significant increases in serum alanine amino transferase(ALT)(P=0.000), aspartate amino transferase(AST)(P=0.000), alkaline phosphatase(ALP)(P=0.000), malondialdehyde(MDA) along with significant decreases in total protein(TP)(P=0.000), reduced glutathione(GSH)(P=0.000), superoxide dismutase(SOD), catalase(CAT)(P=0.000), and sialic acid contents(P=0.016) were observed. A positive correlation existed between bound sialic acid levels, liver enzymes and circulating antioxidants(r=0.656, P=0.016). In the present study, alterations of circulating antioxidants in DF suggest that DF might be a metabolic response to an acute, self-limiting tropical viral infection, and a consequence of the viral inflammatory process. | Mahmood Rasool Arif Malik Khalid Mahmud Khan Muhammad Saeed Qureshi Beenish Shabbir Sara Zahid Muhammad Asif Abdul Manan Sana Rashid Saima Rubab Khan Hafiz Muhammad Arsalan Rabail Alam Mahwish Arooj Mahmood Husain Qazi Adeel Gulzar Ahmed Chaudhary Adel Mohammed Abuzenadah Mohammed Hussain Al-Qahtani Sajjad Karim | 2015 | Journal of Huazhong University of Science and Technology(Medical Sciences)2015，35，3： | 0 |
| 2 | Transmitted cardiovascular pulsations on high resolution esophageal impedance manometry, and their significance in dysphagia显示文摘AIM To investigate the behavior of pulsatile pressure zones(PPZ's) as noted on high resolution esophageal impedance manometry(HREIM), and determine their association with dysphagia.METHODS Retrospective, single center case control design scr-eening HREIM studies for cases(dysphagia) and controls(no dysphagia). Thoracic radiology studies were reviewed further in cases for(thoracic cardiovascular) thoracic cardiovascular(TCV) structures in esophageal proximity to compare with HREIM findings. Manometric data was collected for number, location, axial length, PPZ pressure and esophageal clearance function(impedance). RESULTS Among 317 screened patients, 56% cases and 64% controls had PPZ's. Fifty cases had an available thoracic radiology comparison. The distribution of PPZ's in these 50 cases and 59 controls was similar(average 1.4 PPZ/patient). Controls(mean 31.2 ± SD 12 years) were a significantly younger population than cases(mean 67.3 ± SD 14.9 years) with P < 0.0001. The upright posture PPZ pressure was higher in controls(15.7 ± 10.0 mm Hg) than cases(10.8 ± 9.7 mm Hg). Although statistically significant(P = 0.005), it was a weak predictor using logistic regression and ROC model(AUC = 0.65). Three dysphagia patients had partial compression from external TCV on radiology(1 aberrant subclavian artery, 2 dilated left atrium). The posture(supine vs upright) with more prominent PPZ's impaired bolus clearance in 9 additional cases by > 20%. CONCLUSION Transmitted TCV pulsations observed in HREIM bear no significant impact on swallowing. However, in older adults with dysphagia, evidence of impaired bolus clearance on impedance should be evaluated for external TCV compression. These associations have never been explored previously in literature, and are novel. | Naueen A Chaudhry Kamran Zahid Sara Keihanian Yunfeng Dai Qing Zhang | 2017 | World Journal of Gastroenterology2017，23，44： | 0 |
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